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Simultaneous quantification of six major active saponins of Panax notoginseng by high-performance liquid chromatography-UV method
Li, L1; Zhang, JL1; Sheng, YX1; Guo, DA1; Wang, Q1; Guo, HZ1
关键词High-performance Liquid Chromatography Panax Notoginseng Ginsenosides Notoginsenoside
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2005-06-01
DOI10.1016/j.jpba.2004.12.002
38期:1页:45-51
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]DAMMARANE-SAPONINS ; TRITERPENE OLIGOGLYCOSIDES ; BIOACTIVE SAPONINS ; BURK CHEN,F.H ; DRIED ROOT ; GINSENG ; GLYCOSIDES
英文摘要

A simple, sensitive and specific high-performance liquid chromatography-UV (HPLC-UV) method has been developed for the first time to simultaneously quantify the six major active saponins of Panax notoginseng, namely notoginsenoside R-1, ginsenoside Rg(1), Rb-1, Rg(2), Rh-1 and Rd. Astragaloside IV is used as the internal standard. This HPLC assay was performed on a reversed-phase C-18 column with gradient elution of acetonitrile and 0.01% formic acid in 30 min. The method provided good reproducibility and sensitivity for the quantification of six saponins with overall intra- and inter-day precision and accuracy of less than 4.0% and higher than 90%, respectively. This assay is successfully applied to the determination of the six saponins in 23 notoginseng samples. The results indicated that the developed HPLC assay can be readily utilized as a quality control method for P. notoginseng. (c) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000230017500008
引用统计
被引频次:96[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50249
专题北京大学药学院
北京大学第一临床医学院_医疗耗材科
北京大学精神卫生研究所_药房
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, Modern Res Ctr Tradit Chinese Med, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Li, L,Zhang, JL,Sheng, YX,et al. Simultaneous quantification of six major active saponins of Panax notoginseng by high-performance liquid chromatography-UV method[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2005,38(1):45-51.
APA Li, L,Zhang, JL,Sheng, YX,Guo, DA,Wang, Q,&Guo, HZ.(2005).Simultaneous quantification of six major active saponins of Panax notoginseng by high-performance liquid chromatography-UV method.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,38(1),45-51.
MLA Li, L,et al."Simultaneous quantification of six major active saponins of Panax notoginseng by high-performance liquid chromatography-UV method".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 38.1(2005):45-51.
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