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学科主题: 口腔医学
题名:
Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells
作者: Gan, YH1; Shen, YH1; Utama, B1; Wang, J1; Coselli, J1; Wang, XL1
关键词: histone deacetylase ; Sp1 ; eNOS ; gene expression ; TSA
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2006-02-03
DOI: 10.1016/j.bbrc.2005.11.151
卷: 340, 期:1, 页:29-34
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: MESSENGER-RNA ; POSTTRANSCRIPTIONAL REGULATION ; REPRESS TRANSCRIPTION ; CODING REGION ; CANCER-CELLS ; PROTEIN ; MICE ; PROMOTER ; ELEMENTS ; SP1
英文摘要:

Inhibition of histone deacetylases by trichostatin A (TSA) has pleiotropic effects on gene expression. We demonstrated that at low dose (0.1 mu g) TSA increased the eNOS mRNA levels, which was followed by a time- and dose-dependent down-regulation. Cycloheximide, a protein synthesis inhibitor, completely abolished TSA-induced decrease in eNOS expression, indicating that new protein synthesis is required for the inhibiting effect. Mevastatin-an inhibitor HMG-CoA reductase and geranylgeranylation reaction dose-dependently antagonized TSA-induced reduction. This mevastatin-mediated antagonism was completely abolished by geranylgeranylpyrophosphate, suggesting that geranylgeranyl modification is needed to activate the eNOS mRNA destabilizing factor-a mechanism responsible for statin-mediated eNOS upregulation. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000234640600005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50319
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Baylor Coll Med, Michael E DeBakey Dept Surg, Div Cardiothorac Surg, Houston, TX 77030 USA
2.St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX 77030 USA
3.Peking Univ, Sch Stomatol, Lab Mol Biol, Beijing 100081, Peoples R China
4.Peking Univ, Sch Stomatol, Ctr TMJ Disorders, Beijing 100081, Peoples R China

Recommended Citation:
Gan, YH,Shen, YH,Utama, B,et al. Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,340(1):29-34.
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