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学科主题: 临床医学
题名:
Autoantibodies against monomeric C-reactive protein in sera from patients with lupus nephritis are associated with disease activity and renal tubulointerstitial lesions
作者: Tan, Ying1,2; Yu, Feng1,2; Yang, Haizhen3; Chen, Min1,2; Fang, Qiying1,2; Zhao, Ming-hui1,2
关键词: mCRP autoantibodies ; Activity index ; Chronicity index ; Lupus nephritis
刊名: HUMAN IMMUNOLOGY
发表日期: 2008-12-01
DOI: 10.1016/j.humimm.2008.09.006
卷: 69, 期:12, 页:840-844
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: AORTIC ENDOTHELIAL-CELLS ; ACUTE-PHASE PROTEINS ; PENTAMERIC SYMMETRY ; HUMAN-NEUTROPHILS ; IMMUNE-COMPLEXES ; AMYLOID-P ; ERYTHEMATOSUS ; EXPRESSION ; ANTIBODIES ; CRP
英文摘要:

Serum levels of C-reactive protein (CRP) often remain low despite high disease activity in systemic lupus erythematosus (SLE). Sera from 96 patients with renal biopsy-proven active lupus nephritis, 24 of 96 patients in remission, and 49 patients with SLE with negative urinalysis (nonrenal SLE) was collected. Immunoglobulin G autoantibodies against monomeric CRP (mCRP) were screened by enzyme-linked immunosorbent assay with purified human CRP. Associations with clinical features, pathological data, and laboratory findings were investigated. The prevalence of mCRP autoantibodies in active lupus nephritis (57196, 59.4%) was significantly higher than that in patients with SLE without clinical evidence of kidney involvement (20/49, 40.8%, p = 0,034). For the 13 patients with positive mCRP autoantibodies and sequential sera, their positive mCRP autoantibodies in active phase turned negative in remission (13/13, 100%). Patients with mCRP autoantibodies had significantly higher SLEDAI scores than patients without mCRP autoantibodies (18.3 +/- 5.2 vs 15.8 +/- 4.0, p = 0.013), who were more likely to experience acute renal failure(14/55 vs 2/33, p = 0.022), Oral Ulcer (15/57 vs 3/39, p = 0.022), and delayed activated partial thromboplastin time (18/52 vs 2/38, p 0.001). Positive correlations between levels of mCRP autoantibodies and semiquantitative scores of renal histologic features were first observed in lupus nephritis as follows: interstitial inflammation (r = 0.328), tubular atrophy(r = 0.276), interstitial fibrosis (r = 0.211), and chronicity index score (r = 0.243). Autoantibodies against mCRP are prevalent in patients with lupus nephritis and are associated with disease activity and renal tubulointerstitial lesions. (C) 2008 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.

语种: 英语
WOS记录号: WOS:000261925100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50271
Appears in Collections:北京大学第一临床医学院_大内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Med, Inst Nephrol,Renal Div, Beijing 100871, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100871, Peoples R China

Recommended Citation:
Tan, Ying,Yu, Feng,Yang, Haizhen,et al. Autoantibodies against monomeric C-reactive protein in sera from patients with lupus nephritis are associated with disease activity and renal tubulointerstitial lesions[J]. HUMAN IMMUNOLOGY,2008,69(12):840-844.
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