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学科主题: 临床医学
题名:
Significance of AEG-1 Expression in Correlation With VEGF, Microvessel Density and Clinicopathological Characteristics in Triple-Negative Breast Cancer
作者: Li, Cong1; Li, Rui2; Song, Hongtao1; Wang, Dong2; Feng, Tian5; Yu, Xiaoguang5; Zhao, Yulan1; Liu, Junjun1; Yu, Xiaoyu1; Wang, Yanbo4; Geng, Jingshu1,3
关键词: triple-negative breast cancer ; prognosis ; angiogenesis ; astrocyte-elevated gene-1 ; vascular endothelial growth factor
刊名: JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2011-02-01
DOI: 10.1002/jso.21788
卷: 103, 期:2, 页:184-192
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: ASTROCYTE ELEVATED GENE-1 ; ENDOTHELIAL GROWTH-FACTOR ; PROMOTES TUMOR ANGIOGENESIS ; PROTEIN EXPRESSION ; PROGRESSION ; METASTASIS ; ASSOCIATION ; ACTIVATION ; METADHERIN ; CARCINOMA
英文摘要:

Purpose: Our study is to examine astrocyte-elevated gene-1 (AEG-1) expression in triple-negative breast cancer and to determine whether it is associated with vascular endothelial growth factor (VEGF), microvessel density (MVD), clinicopathological parameters and poor survival.

Methods: Specimens from 125 patients with triple-negative breast cancers were investigated by immunohistochemistry for MVD, AEG-1 and VEGF expression. Correlations between the expression of AEG-1, VEGF, MVD, and various clinicopathological factors including survival status were studied.

Results: AEG-1 and VEGF were highly expressed in 56.8% and 52.8% of triple-negative breast cancer patients, respectively. The intensity of AEG-1 was gradually up-regulated from VEGF MVD low, VEGF high, or MVD high to VEGF MVD high tissues using Western blot analysis. Statistically significant correlation was found among AEG-1 and VEGF, and MVD. Moreover, AEG-1 expression was correlated with clinical stage, lymphatic venous invasion, lymph nodal metastasis, tumor size, Ki67, and recurrence. Patients with AEG-1 high-expression showed far lower disease-free survival (DFS) and overall survival (OS) rates than those with AEG-1 low-expression. For VEGF and MVD, there were similar results in these patients. Only AEG-1 expression and tumor size were independent prognostic factors for both DFS and OS by multivariate analysis. However, the prognostic impact of tumor size was not as strong as that of AEG-1.

Conclusions: AEG-1 expression may be related with tumor angiogenesis and progression and is a valuable prognostic factor in patients with triple-negative breast cancer. J. Surg. Oncol. 2011;103:184-192. (C) 2010 Wiley-Liss, Inc.

语种: 英语
所属项目编号: D2009-21 ; HCXB2010018 ; HCXS2010001
项目资助者: Natural Science Foundation of Heilongjiang Province ; Harbin Medical University
WOS记录号: WOS:000287062000014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50272
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Harbin Med Coll, Affiliated Tumor Hosp, Dept Pathol, Harbin 150040, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Surg, Beijing 100044, Peoples R China
3.Harbin Med Coll, Dept Med Genet, Harbin 150086, Peoples R China
4.Harbin Med Coll, Affiliated Tumor Hosp, Dept Breast Surg, Harbin 150040, Peoples R China
5.Harbin Med Coll, Coll Basic Med Sci, Dept Biochem & Mol Biol, Harbin 150081, Peoples R China

Recommended Citation:
Li, Cong,Li, Rui,Song, Hongtao,et al. Significance of AEG-1 Expression in Correlation With VEGF, Microvessel Density and Clinicopathological Characteristics in Triple-Negative Breast Cancer[J]. JOURNAL OF SURGICAL ONCOLOGY,2011,103(2):184-192.
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