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学科主题: 口腔医学
题名:
Mean platelet volume as an inflammatory marker in patients with severe periodontitis
作者: Wang, Xian′ e(1); Meng, Huanxin; Xu, Li; Chen, Zhibin; Shi, Dong; Lv, Da
关键词: Periodontitits ; mean platelet volume ; inflammation markers
刊名: PLATELETS
发表日期: 2015
DOI: 10.3109/09537104.2013.875137
卷: 26, 期:1, 页:67-71
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Hematology
研究领域[WOS]: Cell Biology ; Hematology
关键词[WOS]: CORONARY-HEART-DISEASE ; CARDIOVASCULAR-DISEASE ; RHEUMATOID-ARTHRITIS ; LEUKOCYTE COUNT ; RISK ; ATHEROSCLEROSIS ; ASSOCIATION ; PROTEIN ; BLOOD ; LINK
英文摘要:

Periodontitis has become the leading cause of tooth loss in adults, and the host′s immunologic and inflammatory response to the bacteria can lead to periodontal destruction. In patients with periodontitis, platelets possess an increased activation status compared with platelets from healthy controls. Mean platelet volume (MPV) has been considered an important index of platelet activity and an inflammatory marker in many infectious diseases. The present study investigated the relationship between MPV and disease activity in subjects with severe periodontitis. Forty-five patients with periodontitis and 45 age and sex-matched healthy subjects were enrolled into the study. All subjects received periodontal and hematological examinations. The periodontitis patients were administered active periodontal treatment (APT). At baseline, a statistically significant decrease in MPV was noted in patients with periodontitis (9.73 +/- 1.06 fL) compared with healthy controls (10.24 +/- 1.07 fL). At 1 month post-APT, MPV was substantially increased (10.11 +/- 1.04 fL). Positive correlation was found between increase of MPV and decrease of periodontal probing depth after treatment(r = 0.377; p = 0.014). In conclusion, the decrease of MPV was related to the severe periodontal inflammation, and the value inversed shift after APT. MPV might reflect the disease activity of periodontitis.

语种: 英语
所属项目编号: 30471882 ; 30973319 ; 81271149 ; 81300879 ; 2002AA217091 ; 2007BAI18B02
项目资助者: National Natural Science Foundations of China Beijing, China ; National Key Project of Scientific and Technical Supporting Programs of China, Beijing, China ; Key program of Clinical Specialty, National Ministry of Health P.R.C., Beijing, China ; Capital Medical Development Research Foundation of Beijing, China
WOS记录号: WOS:000348147300013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50276
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: Peking Univ Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China

Recommended Citation:
Wang, Xian&prime,e,Meng, Huanxin,et al. Mean platelet volume as an inflammatory marker in patients with severe periodontitis[J]. PLATELETS,2015,26(1):67-71.
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