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Marine collagen peptides protect against early alcoholic liver injury in rats
Lin, Bing; Zhang, Feng; Yu, Yongchao; Jiang, Qinghao; Zhang, Zhaofeng; Wang, Junbo; Li, Yong
关键词Marine Collagen Peptides Alcoholic Liver Injury Antioxidants Lipid Metabolism
刊名BRITISH JOURNAL OF NUTRITION
2012-04-01
DOI10.1017/S0007114511004211
107期:8页:1160-1166
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
资助者Foundation from Ministry of Science and Technology of the People&prime ; s Republic of China ; Foundation from Ministry of Science and Technology of the People&prime ; s Republic of China
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]BLOOD-LIPIDS ; FATTY LIVER ; EXTRACT PROTECTS ; HEPATIC DAMAGE ; DISEASE ; MICE ; PATHOGENESIS ; ETHANOL ; MECHANISMS ; FIBROSIS
英文摘要

Marine collagen peptides (MCP) have been reported to exhibit antioxidative activity, which is the common property of numerous hepatoprotective agents. Previous studies have shown that MCP have biological functions including anti-hypertension, anti-ulcer, anti-skin ageing and extending the life span. However, its role in alcoholic liver injury remains unknown. The present study aimed to investigate the effects of MCP on early alcoholic liver injury in rats. Rats were administered with alcohol at a dose of 6 g/kg body weight intragastrically per d to induce early liver injury, which was then evaluated by serum markers and histopathological examination. Treatment with MCP could reverse the increased level of serum aminotransferase and reduce hepatic histological damage. In addition, MCP attenuated the alteration in serum superoxide dismutase and malondialdehyde levels. MCP also counteracted the increased levels of total cholesterol and TAG. However, no significant difference was observed in the contents of alcohol dehydrogenase both in liver and serum protein of rats. These findings suggest that MCP have a protective effect on early alcoholic liver injury in rats by their antioxidative activity and improving lipid metabolism.

语种英语
所属项目编号2006BAD27B08
资助者Foundation from Ministry of Science and Technology of the People&prime ; s Republic of China ; Foundation from Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号WOS:000304242800008
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50302
Collection北京大学公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Lin, Bing,Zhang, Feng,Yu, Yongchao,et al. Marine collagen peptides protect against early alcoholic liver injury in rats[J]. BRITISH JOURNAL OF NUTRITION,2012,107(8):1160-1166.
APA Lin, Bing.,Zhang, Feng.,Yu, Yongchao.,Jiang, Qinghao.,Zhang, Zhaofeng.,...&Li, Yong.(2012).Marine collagen peptides protect against early alcoholic liver injury in rats.BRITISH JOURNAL OF NUTRITION,107(8),1160-1166.
MLA Lin, Bing,et al."Marine collagen peptides protect against early alcoholic liver injury in rats".BRITISH JOURNAL OF NUTRITION 107.8(2012):1160-1166.
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