IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Association of INSIG2 rs9308762 With ALT Level Independent of BMI
Guan, Li1; Shang, Xiao-Rui1; Liu, Fang-Hong1; Song, Jie-Yun2; Ma, Jun1; Wang, Hai-Jun1
关键词Insig2 Fto Mc4r Gene Nonalcoholic Fatty Liver Disease
刊名JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
2014-02-01
DOI10.1097/MPG.0b013e3182a87b71
58期:2页:155-159
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Nutrition & Dietetics ; Pediatrics
研究领域[WOS]Gastroenterology & Hepatology ; Nutrition & Dietetics ; Pediatrics
关键词[WOS]FATTY LIVER-DISEASE ; ASIA-PACIFIC REGION ; INSULIN-RESISTANCE ; RISK-FACTORS ; FTO GENE ; OBESITY ; COMMON ; MC4R ; PREVALENCE ; CHILDHOOD
英文摘要

Objectives:

An increasing number of people are at risk for developing nonalcoholic fatty liver disease (NAFLD). Because obesity is a risk factor for NAFLD, the common variants of obesity-susceptible genes may be associated with NAFLD. Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD.

Methods:

The case-control study recruited 1027 Chinese children ages 7 to 18 years, including 162 children with NAFLD and 865 children without NAFLD. Anthropometric measurements, alanine transaminase (ALT) detection, liver ultrasound examination, and genotyping of 8 gene variants were performed.

Results:

The A-allele of FTO rs9939609 was associated with increased NAFLD risk (P = 0.029, odds ratio 1.43), but was not significant after being adjusted for body mass index (BMI) (P = 0.268). We also found an association between the 2 variants (rs12970134 in MC4R and rs9308762 in INSIG2) and ALT level. For rs12970134, each additional A-allele increased ALT level by 1.87 IU/L (P = 0.032). For rs9308762, the homozygotes of the C-allele had a higher ALT level than the T-allele carriers (beta = 3.19, P = 0.007). After adjustment for BMI, the former association did not exist, whereas the latter reminded significant (P = 0.003).

Conclusions:

The FTO rs9939609 A-allele increased risk of NAFLD and MC4R rs12970134 was associated with ALT level through an effect on BMI. The association between INSIG2 rs9308762 and ALT level was independent of BMI. The results provided evidence for identifying genetic factors of NAFLD and may be useful for risk assessment and personalized medicine of NAFLD.

语种英语
WOS记录号WOS:000335379300014
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50241
专题北京大学公共卫生学院
北京大学公共卫生学院_公共卫生学院
北京大学医学图书馆_流通阅览部
北京大学临床肿瘤学院_供应室
作者单位1.Peking Univ, Inst Child & Adolescent Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Div Maternal & Child Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Guan, Li,Shang, Xiao-Rui,Liu, Fang-Hong,et al. Association of INSIG2 rs9308762 With ALT Level Independent of BMI[J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION,2014,58(2):155-159.
APA Guan, Li,Shang, Xiao-Rui,Liu, Fang-Hong,Song, Jie-Yun,Ma, Jun,&Wang, Hai-Jun.(2014).Association of INSIG2 rs9308762 With ALT Level Independent of BMI.JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION,58(2),155-159.
MLA Guan, Li,et al."Association of INSIG2 rs9308762 With ALT Level Independent of BMI".JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 58.2(2014):155-159.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Guan, Li]的文章
[Shang, Xiao-Rui]的文章
[Liu, Fang-Hong]的文章
百度学术
百度学术中相似的文章
[Guan, Li]的文章
[Shang, Xiao-Rui]的文章
[Liu, Fang-Hong]的文章
必应学术
必应学术中相似的文章
[Guan, Li]的文章
[Shang, Xiao-Rui]的文章
[Liu, Fang-Hong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。