北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 核医学科  > 期刊论文
学科主题: 临床医学
题名:
A comparative study of samarium-153-ethylenediaminetetramethylene phosphonic acid with pamidronate disodium in the treatment of patients with painful metastatic bone cancer
作者: Wang, RF; Zhang, CL; Zhu, SL; Zhu, M
关键词: samarium-1 53-ethylenediaminetetramethylene ; phosphonic acid (Sm-153-EDTMP) ; pamidronate disodium ; bone metastases
刊名: MEDICAL PRINCIPLES AND PRACTICE
发表日期: 2003-04-01
DOI: 10.1159/000069120
卷: 12, 期:2, 页:97-101
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: THERAPY ; TRIAL ; PALLIATION ; PROSTATE ; EFFICACY
英文摘要:

Objective: To assess the therapeutic efficacy and toxicity of samarium-153-ethylenediaminetetramethylene phosphonic acid Sm-(153-EDTMP) and pamidronate disodium in patients with painful metastatic bone cancer. Subjects and Methods: Eighteen patients with histopathologically confirmed malignancy and multifocal bone metastases were randomized into two equal groups of 9 patients each. Group A was treated with Sm-153-EDTMP, while group B was treated with pamidronate disodium. The pain score for each patient was recorded before and after therapy using visual analogue scales that graded both the intensity and frequency of the bone pain. Therapeutic response was classified as inefficient, mild, effective and excellent. Results: Pain score in each group prior to therapy was more than 6. In group A, 2 (22.2%) and 7 (77.8%) cases showed mild and effective response, respectively. The therapeutic efficacy of Sm-153-EDTMP was adjudged to be 77.8%. Transient myelosuppression was generally mild and reversible with white blood cells and platelets recovering after 6 weeks. In group B, palliative response in 4 cases (44.4%) was inefficient, in 1 case (11.1%) mild, in 3 cases (33.3%) effective and in 1 case (11.1%) excellent, with a therapeutic efficacy of 44.4% for pamidronate disodium. No hematological toxicity was noted. Conclusion: The data showed that the therapeutic efficacy of Sm-153-EDTPM was higher than that of pamidronate disodium (for pain relief maintained more than 3 weeks) and its incidence of blood toxicity was also higher than that of pamidronate disodium. Copyright (C) 2003 S. Karger AG, Basel.

语种: 英语
WOS记录号: WOS:000181911000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50232
Appears in Collections:北京大学第一临床医学院_核医学科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100034, Peoples R China

Recommended Citation:
Wang, RF,Zhang, CL,Zhu, SL,et al. A comparative study of samarium-153-ethylenediaminetetramethylene phosphonic acid with pamidronate disodium in the treatment of patients with painful metastatic bone cancer[J]. MEDICAL PRINCIPLES AND PRACTICE,2003,12(2):97-101.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, RF]'s Articles
[Zhang, CL]'s Articles
[Zhu, SL]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, RF]‘s Articles
[Zhang, CL]‘s Articles
[Zhu, SL]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace