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Region-specific effects of brain corticotropin-releasing factor receptor type 1 blockade on footshock-stress- or drug-priming-induced reinstatement of morphine conditioned place preference in rats
Wang, JS1; Fang, Q1; Liu, ZH1; Lu, L1
关键词Amygdala Bed Nucleus Of The Stria Terminalis Corticotropin-releasing Factor Conditioned Place Preference Nucleus Accumbens Opiate Reinstatement Relapse
刊名PSYCHOPHARMACOLOGY
2006-03-01
DOI10.1007/s00213-005-0262-6
185期:1页:19-28
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]COCAINE-INDUCED REINSTATEMENT ; INDUCED RELAPSE ; STRIA TERMINALIS ; BED NUCLEUS ; SEEKING BEHAVIOR ; NONPEPTIDE ANTAGONIST ; INDUCED REACTIVATION ; OPIATE WITHDRAWAL ; HEROIN-SEEKING ; DOPAMINE
英文摘要

Rationale: Systemic injections of the selective corticotropin-releasing factor 1 (CRF1) receptor antagonist CP-154,526 attenuate footshock-stress-induced reinstatement of heroin and cocaine seeking and morphine conditioned place preference (CPP). Intracranial injections of the nonselective CRF receptor antagonist D-Phe-CRF into the bed nucleus of the stria terminalis (BNST), but not the amygdala, attenuate footshock-induced reinstatement of cocaine seeking. However, the brain sites involved in the effect of CP-154,526 on footshock-induced reinstatement of opiate seeking are unknown. Objective: We used a CPP version of the reinstatement model to examine the role of CRF1 receptors in the BNST, amygdala, and nucleus accumbens (NAc) in footshock- or drug-priming-induced reinstatement of extinguished morphine CPP. Methods: Rats acquired morphine CPP over a period of 8 days during which they were given four morphine (10 mg/kg s.c.) and four saline injections and were subsequently confined to distinct chambers for 50 min. Subsequently, the morphine CPP was extinguished in 14 daily sessions during which rats were given saline injections and given access to both the saline- and morphine-paired chambers. The rats were then tested for reinstatement of morphine CPP induced by priming injections of morphine (0 or 3.0 mg/ kg s.c.) or by exposure to intermittent footshock (15 min, 0.5 mA). Prior to the test sessions, the rats were given intracranial injections of CP-154,526 (1.0 mu g) or vehicle into the BNST, amygdala, or NAc. Results: CP-154,526 injections into the BNST, but not the amygdala or NAc, attenuated footshock-stress-induced reinstatement of morphine CPP. In contrast, CP-154,526 injections into the amygdala or NAc, but not the BNST, attenuated morphine-priming-induced reinstatement of morphine CPP. Conclusion: The present results demonstrate dissociable roles of CRF1 receptors in the BNST, amygdala, and NAc in footshock-stress- vs morphine-priming-induced reinstatement of drug CPP.

语种英语
WOS记录号WOS:000235547600003
Citation statistics
Cited Times:85[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50296
Collection中国药物依赖性研究所
作者单位1.NIDA, Behav Neurosci Branch, IRP, NIH,DHHS, Baltimore, MD 21224 USA
2.Guiyang Med Coll, Affiliated Hosp, Dept Pharmacol, Guiyang 550004, Peoples R China
3.New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA
4.Fudan Univ, Shanghai Med Sch, Natl Lab Med Neurobiol, Shanghai 200032, Peoples R China
5.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Wang, JS,Fang, Q,Liu, ZH,et al. Region-specific effects of brain corticotropin-releasing factor receptor type 1 blockade on footshock-stress- or drug-priming-induced reinstatement of morphine conditioned place preference in rats[J]. PSYCHOPHARMACOLOGY,2006,185(1):19-28.
APA Wang, JS,Fang, Q,Liu, ZH,&Lu, L.(2006).Region-specific effects of brain corticotropin-releasing factor receptor type 1 blockade on footshock-stress- or drug-priming-induced reinstatement of morphine conditioned place preference in rats.PSYCHOPHARMACOLOGY,185(1),19-28.
MLA Wang, JS,et al."Region-specific effects of brain corticotropin-releasing factor receptor type 1 blockade on footshock-stress- or drug-priming-induced reinstatement of morphine conditioned place preference in rats".PSYCHOPHARMACOLOGY 185.1(2006):19-28.
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