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学科主题: 临床医学
题名:
Involvement of bone marrow in lymphoma: pathological investigation in a single-center from Northern China
作者: Shi, Yun-Fei2; Li, Xiang-Hong2; Song, Yu-Qin3; Song, Wei-Wei3; Lai, Yu-Mei2
关键词: Lymphoma ; bone marrow ; involvement ; pathology ; Chinese
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
发表日期: 2015
卷: 8, 期:6, 页:7102-7111
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: NON-HODGKIN LYMPHOMAS ; CELL LYMPHOMA ; BIOPSY INVOLVEMENT ; TREPHINE BIOPSY ; CLASSIFICATION ; INFILTRATION ; SPECIMENS ; DIAGNOSIS ; FEATURES
英文摘要:

Objectives: This study aimed to evaluate key features of bone marrow trephine biopsy (BMT) involvement of lymphoma in Northern China. Methods: 950 cases were assessed for the occurrence of bone marrow involvement and architectural features including volume percentage, involvement pattern (diffuse, nodular, focal, para trabecular, or interstitial), and presence/absence of background changes (granuloma, stromal fibrosis or necrosis). Correlations with bone marrow aspirate (BMA) and flow cytometry (FCM) findings were made in a subset of paired cases (359 BMA and 364 FCM). Results: 153 (16.1%) cases involved BMT. The most frequent type was mantle cell lymphoma (28/153, 18.3%). Architectural features were similar to previous studies except that diffuse large B-cell lymphoma (DLBCL) preferred focal pattern (16/22 cases, 72.7%) most of all. BMA and BMT agreed in 84.1% of cases (302 of 359: 277 both negative, 25 both positive), while FCM and BMT agreed in 80.8% of cases (294 of 364: 242 both negative, 52 both positive). Both varied widely among different subgroups. Conclusions: Occurrence of BMT involvement by lymphoma in Northern China is relatively low. The volume percentage, distribution patterns and background changes may be useful pointers towards a particular lymphoma type in Chinese. FCM is more sensitive and reliable than BMA in China.

语种: 英语
WOS记录号: WOS:000359277700126
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50282
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Pathol, Beijing 100142, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Lymphoma, Beijing 100142, Peoples R China

Recommended Citation:
Shi, Yun-Fei,Li, Xiang-Hong,Song, Yu-Qin,et al. Involvement of bone marrow in lymphoma: pathological investigation in a single-center from Northern China[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2015,8(6):7102-7111.
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