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学科主题: 临床医学
题名:
Mycoplasmal membrane protein p37 promotes malignant changes in mammalian cells
作者: Liu, Wenbin1; Ren, Tingting1; Jiang, Beihai1; Gong, Manman1; Shou, Chengchao1
关键词: mycoplasma ; p37 protein ; antisenescence ; clonogenicity ; adhesion
刊名: CANADIAN JOURNAL OF MICROBIOLOGY
发表日期: 2007-02-01
DOI: 10.1139/W06-120
卷: 53, 期:2, 页:270-276
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Immunology ; Microbiology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Immunology ; Microbiology
关键词[WOS]: GROWTH ; CANCER ; INFECTIONS ; CARCINOMA ; ADHESION ; TUMOR ; TRANSFORMATION ; INVASIVENESS ; ONCOGENESIS ; METASTASIS
英文摘要:

Evidence of Mycoplasma hyorhinis infection in human gastric cancer tissues has been found in previous work. In this study, we demonstrate that the expression of p37, a membrane lipoprotein of M. hyorhinis, in mammalian cells induces antisenescence, enhances clonogenicity in soft agar, and co-operates with human epidermal growth factor receptor-related 2 to inhibit cell adhesion. Conversely, truncated p37 protein, with the first 28 amino acids deleted from its N terminal, promotes cell senescence. Taken together, our findings suggest that p37 promotes malignant changes in mammalian cells. With the identification of this molecular component, which is responsible for mycoplasma malignancy-promoting activity, it is possible that a better understanding of the relationship between M. hyorhillis infection and human gastric cancers will lead to novel diagnostics and therapeutics.

语种: 英语
WOS记录号: WOS:000246963200014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50259
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Dept Biochem & Mol Biol, Beijing 100036, Peoples R China
2.Beijing Canc Hosp & Inst, Beijing 100036, Peoples R China

Recommended Citation:
Liu, Wenbin,Ren, Tingting,Jiang, Beihai,et al. Mycoplasmal membrane protein p37 promotes malignant changes in mammalian cells[J]. CANADIAN JOURNAL OF MICROBIOLOGY,2007,53(2):270-276.
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