IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Marine collagen peptides protect against early alcoholic liver injury in rats
Lin, Bing; Zhang, Feng; Yu, Yongchao; Jiang, Qinghao; Zhang, Zhaofeng; Wang, Junbo; Li, Yong
关键词Marine Collagen Peptides Alcoholic Liver Injury Antioxidants Lipid Metabolism
刊名BRITISH JOURNAL OF NUTRITION
2012-04-01
DOI10.1017/S0007114511004211
107期:8页:1160-1166
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
资助者Foundation from Ministry of Science and Technology of the People&prime ; s Republic of China ; Foundation from Ministry of Science and Technology of the People&prime ; s Republic of China
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]BLOOD-LIPIDS ; FATTY LIVER ; EXTRACT PROTECTS ; HEPATIC DAMAGE ; DISEASE ; MICE ; PATHOGENESIS ; ETHANOL ; MECHANISMS ; FIBROSIS
英文摘要

Marine collagen peptides (MCP) have been reported to exhibit antioxidative activity, which is the common property of numerous hepatoprotective agents. Previous studies have shown that MCP have biological functions including anti-hypertension, anti-ulcer, anti-skin ageing and extending the life span. However, its role in alcoholic liver injury remains unknown. The present study aimed to investigate the effects of MCP on early alcoholic liver injury in rats. Rats were administered with alcohol at a dose of 6 g/kg body weight intragastrically per d to induce early liver injury, which was then evaluated by serum markers and histopathological examination. Treatment with MCP could reverse the increased level of serum aminotransferase and reduce hepatic histological damage. In addition, MCP attenuated the alteration in serum superoxide dismutase and malondialdehyde levels. MCP also counteracted the increased levels of total cholesterol and TAG. However, no significant difference was observed in the contents of alcohol dehydrogenase both in liver and serum protein of rats. These findings suggest that MCP have a protective effect on early alcoholic liver injury in rats by their antioxidative activity and improving lipid metabolism.

语种英语
所属项目编号2006BAD27B08
资助者Foundation from Ministry of Science and Technology of the People&prime ; s Republic of China ; Foundation from Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号WOS:000304242800008
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50302
专题北京大学公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Lin, Bing,Zhang, Feng,Yu, Yongchao,et al. Marine collagen peptides protect against early alcoholic liver injury in rats[J]. BRITISH JOURNAL OF NUTRITION,2012,107(8):1160-1166.
APA Lin, Bing.,Zhang, Feng.,Yu, Yongchao.,Jiang, Qinghao.,Zhang, Zhaofeng.,...&Li, Yong.(2012).Marine collagen peptides protect against early alcoholic liver injury in rats.BRITISH JOURNAL OF NUTRITION,107(8),1160-1166.
MLA Lin, Bing,et al."Marine collagen peptides protect against early alcoholic liver injury in rats".BRITISH JOURNAL OF NUTRITION 107.8(2012):1160-1166.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lin, Bing]的文章
[Zhang, Feng]的文章
[Yu, Yongchao]的文章
百度学术
百度学术中相似的文章
[Lin, Bing]的文章
[Zhang, Feng]的文章
[Yu, Yongchao]的文章
必应学术
必应学术中相似的文章
[Lin, Bing]的文章
[Zhang, Feng]的文章
[Yu, Yongchao]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。