|Significance of AEG-1 Expression in Correlation With VEGF, Microvessel Density and Clinicopathological Characteristics in Triple-Negative Breast Cancer|
|Li, Cong1; Li, Rui2; Song, Hongtao1; Wang, Dong2; Feng, Tian5; Yu, Xiaoguang5; Zhao, Yulan1; Liu, Junjun1; Yu, Xiaoyu1; Wang, Yanbo4; Geng, Jingshu1,3|
|关键词||Triple-negative Breast Cancer Prognosis Angiogenesis Astrocyte-elevated Gene-1 Vascular Endothelial Growth Factor|
|刊名||JOURNAL OF SURGICAL ONCOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Oncology ; Surgery|
|研究领域[WOS]||Oncology ; Surgery|
|关键词[WOS]||ASTROCYTE ELEVATED GENE-1 ; ENDOTHELIAL GROWTH-FACTOR ; PROMOTES TUMOR ANGIOGENESIS ; PROTEIN EXPRESSION ; PROGRESSION ; METASTASIS ; ASSOCIATION ; ACTIVATION ; METADHERIN ; CARCINOMA|
Purpose: Our study is to examine astrocyte-elevated gene-1 (AEG-1) expression in triple-negative breast cancer and to determine whether it is associated with vascular endothelial growth factor (VEGF), microvessel density (MVD), clinicopathological parameters and poor survival.
Methods: Specimens from 125 patients with triple-negative breast cancers were investigated by immunohistochemistry for MVD, AEG-1 and VEGF expression. Correlations between the expression of AEG-1, VEGF, MVD, and various clinicopathological factors including survival status were studied.
Results: AEG-1 and VEGF were highly expressed in 56.8% and 52.8% of triple-negative breast cancer patients, respectively. The intensity of AEG-1 was gradually up-regulated from VEGF MVD low, VEGF high, or MVD high to VEGF MVD high tissues using Western blot analysis. Statistically significant correlation was found among AEG-1 and VEGF, and MVD. Moreover, AEG-1 expression was correlated with clinical stage, lymphatic venous invasion, lymph nodal metastasis, tumor size, Ki67, and recurrence. Patients with AEG-1 high-expression showed far lower disease-free survival (DFS) and overall survival (OS) rates than those with AEG-1 low-expression. For VEGF and MVD, there were similar results in these patients. Only AEG-1 expression and tumor size were independent prognostic factors for both DFS and OS by multivariate analysis. However, the prognostic impact of tumor size was not as strong as that of AEG-1.
Conclusions: AEG-1 expression may be related with tumor angiogenesis and progression and is a valuable prognostic factor in patients with triple-negative breast cancer. J. Surg. Oncol. 2011;103:184-192. (C) 2010 Wiley-Liss, Inc.
|项目编号||D2009-21 ; HCXB2010018 ; HCXS2010001|
|资助机构||Natural Science Foundation of Heilongjiang Province ; Harbin Medical University|
|作者单位||1.Harbin Med Coll, Affiliated Tumor Hosp, Dept Pathol, Harbin 150040, Peoples R China|
2.Peking Univ, Peoples Hosp, Dept Surg, Beijing 100044, Peoples R China
3.Harbin Med Coll, Dept Med Genet, Harbin 150086, Peoples R China
4.Harbin Med Coll, Affiliated Tumor Hosp, Dept Breast Surg, Harbin 150040, Peoples R China
5.Harbin Med Coll, Coll Basic Med Sci, Dept Biochem & Mol Biol, Harbin 150081, Peoples R China
|Li, Cong,Li, Rui,Song, Hongtao,et al. Significance of AEG-1 Expression in Correlation With VEGF, Microvessel Density and Clinicopathological Characteristics in Triple-Negative Breast Cancer[J]. JOURNAL OF SURGICAL ONCOLOGY,2011,103(2):184-192.|
|APA||Li, Cong.,Li, Rui.,Song, Hongtao.,Wang, Dong.,Feng, Tian.,...&Geng, Jingshu.(2011).Significance of AEG-1 Expression in Correlation With VEGF, Microvessel Density and Clinicopathological Characteristics in Triple-Negative Breast Cancer.JOURNAL OF SURGICAL ONCOLOGY,103(2),184-192.|
|MLA||Li, Cong,et al."Significance of AEG-1 Expression in Correlation With VEGF, Microvessel Density and Clinicopathological Characteristics in Triple-Negative Breast Cancer".JOURNAL OF SURGICAL ONCOLOGY 103.2(2011):184-192.|