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学科主题临床医学
Lymph node ratio as an independent prognostic indicator in stage III colorectal cancer: especially for fewer than 12 lymph nodes examined
Jiang, Kewei; Zhu, Yi; Liu, Yan; Ye, Yingjiang; Xie, Qiwei; Yang, Xiaodong; Wang, Shan
关键词Colorectal Cancer Lymph Node Ratio Prognosis
刊名TUMOR BIOLOGY
2014-11-01
DOI10.1007/s13277-014-2484-x
35期:11页:11685-11690
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]COLON-CANCER ; CURATIVE RESECTION ; GASTRIC-CARCINOMA ; SURVIVAL ; NUMBER ; ADENOCARCINOMA ; STATISTICS
英文摘要

Although nodal invasion represents one of the most powerful prognostic indicators in colorectal cancer (CRC), marked heterogeneity exists within stage III patients. Lymph node ratio (LNR) may offer more precise prognostication in stage III CRC. The aim of this study is to investigate the prognostic impact of LNR on survival in stage III CRC patients. We retrospectively reviewed the data of 288 consecutive patients who underwent radical resection for stage III CRC between January 2000 and December 2008 in the Gastrointestinal Surgery Department, Peking University People′s Hospital. The patients were divided into three groups according to LNR quartiles: LNR < 0.167 (n = 72), 0.167 a parts per thousand currency signaEuro parts per thousand LNR < 0.562 (n = 140), and LNR a parts per thousand yenaEuro parts per thousand 0.562 (n = 76). The association between overall survival (OS) and disease-free survival (DFS) and 11 variables including age, gender, tumor location, size, grade, histology, tumor (T) stage, number of metastatic LNs, and LNR was analyzed by multivariate analysis. Survival curves were plotted by the Kaplan-Meier method. Both LNR and the number of metastatic LNs were significant prognostic factors for 5-year DFS and OS in stage III CRC patients. LNR was an independent prognostic factor for 5-year OS. LNR remained an independent prognostic factor in patients with fewer than 12 lymph nodes examined. LNR was a potent independent prognostic predictor for OS and DFS in stage III CRC patients, especially for patients with fewer than 12 lymph nodes examined.

语种英语
WOS记录号WOS:000345413100128
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50234
专题北京大学第二临床医学院_胃肠外科
北京大学基础医学院
北京大学第三临床医学院_血液内科
作者单位Peking Univ, Peoples Hosp, Dept Gastrointestinal Surg, Beijing 100044, Peoples R China
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GB/T 7714
Jiang, Kewei,Zhu, Yi,Liu, Yan,et al. Lymph node ratio as an independent prognostic indicator in stage III colorectal cancer: especially for fewer than 12 lymph nodes examined[J]. TUMOR BIOLOGY,2014,35(11):11685-11690.
APA Jiang, Kewei.,Zhu, Yi.,Liu, Yan.,Ye, Yingjiang.,Xie, Qiwei.,...&Wang, Shan.(2014).Lymph node ratio as an independent prognostic indicator in stage III colorectal cancer: especially for fewer than 12 lymph nodes examined.TUMOR BIOLOGY,35(11),11685-11690.
MLA Jiang, Kewei,et al."Lymph node ratio as an independent prognostic indicator in stage III colorectal cancer: especially for fewer than 12 lymph nodes examined".TUMOR BIOLOGY 35.11(2014):11685-11690.
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