IR@PKUHSC  > 北京大学第三临床医学院  > 麻醉科
学科主题临床医学
Pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese surgical patients
Zhao Yan2; Wu Xin-min3; Duan Jing-li1; Sheng Xiao-yan1; Liu Wei1; Lu Wei4; Zhang Li-ping2; Xu Chuan-ya2
关键词Sufentanil Pharmacokinetics Target-controlled Infusion Tandem Mass Spectrometry Mixed-effect Model
刊名CHINESE MEDICAL JOURNAL
2009-02-05
DOI10.3760/cma.j.issn.0366-6999.2009.03.010
122期:3页:291-295
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]EPIDURAL ANALGESIA ; HUMAN PLASMA ; SURGERY ; REMIFENTANIL ; ANESTHESIA ; PROPOFOL ; ADULTS ; TRIAL
英文摘要

Background Target-controlled infusion (TCI) has been recently developed and successfully implemented in clinical practice. This study was conducted to determine the pharmacokinetics of TCI administered sufentanil in Chinese surgical patients.

Methods The pharmacokinetics of sufentanil was investigated in 12 adult patients, aged 23-76 years, scheduled for prolonged surgery under general anesthesia. Anesthetic induction was carried out with propofol, rocuronium and TCI administered sufentanil aiming for target effect-site concentration of sufentanil 4 or 6 ng/ml. Sufentanil TCI lasted for 30 minutes. Frequent arterial blood samples (1.5 ml) were drawn during and up to 24 hours after sufentanil TCI. Plasma sufentanil concentrations were measured by liquid chromatography-tandem mass spectrometry; limit of sensitivity of mass spectrometry was 5 pg/ml. The data were analyzed with the nonlinear mixed-effect model program.

Results The pharmacokinetics of TO administered sufentanil were optimally described by a three-compartment model with the following parameters: the central volume of distribution (V(1)) = 5.4 L, the volume of distribution at steady-state (Vdss) = 195.4 L, systemic clearance (Cl(1)) = 1.10 L/min, and elimination half-life (t(1/2) gamma) = 271.8 minutes. Both age and gender affected the pharmacokinetic parameters. The rapid distribution clearance (Cl(2)) was negatively correlated with patient age, and the volume of slowly equilibrating compartment (V(3)) was positively correlated with age. The Cl(2) and the volume of rapidly equilibrating compartment (V(2)) were influenced by gender with male patients showing higher values of Cl(2) and V(2) than female patients. There was no relationship of body weight, lean body mass, plasma albumin, or target effect-site concentration of sufentanil with any of the pharmacokinetic parameters studied.

Conclusions The pharmacokinetics of TCI administered sufentanil in Chinese patients can be adequately described by a three-compartment model. Pharmacokinetics adjusted to the individual patient should improve the accuracy of TCI systems.

语种英语
WOS记录号WOS:000263313200010
项目编号YZZ07-7-11
资助机构Peking University Third Hospital
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50316
专题北京大学第三临床医学院_麻醉科
北京大学药学院_药剂学系
北京大学第三临床医学院_药剂科
作者单位1.Peking Univ, Hosp 3, Dept Pharm, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 1, Dept Anesthesiol, Beijing 100034, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhao Yan,Wu Xin-min,Duan Jing-li,et al. Pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese surgical patients[J]. CHINESE MEDICAL JOURNAL,2009,122(3):291-295.
APA Zhao Yan.,Wu Xin-min.,Duan Jing-li.,Sheng Xiao-yan.,Liu Wei.,...&Xu Chuan-ya.(2009).Pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese surgical patients.CHINESE MEDICAL JOURNAL,122(3),291-295.
MLA Zhao Yan,et al."Pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese surgical patients".CHINESE MEDICAL JOURNAL 122.3(2009):291-295.
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