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IR@PKUHSC  > 北京大学第二临床医学院  > 眼科  > 期刊论文
学科主题: 临床医学
题名:
Apelin in Plasma and Vitreous and in Fibrovascular Retinal Membranes of Patients with Proliferative Diabetic Retinopathy
作者: Tao, Yong1,2; Lu, Qiang1; Jiang, Yan-Rong1; Qian, Jing1; Wang, Jia-Yan1; Gao, Lei3,4; Jonas, Jost B.2
刊名: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
发表日期: 2010-08-01
DOI: 10.1167/iovs.09-4466
卷: 51, 期:8, 页:4237-4242
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: VASCULAR DEVELOPMENT ; ENDOTHELIAL-CELLS ; ANGIOGENIC FACTOR ; RECEPTOR APJ ; LIGAND ; EXPRESSION ; EYE
英文摘要:

PURPOSE. Apelin is an endogenous ligand for the angiotensin-1-like receptor APJ. Because apelin has been reported to regulate angiogenesis, the authors searched for associations between apelin and proliferative diabetic retinopathy.

METHODS. The study included 55 patients undergoing vitrectomy for proliferative diabetic retinopathy (study group) and 34 patients undergoing vitrectomy for idiopathic preretinal membranes or macular hole (control group). Using enzyme-linked immunosorbent assay, the authors measured the concentrations of apelin and vascular endothelial growth factor (VEGF) in the vitreous and plasma. The expression of apelin and angiotensin-1-like receptor APJ in the excised membranes was examined by fluorescence immunostaining and semiquantitative reverse transcription polymerase chain reaction.

RESULTS. Vitreous concentrations of apelin were significantly higher in the study group than in the control group (P = 0.005), whereas plasma concentrations of apelin did not vary significantly (P = 0.66). The vitreous concentrations (P < 0.001) and the plasma concentrations (P = 0.03) of VEGF were significantly higher in the study group than in the control group. Neither the vitreous concentrations of apelin and VEGF (P = 0.47) nor the plasma concentrations of apelin and VEGF (P = 0.19) were significantly associated with each other. In the fibrovascular membranes of the study group, colocalization of the endothelial markers CD31 with the markers for apelin and colocalization of the endothelial markers CD31 and APJ was observed. Expression of apelin mRNA (P = 0.03), APJ mRNA (P = 0.02), and VEGF mRNA (P < 0.01) was significantly higher in fibrovascular proliferative diabetic retinopathy membranes than in idiopathic epiretinal membranes.

CONCLUSIONS. The apelin/APJ system may be involved in retinal neovascularization during the development of proliferative diabetic retinopathy. (Invest Ophthalmol Vis Sci. 2010; 51: 4237-4242) DOI:10.1167/iovs.09-4466

语种: 英语
所属项目编号: 30901639 ; 2009B04 ; RDB2009-42
项目资助者: National Natural Science Foundation of China ; Beijing Novel Program ; People&prime ; s Hospital of Peking University ; Deutsche Diabetes Gesellschaft, Duesseldorf, Germany ; German Academic Exchange Service (Bonn, Germany)
WOS记录号: WOS:000280194100057
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50307
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Univ Heidelberg, Med Fac Mannheim, Dept Ophthalmol, Heidelberg, Germany
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
3.Chinese Acad Med Sci, Inst Pathogen Biol, Beijing 100037, Peoples R China
4.Peking Union Med Coll, Beijing 100021, Peoples R China

Recommended Citation:
Tao, Yong,Lu, Qiang,Jiang, Yan-Rong,et al. Apelin in Plasma and Vitreous and in Fibrovascular Retinal Membranes of Patients with Proliferative Diabetic Retinopathy[J]. INVESTIGATIVE OPHTHALMOLOGY &amp; VISUAL SCIENCE,2010,51(8):4237-4242.
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