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学科主题: 临床医学
题名:
Effects of vitamin E on the proliferation and collagen synthesis of rat hepatic stellate cells treated with IL-2 or TNF-alpha
作者: Zhan, YT1; Wang, Y1; Wei, L1; Chen, HS1
关键词: hepatic stellate cells ; vitamin E ; tumor necrosis factor-a . interleukin-2
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2003-03-01
卷: 116, 期:3, 页:472-474
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: FAT-STORING CELLS ; CHRONIC LIVER-DISEASE ; GENE-EXPRESSION ; E-DEFICIENCY ; SUPPLEMENTATION ; CIRRHOSIS ; FIBROSIS ; ADULTS
英文摘要:

Objective To study the effects of vitamin E on the proliferation and collagen synthesis of rat hepatic stellate cells treated with interleukin-2 (IL-2) or tumor necrosis factor-alpha (TNF-alpha). Methods Hepatic stellate cells were isolated from male Sprague-Dawley rats by using modified Friedman′ s method. Using the isolated cells cultured and treated with IL-2 or TNF-alpha, we studied the effects of vitamin E on their proliferation and collagen synthesis through an H-3-thymidine and H-3-proline incorporation assay, as well as through observation of these cells under a contrary phase microscope. Results Adding IL-2 increased the both proliferation and collagen synthesis of hepatic stellate cells. Their proliferation was also increased by the addition of TNF-alpha, although it decreased collagen synthesis. Vitamin E had marked inhibitory effects on the ability of cells treated with IL-2 or TNF-alpha to reproduce or synthesize collagen. Conclusion Vitamin E can inhibit the proliferation and collagen synthesis of hepatic stellate cells. It is possible that vitamin E affects liver fibrosis through these activities.

语种: 英语
WOS记录号: WOS:000182180100035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50251
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.Capital Univ Med Sci, Beijing Tongren Hosp, Beijing 100730, Peoples R China
2.Beijing Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Zhan, YT,Wang, Y,Wei, L,et al. Effects of vitamin E on the proliferation and collagen synthesis of rat hepatic stellate cells treated with IL-2 or TNF-alpha[J]. CHINESE MEDICAL JOURNAL,2003,116(3):472-474.
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