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学科主题: 临床医学
题名:
Sandwich sign of Borrmann type 4 gastric cancer on diffusion-weighted magnetic resonance imaging
作者: Zhang, Xiao-Peng1; Tang, Lei1; Sun, Ying-Shi1; Li, Zi-Yu2; Ji, Jia-Fu2; Li, Xiao-Ting1; Liu, Yi-Qiang3; Wu, Qi4
关键词: Magnetic resonance imaging ; Diffusion-weighted imaging ; Apparent diffusion coefficient ; Stomach neoplasm
刊名: EUROPEAN JOURNAL OF RADIOLOGY
发表日期: 2012-10-01
DOI: 10.1016/j.ejrad.2011.10.021
卷: 81, 期:10, 页:2481-2486
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: CERVICAL-CANCER ; TUMOR-DETECTION ; CARCINOMA ; STAGE
英文摘要:

Objective: To assess the appearance of Borrmann type 4 (BT-4) gastric cancer on diffusion-weighted magnetic resonance imaging (DWI) and to investigate the potential of qualitative and quantitative DW images analysis to differentiate BT-4 gastric cancer from poorly distended normal stomach wall.

Materials and methods: DWI was performed on 23 patients with BT-4 gastric cancer and 23 healthy volunteers. The signal characteristics and correlated histopathological basis of the cancers on DWI were investigated. The contrast-to-noise ratios (CNR) of cancer were compared between DWI and T1WI/T2WI. The thickness and apparent diffusion coefficient (ADC) of cancer and normal stomach wall were compared.

Results: All of the gastric cancers displayed hyperintensity compared to the nearby normal gastric wall on DWI. A three-layer sandwich sign that demonstrated high signal intensity in the inner and outer layer, and low signal intensity in the intermediate layer was observed in 69.6% of cancers on DWI. The low signal intensity represents the muscularis propria through the comparison with pathology, and it is postulated that scattering distribution of the cancer cells in this layer causes less damage and subsequently less restriction of water movement, which causes the low signal intensity on DWI. The CNR obtained with DWI was higher than that with T1WI and T2WI (P < 0.001). The mean ADC value of BT-4 gastric cancer was significantly lower than the poorly distended normal stomach wall (1.12 +/- 0.23 x 10(-3) mm(2)/s vs. 1.93 +/- 0.22 x 10(-3) mm(2)/s, P < 0.01).

Conclusion: DWI can highlight the signals of BT-4 gastric cancer which may present a characteristic three-layer sandwich sign, and ADC values are helpful in the discrimination of gastric cancer from poorly distended stomach wall. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2011CB707705 ; 30970825 ; 7092020
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing, China
WOS记录号: WOS:000308079700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50305
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Radiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Gastrointestinal Surg, Beijing 100142, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Pathol, Beijing 100142, Peoples R China
4.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Endoscopy, Beijing 100142, Peoples R China

Recommended Citation:
Zhang, Xiao-Peng,Tang, Lei,Sun, Ying-Shi,et al. Sandwich sign of Borrmann type 4 gastric cancer on diffusion-weighted magnetic resonance imaging[J]. EUROPEAN JOURNAL OF RADIOLOGY,2012,81(10):2481-2486.
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