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学科主题: 公共卫生
题名:
Association of INSIG2 rs9308762 With ALT Level Independent of BMI
作者: Guan, Li1; Shang, Xiao-Rui1; Liu, Fang-Hong1; Song, Jie-Yun2; Ma, Jun1; Wang, Hai-Jun1
关键词: INSIG2 ; FTO ; MC4R ; gene ; nonalcoholic fatty liver disease
刊名: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
发表日期: 2014-02-01
DOI: 10.1097/MPG.0b013e3182a87b71
卷: 58, 期:2, 页:155-159
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Nutrition & Dietetics ; Pediatrics
研究领域[WOS]: Gastroenterology & Hepatology ; Nutrition & Dietetics ; Pediatrics
关键词[WOS]: FATTY LIVER-DISEASE ; ASIA-PACIFIC REGION ; INSULIN-RESISTANCE ; RISK-FACTORS ; FTO GENE ; OBESITY ; COMMON ; MC4R ; PREVALENCE ; CHILDHOOD
英文摘要:

Objectives:

An increasing number of people are at risk for developing nonalcoholic fatty liver disease (NAFLD). Because obesity is a risk factor for NAFLD, the common variants of obesity-susceptible genes may be associated with NAFLD. Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD.

Methods:

The case-control study recruited 1027 Chinese children ages 7 to 18 years, including 162 children with NAFLD and 865 children without NAFLD. Anthropometric measurements, alanine transaminase (ALT) detection, liver ultrasound examination, and genotyping of 8 gene variants were performed.

Results:

The A-allele of FTO rs9939609 was associated with increased NAFLD risk (P = 0.029, odds ratio 1.43), but was not significant after being adjusted for body mass index (BMI) (P = 0.268). We also found an association between the 2 variants (rs12970134 in MC4R and rs9308762 in INSIG2) and ALT level. For rs12970134, each additional A-allele increased ALT level by 1.87 IU/L (P = 0.032). For rs9308762, the homozygotes of the C-allele had a higher ALT level than the T-allele carriers (beta = 3.19, P = 0.007). After adjustment for BMI, the former association did not exist, whereas the latter reminded significant (P = 0.003).

Conclusions:

The FTO rs9939609 A-allele increased risk of NAFLD and MC4R rs12970134 was associated with ALT level through an effect on BMI. The association between INSIG2 rs9308762 and ALT level was independent of BMI. The results provided evidence for identifying genetic factors of NAFLD and may be useful for risk assessment and personalized medicine of NAFLD.

语种: 英语
所属项目编号: 81172683 ; 2012CB517500
项目资助者: National Natural Science Foundation of China ; Major State Basic Research and Development Program of China (973 program)
WOS记录号: WOS:000335379300014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50241
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Inst Child & Adolescent Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Div Maternal & Child Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Guan, Li,Shang, Xiao-Rui,Liu, Fang-Hong,et al. Association of INSIG2 rs9308762 With ALT Level Independent of BMI[J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION,2014,58(2):155-159.
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