IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Mycoplasmal membrane protein p37 promotes malignant changes in mammalian cells
Liu, Wenbin1; Ren, Tingting1; Jiang, Beihai1; Gong, Manman1; Shou, Chengchao1
关键词Mycoplasma P37 Protein Antisenescence Clonogenicity Adhesion
刊名CANADIAN JOURNAL OF MICROBIOLOGY
2007-02-01
DOI10.1139/W06-120
53期:2页:270-276
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Immunology ; Microbiology
研究领域[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Immunology ; Microbiology
关键词[WOS]GROWTH ; CANCER ; INFECTIONS ; CARCINOMA ; ADHESION ; TUMOR ; TRANSFORMATION ; INVASIVENESS ; ONCOGENESIS ; METASTASIS
英文摘要

Evidence of Mycoplasma hyorhinis infection in human gastric cancer tissues has been found in previous work. In this study, we demonstrate that the expression of p37, a membrane lipoprotein of M. hyorhinis, in mammalian cells induces antisenescence, enhances clonogenicity in soft agar, and co-operates with human epidermal growth factor receptor-related 2 to inhibit cell adhesion. Conversely, truncated p37 protein, with the first 28 amino acids deleted from its N terminal, promotes cell senescence. Taken together, our findings suggest that p37 promotes malignant changes in mammalian cells. With the identification of this molecular component, which is responsible for mycoplasma malignancy-promoting activity, it is possible that a better understanding of the relationship between M. hyorhillis infection and human gastric cancers will lead to novel diagnostics and therapeutics.

语种英语
WOS记录号WOS:000246963200014
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50259
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_生化与分子生物学研究室
作者单位1.Peking Univ, Sch Oncol, Dept Biochem & Mol Biol, Beijing 100036, Peoples R China
2.Beijing Canc Hosp & Inst, Beijing 100036, Peoples R China
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Liu, Wenbin,Ren, Tingting,Jiang, Beihai,et al. Mycoplasmal membrane protein p37 promotes malignant changes in mammalian cells[J]. CANADIAN JOURNAL OF MICROBIOLOGY,2007,53(2):270-276.
APA Liu, Wenbin,Ren, Tingting,Jiang, Beihai,Gong, Manman,&Shou, Chengchao.(2007).Mycoplasmal membrane protein p37 promotes malignant changes in mammalian cells.CANADIAN JOURNAL OF MICROBIOLOGY,53(2),270-276.
MLA Liu, Wenbin,et al."Mycoplasmal membrane protein p37 promotes malignant changes in mammalian cells".CANADIAN JOURNAL OF MICROBIOLOGY 53.2(2007):270-276.
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