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学科主题临床医学
The clinical value of in vivo confocal microscopy for diagnosis of ocular surface squamous neoplasia
Xu, Y.1; Zhou, Z.1; Xu, Y.2; Wang, M.1; Liu, F.1; Qu, H.1; Hong, J.1
关键词In Vivo Confocal Microscopy Diagnosis Ocular Surface Squamous Neoplasia
刊名EYE
2012-06-01
DOI10.1038/eye.2012.15
26期:6页:781-787
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]CONJUNCTIVAL INTRAEPITHELIAL NEOPLASIA ; CELL-CARCINOMA ; IMPRESSION CYTOLOGY ; MITOMYCIN-C ; TOPICAL INTERFERON-ALPHA-2B ; PATIENT ; SITU ; TUMORS ; EYE
英文摘要

Purpose To determine the reliability and efficiency of in vivo confocal microscopy for the diagnosis of ocular surface squamous neoplasia (OSSN).

Methods A case series with five consecutive cases of OSSN were investigated retrospectively, of which the characteristics and subspecial types had been estimated by in vivo confocal microscopy before surgery. The structure and cellular features of OSSN were analyzed with other examinations, such as anterior-segment optical coherence tomography (AS-OCT), and confirmed by histopathological biopsy.

Results The tumors revealed red gelatinous surfaces with vascular dilatation on the ocular surface of the conjunctival and corneal epithelium in anterior segment photography. Involvement of only corneal epithelium was observed by AS-OCT in three cases, whereas the Bowman′s layer and anterior stroma were also invaded in the other two cases. In vivo confocal microscopy showed cellular anisocytosis and enlarged nuclei with high nuclear to cytoplasmic ratio in three cases diagnosed as conjunctival intraepithelial neoplasia; moreover, nests were partially formed by isolated keratinized, binucleated, and actively mitotic dysmorphic epithelial cells in the other two cases diagnosed as carcinoma in situ and ocular surface squamous carcinoma (OSSC). The characteristics assessed from histopathological biopsy were similar to that revealed by in vivo confocal microscopy in all five cases.

Conclusion In vivo confocal microscopy analysis of cytological characteristics of OSSN is a safe, relatively noninvasive, and effective diagnostic tool in detecting characteristics of OSSN before surgical resection. Although in vivo confocal microscopy cannot replace excisional biopsy for definitive diagnosis, it can be valuable for initial diagnosis and management of patients with OSSN. Eye (2012) 26, 781-787; doi:10.1038/eye.2012.15; published online 9 March 2012

语种英语
WOS记录号WOS:000305389400003
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50289
专题北京大学临床肿瘤学院_乳腺中心实验室
北京大学第三临床医学院_眼科
作者单位1.Peking Univ Third Hosp, Peking Univ Eye Ctr, Dept Ophthalmol, Beijing 100191, Peoples R China
2.Peking Univ Third Hosp, Clin Stem Cell Res Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Xu, Y.,Zhou, Z.,Xu, Y.,et al. The clinical value of in vivo confocal microscopy for diagnosis of ocular surface squamous neoplasia[J]. EYE,2012,26(6):781-787.
APA Xu, Y..,Zhou, Z..,Xu, Y..,Wang, M..,Liu, F..,...&Hong, J..(2012).The clinical value of in vivo confocal microscopy for diagnosis of ocular surface squamous neoplasia.EYE,26(6),781-787.
MLA Xu, Y.,et al."The clinical value of in vivo confocal microscopy for diagnosis of ocular surface squamous neoplasia".EYE 26.6(2012):781-787.
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