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学科主题: 基础医学
题名:
Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT1A receptors
作者: Wang, L. -E.1; Cui, X. -Y.1; Cui, S. -Y.1; Cao, J. -X.1; Zhang, J.1; Zhang, Y. -H.1; Zhang, Q. -Y.2; Bai, Y. -J.2; Zhao, Y. -Y.2
关键词: Spinosin ; Semen Ziziphi spinosae ; Pentobarbital-induced sleep ; 8-OH-DPAT ; p-MPPI ; 5-HT1A receptor
刊名: PHYTOMEDICINE
发表日期: 2010-05-01
DOI: 10.1016/j.phymed.2010.01.014
卷: 17, 期:6, 页:404-409
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]: ANTAGONIST P-MPPI ; DORSAL RAPHE NUCLEUS ; FREELY MOVING RAT ; AGONIST 8-OH-DPAT ; MICRODIALYSIS PERFUSION ; WAKEFULNESS ; BRAIN ; AUTORECEPTORS ; BLOCKS ; WAKING
英文摘要:

Previous results have suggested that spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, potentiates pentobarbital-Induced sleep via the serotonergic system. The present study investigated whether spinosin potentiates pentobarbital-induced sleep via serotonin-1A (5-hydroxytryptamine, 5-HT1A) receptors The results demonstrated that spinosin significantly augmented pentobarbital (35 mg/kg, i p)-induced sleep in rats, reflected by reduced sleep latency and increased total sleep time, non-rapid eye movement (NREM) sleep time, and REM sleep time With regard to NREM sleep duration, spinosin mainly increased slow-wave sleep (SWS). Additionally, spinosin (15 mg/kg, i g.) significantly antagonized 5-HT1A agonist 8-OH-DPAT (0.1 mg/kg, i.p.)-induced reductions in total sleep time, NREM sleep, REM sleep, and SWS in pentobarbital-treated rats. These results suggest that spinosin may be an antagonist at postsynaptic 5-HT1A receptors because these effects of 8-OH-DPAT were considered to be mediated via postsynaptic 5-HT1A receptors. Moreover, co-administration of spinosin and the 5-HT1A antagonist 4-iodo-N-{2-[4-(methoxyphenyl)-1-piperazinyl]ethyl}-N-2-pyridinylbenzamide (p-MPPI), at doses that are ineffective when administered alone (spinosin 5 mg/kg, p-MPPI 1 mg/kg), had significant augmentative effects on pentobarbital-induced sleep, reflected by reduced sleep latency and increased total sleep time, NREM sleep, and REM sleep In contrast to the attenuating effects of p-MPPI on REM sleep via presynaptic 5-HT1A autoreceptors, 15 mg/kg spinosin significantly increased REM sleep These results suggest that the effect of spinosin on REM sleep in pentobarbital-treated rats may be related to postsynaptic 5-HT1A receptors (C) 2010 Elsevier GmbH All rights reserved

语种: 英语
所属项目编号: 30640070 ; 30772556
项目资助者: National Natural Science Foundation of China (NSFC) ; Janssen Research Council (JRCC) ; Peking University
WOS记录号: WOS:000278701100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50295
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China

Recommended Citation:
Wang, L. -E.,Cui, X. -Y.,Cui, S. -Y.,et al. Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT1A receptors[J]. PHYTOMEDICINE,2010,17(6):404-409.
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