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学科主题: 临床医学
题名:
Lymph node ratio as an independent prognostic indicator in stage III colorectal cancer: especially for fewer than 12 lymph nodes examined
作者: Jiang, Kewei; Zhu, Yi; Liu, Yan; Ye, Yingjiang; Xie, Qiwei; Yang, Xiaodong; Wang, Shan
关键词: Colorectal cancer ; Lymph node ratio ; Prognosis
刊名: TUMOR BIOLOGY
发表日期: 2014-11-01
DOI: 10.1007/s13277-014-2484-x
卷: 35, 期:11, 页:11685-11690
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: COLON-CANCER ; CURATIVE RESECTION ; GASTRIC-CARCINOMA ; SURVIVAL ; NUMBER ; ADENOCARCINOMA ; STATISTICS
英文摘要:

Although nodal invasion represents one of the most powerful prognostic indicators in colorectal cancer (CRC), marked heterogeneity exists within stage III patients. Lymph node ratio (LNR) may offer more precise prognostication in stage III CRC. The aim of this study is to investigate the prognostic impact of LNR on survival in stage III CRC patients. We retrospectively reviewed the data of 288 consecutive patients who underwent radical resection for stage III CRC between January 2000 and December 2008 in the Gastrointestinal Surgery Department, Peking University People′s Hospital. The patients were divided into three groups according to LNR quartiles: LNR < 0.167 (n = 72), 0.167 a parts per thousand currency signaEuro parts per thousand LNR < 0.562 (n = 140), and LNR a parts per thousand yenaEuro parts per thousand 0.562 (n = 76). The association between overall survival (OS) and disease-free survival (DFS) and 11 variables including age, gender, tumor location, size, grade, histology, tumor (T) stage, number of metastatic LNs, and LNR was analyzed by multivariate analysis. Survival curves were plotted by the Kaplan-Meier method. Both LNR and the number of metastatic LNs were significant prognostic factors for 5-year DFS and OS in stage III CRC patients. LNR was an independent prognostic factor for 5-year OS. LNR remained an independent prognostic factor in patients with fewer than 12 lymph nodes examined. LNR was a potent independent prognostic predictor for OS and DFS in stage III CRC patients, especially for patients with fewer than 12 lymph nodes examined.

语种: 英语
WOS记录号: WOS:000345413100128
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50234
Appears in Collections:北京大学第二临床医学院_胃肠外科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Gastrointestinal Surg, Beijing 100044, Peoples R China

Recommended Citation:
Jiang, Kewei,Zhu, Yi,Liu, Yan,et al. Lymph node ratio as an independent prognostic indicator in stage III colorectal cancer: especially for fewer than 12 lymph nodes examined[J]. TUMOR BIOLOGY,2014,35(11):11685-11690.
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