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Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells
Gan, YH1; Shen, YH1; Utama, B1; Wang, J1; Coselli, J1; Wang, XL1
关键词Histone Deacetylase Sp1 Enos Gene Expression Tsa
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2006-02-03
DOI10.1016/j.bbrc.2005.11.151
340期:1页:29-34
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]MESSENGER-RNA ; POSTTRANSCRIPTIONAL REGULATION ; REPRESS TRANSCRIPTION ; CODING REGION ; CANCER-CELLS ; PROTEIN ; MICE ; PROMOTER ; ELEMENTS ; SP1
英文摘要

Inhibition of histone deacetylases by trichostatin A (TSA) has pleiotropic effects on gene expression. We demonstrated that at low dose (0.1 mu g) TSA increased the eNOS mRNA levels, which was followed by a time- and dose-dependent down-regulation. Cycloheximide, a protein synthesis inhibitor, completely abolished TSA-induced decrease in eNOS expression, indicating that new protein synthesis is required for the inhibiting effect. Mevastatin-an inhibitor HMG-CoA reductase and geranylgeranylation reaction dose-dependently antagonized TSA-induced reduction. This mevastatin-mediated antagonism was completely abolished by geranylgeranylpyrophosphate, suggesting that geranylgeranyl modification is needed to activate the eNOS mRNA destabilizing factor-a mechanism responsible for statin-mediated eNOS upregulation. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000234640600005
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50319
专题北京大学口腔医学院
作者单位1.Baylor Coll Med, Michael E DeBakey Dept Surg, Div Cardiothorac Surg, Houston, TX 77030 USA
2.St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX 77030 USA
3.Peking Univ, Sch Stomatol, Lab Mol Biol, Beijing 100081, Peoples R China
4.Peking Univ, Sch Stomatol, Ctr TMJ Disorders, Beijing 100081, Peoples R China
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GB/T 7714
Gan, YH,Shen, YH,Utama, B,et al. Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,340(1):29-34.
APA Gan, YH,Shen, YH,Utama, B,Wang, J,Coselli, J,&Wang, XL.(2006).Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,340(1),29-34.
MLA Gan, YH,et al."Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 340.1(2006):29-34.
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