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学科主题口腔医学
Mean platelet volume as an inflammatory marker in patients with severe periodontitis
Wang, Xian′ e(1); Meng, Huanxin; Xu, Li; Chen, Zhibin; Shi, Dong; Lv, Da
关键词Periodontitits Mean Platelet Volume Inflammation Markers
刊名PLATELETS
2015
DOI10.3109/09537104.2013.875137
26期:1页:67-71
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Hematology
研究领域[WOS]Cell Biology ; Hematology
关键词[WOS]CORONARY-HEART-DISEASE ; CARDIOVASCULAR-DISEASE ; RHEUMATOID-ARTHRITIS ; LEUKOCYTE COUNT ; RISK ; ATHEROSCLEROSIS ; ASSOCIATION ; PROTEIN ; BLOOD ; LINK
英文摘要

Periodontitis has become the leading cause of tooth loss in adults, and the host′s immunologic and inflammatory response to the bacteria can lead to periodontal destruction. In patients with periodontitis, platelets possess an increased activation status compared with platelets from healthy controls. Mean platelet volume (MPV) has been considered an important index of platelet activity and an inflammatory marker in many infectious diseases. The present study investigated the relationship between MPV and disease activity in subjects with severe periodontitis. Forty-five patients with periodontitis and 45 age and sex-matched healthy subjects were enrolled into the study. All subjects received periodontal and hematological examinations. The periodontitis patients were administered active periodontal treatment (APT). At baseline, a statistically significant decrease in MPV was noted in patients with periodontitis (9.73 +/- 1.06 fL) compared with healthy controls (10.24 +/- 1.07 fL). At 1 month post-APT, MPV was substantially increased (10.11 +/- 1.04 fL). Positive correlation was found between increase of MPV and decrease of periodontal probing depth after treatment(r = 0.377; p = 0.014). In conclusion, the decrease of MPV was related to the severe periodontal inflammation, and the value inversed shift after APT. MPV might reflect the disease activity of periodontitis.

语种英语
WOS记录号WOS:000348147300013
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50276
专题北京大学口腔医学院_牙周科
作者单位Peking Univ Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xian&prime,e,Meng, Huanxin,et al. Mean platelet volume as an inflammatory marker in patients with severe periodontitis[J]. PLATELETS,2015,26(1):67-71.
APA Wang, Xian&prime.,e.,Meng, Huanxin.,Xu, Li.,Chen, Zhibin.,...&Lv, Da.(2015).Mean platelet volume as an inflammatory marker in patients with severe periodontitis.PLATELETS,26(1),67-71.
MLA Wang, Xian&prime,et al."Mean platelet volume as an inflammatory marker in patients with severe periodontitis".PLATELETS 26.1(2015):67-71.
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