IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
The Changes in Residual Cancer Burden after Interval Debulking Surgery Are Effective in Evaluating the Response to Adjuvant Chemotherapy
Kong, Lili1,2; Li, Xiaoping1; Xu, Qiying1; Wei, Lihui1; Wang, Jianliu1; Cui, Heng1; Wang, Shijun1; Zhao, Yan1
关键词Ovarian Malignant Tumor Adjuvant Chemotherapy Cancer Burden Residual Debulking Surgery Primary Debulking Surgery Interval
刊名CHEMOTHERAPY
2011
DOI10.1159/000323625
57期:3页:209-216
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pharmacology & Pharmacy
研究领域[WOS]Oncology ; Pharmacology & Pharmacy
关键词[WOS]EPITHELIAL OVARIAN-CANCER ; SURVIVAL ; CA-125 ; CARCINOMA
英文摘要

Objective: To study the clinical significance of the change of residual cancer burden (RCB) of epithelial ovarian carcinoma (EOC) between primary (PDS) and interval debulking surgery (IDS) in order to evaluate the effectiveness of adjuvant chemotherapy. Methods: Thirty-eight EOC patients with suboptimal PDS with adjuvant chemotherapy were selected for this retrospective study and divided into pathologically negative (group A) and pathologically positive (group B) groups based on the histopathological examination and the change of size of residual disease after IDS. Patients in group B were further divided into groups B1 (partial remission criteria, n = 9), B2 (consistent with stable disease, n = 12) and B3 (consistent with disease progression, n = 4) based on the changes in RCB between PDS and IDS and the guidelines to evaluate the response to treatment in solid tumors (Response Evaluation Criteria in Solid Tumors, RECIST). The responses to che- motherapy evaluated by pathological examination of RCB versus by CA-125, recurrence patterns, and prognoses were analyzed. Results: The clinical benefit rates evaluated by pathological assessment for groups A, B1, B2 and B3 were 100, 100, 100 and 0%, respectively (p < 0.01), whereas the rates were not statistically different when evaluated by CA-125 (100, 100, 91.7 and 100%, respectively; p > 0.05). The median progression-free survival (PFS) for patients in groups A and B was 36 and 6 months, respectively (p < 0.05); the median overall survival (OS) was 93 and 42 months, respectively (p < 0.05). There were no significant differences in median PFS or OS among patients in groups B1, B2 and B3 (PFS: 16, 6 and 1.5 months; OS: 52, 31 and 30.5 months, respectively; all p > 0.05), but there were significant differences in median PFS or OS between B1 and B3. There was no significant difference in recurrence rates between groups A and B (53.8 vs. 72.0%, p > 0.05), but there were significant differences in the rate of drug-resistant recurrence [28.6% (2/7) vs. 72.2% (13/18), p < 0.05] and in median PFS of relapsed patients (19 vs. 4 months, p < 0.05). Conclusion: The histopathological assessment of RCB between PDS and IDS may be used to evaluate and predict the response to adjuvant chemotherapy in EOC. Copyright (C) 2011 S. Karger AG, Basel

语种英语
WOS记录号WOS:000291159500005
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50290
专题北京大学第二临床医学院
北京大学临床肿瘤学院_重症监护病区
作者单位1.Peking Univ, Peoples Hosp, Dept Gynaecol, Beijing 100044, Peoples R China
2.Peking Univ, ShouGang Hosp, Dept Obstet & Gynaecol, Beijing 100044, Peoples R China
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GB/T 7714
Kong, Lili,Li, Xiaoping,Xu, Qiying,et al. The Changes in Residual Cancer Burden after Interval Debulking Surgery Are Effective in Evaluating the Response to Adjuvant Chemotherapy[J]. CHEMOTHERAPY,2011,57(3):209-216.
APA Kong, Lili.,Li, Xiaoping.,Xu, Qiying.,Wei, Lihui.,Wang, Jianliu.,...&Zhao, Yan.(2011).The Changes in Residual Cancer Burden after Interval Debulking Surgery Are Effective in Evaluating the Response to Adjuvant Chemotherapy.CHEMOTHERAPY,57(3),209-216.
MLA Kong, Lili,et al."The Changes in Residual Cancer Burden after Interval Debulking Surgery Are Effective in Evaluating the Response to Adjuvant Chemotherapy".CHEMOTHERAPY 57.3(2011):209-216.
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