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RP-HPLC determination and pharmacokinetic comparison of cinnamic acid in rat plasma after administration of Di-Gu-Pi decoction and pure cinnamic acid
Li, K1; Bi, KS1
关键词Di-gu-pi Decoction Cinnamic Acid Pharmacokinetics Rp-hplc
刊名CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
2006
22期:1页:56-60
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
英文摘要

A sensitive, simple, and accurate method was developed for the determination and pharmacokinetic comparison of cinnamic acid in rat plasma after the administration of a Traditional Chinese Medicinal preparation, Di-Gu-Pi decoction, and pure cinnamic acid using RP-HPLC. Di-Gu-Pi was extracted with 5% aqueous sodium bicarbonate, which was followed by purification with ion exchange column chromatography. The plasma samples taken from rats were deproteinized with methanol. The reversed-phase (HPLC) system with a Diamonsil C, column and methanol-acetonitrile-water (8:32:60, volume ratio) ( adjusted to pH = 3.0 with glacial acetic acid) as the mobile phase was employed for the separation of cinnamic acid in the plasma samples. The detection was set at 272 nm and 3-(p-fluorophenyl)-2-propenoic acid was chosen as the internal standard. The calibration curve was linear in a range from 0.10 to 25.0 mu g/mL (R-2 = 0.9988, n = 9). The precision was 3.42%-10.10% ; the between-day precision was 2.84%-8.91%; the accuracy was 1.51%-1.26% the mean recovery was 99.9%. The method was found to be sensitive, simple, accurate and appropriate for the determination of cinnamic acid.

语种英语
WOS记录号WOS:000235181400014
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50314
专题北京大学深圳医院_药学部
作者单位1.Beijing Univ, Shenzhen Hosp, Dept Pharm, Shenzhen 518036, Peoples R China
2.Shenyang Pharmaceut Univ, Coll Pharm, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714
Li, K,Bi, KS. RP-HPLC determination and pharmacokinetic comparison of cinnamic acid in rat plasma after administration of Di-Gu-Pi decoction and pure cinnamic acid[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2006,22(1):56-60.
APA Li, K,&Bi, KS.(2006).RP-HPLC determination and pharmacokinetic comparison of cinnamic acid in rat plasma after administration of Di-Gu-Pi decoction and pure cinnamic acid.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,22(1),56-60.
MLA Li, K,et al."RP-HPLC determination and pharmacokinetic comparison of cinnamic acid in rat plasma after administration of Di-Gu-Pi decoction and pure cinnamic acid".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 22.1(2006):56-60.
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