学科主题临床医学
Effects of vitamin E on the proliferation and collagen synthesis of rat hepatic stellate cells treated with IL-2 or TNF-alpha
Zhan, YT1; Wang, Y1; Wei, L1; Chen, HS1
关键词Hepatic Stellate Cells Vitamin e Tumor Necrosis Factor-a . Interleukin-2
刊名CHINESE MEDICAL JOURNAL
2003-03-01
116期:3页:472-474
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]FAT-STORING CELLS ; CHRONIC LIVER-DISEASE ; GENE-EXPRESSION ; E-DEFICIENCY ; SUPPLEMENTATION ; CIRRHOSIS ; FIBROSIS ; ADULTS
英文摘要

Objective To study the effects of vitamin E on the proliferation and collagen synthesis of rat hepatic stellate cells treated with interleukin-2 (IL-2) or tumor necrosis factor-alpha (TNF-alpha). Methods Hepatic stellate cells were isolated from male Sprague-Dawley rats by using modified Friedman′ s method. Using the isolated cells cultured and treated with IL-2 or TNF-alpha, we studied the effects of vitamin E on their proliferation and collagen synthesis through an H-3-thymidine and H-3-proline incorporation assay, as well as through observation of these cells under a contrary phase microscope. Results Adding IL-2 increased the both proliferation and collagen synthesis of hepatic stellate cells. Their proliferation was also increased by the addition of TNF-alpha, although it decreased collagen synthesis. Vitamin E had marked inhibitory effects on the ability of cells treated with IL-2 or TNF-alpha to reproduce or synthesize collagen. Conclusion Vitamin E can inhibit the proliferation and collagen synthesis of hepatic stellate cells. It is possible that vitamin E affects liver fibrosis through these activities.

语种英语
WOS记录号WOS:000182180100035
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50251
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Capital Univ Med Sci, Beijing Tongren Hosp, Beijing 100730, Peoples R China
2.Beijing Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China
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GB/T 7714
Zhan, YT,Wang, Y,Wei, L,et al. Effects of vitamin E on the proliferation and collagen synthesis of rat hepatic stellate cells treated with IL-2 or TNF-alpha[J]. CHINESE MEDICAL JOURNAL,2003,116(3):472-474.
APA Zhan, YT,Wang, Y,Wei, L,&Chen, HS.(2003).Effects of vitamin E on the proliferation and collagen synthesis of rat hepatic stellate cells treated with IL-2 or TNF-alpha.CHINESE MEDICAL JOURNAL,116(3),472-474.
MLA Zhan, YT,et al."Effects of vitamin E on the proliferation and collagen synthesis of rat hepatic stellate cells treated with IL-2 or TNF-alpha".CHINESE MEDICAL JOURNAL 116.3(2003):472-474.
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