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学科主题: 临床医学
题名:
Pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese surgical patients
作者: Zhao Yan2; Wu Xin-min3; Duan Jing-li1; Sheng Xiao-yan1; Liu Wei1; Lu Wei4; Zhang Li-ping2; Xu Chuan-ya2
关键词: sufentanil ; pharmacokinetics ; target-controlled infusion ; tandem mass spectrometry ; mixed-effect model
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2009-02-05
DOI: 10.3760/cma.j.issn.0366-6999.2009.03.010
卷: 122, 期:3, 页:291-295
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: EPIDURAL ANALGESIA ; HUMAN PLASMA ; SURGERY ; REMIFENTANIL ; ANESTHESIA ; PROPOFOL ; ADULTS ; TRIAL
英文摘要:

Background Target-controlled infusion (TCI) has been recently developed and successfully implemented in clinical practice. This study was conducted to determine the pharmacokinetics of TCI administered sufentanil in Chinese surgical patients.

Methods The pharmacokinetics of sufentanil was investigated in 12 adult patients, aged 23-76 years, scheduled for prolonged surgery under general anesthesia. Anesthetic induction was carried out with propofol, rocuronium and TCI administered sufentanil aiming for target effect-site concentration of sufentanil 4 or 6 ng/ml. Sufentanil TCI lasted for 30 minutes. Frequent arterial blood samples (1.5 ml) were drawn during and up to 24 hours after sufentanil TCI. Plasma sufentanil concentrations were measured by liquid chromatography-tandem mass spectrometry; limit of sensitivity of mass spectrometry was 5 pg/ml. The data were analyzed with the nonlinear mixed-effect model program.

Results The pharmacokinetics of TO administered sufentanil were optimally described by a three-compartment model with the following parameters: the central volume of distribution (V(1)) = 5.4 L, the volume of distribution at steady-state (Vdss) = 195.4 L, systemic clearance (Cl(1)) = 1.10 L/min, and elimination half-life (t(1/2) gamma) = 271.8 minutes. Both age and gender affected the pharmacokinetic parameters. The rapid distribution clearance (Cl(2)) was negatively correlated with patient age, and the volume of slowly equilibrating compartment (V(3)) was positively correlated with age. The Cl(2) and the volume of rapidly equilibrating compartment (V(2)) were influenced by gender with male patients showing higher values of Cl(2) and V(2) than female patients. There was no relationship of body weight, lean body mass, plasma albumin, or target effect-site concentration of sufentanil with any of the pharmacokinetic parameters studied.

Conclusions The pharmacokinetics of TCI administered sufentanil in Chinese patients can be adequately described by a three-compartment model. Pharmacokinetics adjusted to the individual patient should improve the accuracy of TCI systems.

语种: 英语
所属项目编号: YZZ07-7-11
项目资助者: Peking University Third Hospital
WOS记录号: WOS:000263313200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50316
Appears in Collections:北京大学第三临床医学院_药剂科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Pharm, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 1, Dept Anesthesiol, Beijing 100034, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhao Yan,Wu Xin-min,Duan Jing-li,et al. Pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese surgical patients[J]. CHINESE MEDICAL JOURNAL,2009,122(3):291-295.
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