IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科
学科主题临床医学
BAP31 is frequently overexpressed in patients with primary colorectal cancer and correlates with better prognosis
Dong LingYi; Jiang KeWei; Zhang YanBin; Zhang Hui; Zhuo HongQing; Cui ZhiRong; Ye YingJiang; Wang Shan
关键词Bap31 Colorectal Cancer Immunohistochemistry Tissue Microarray Prognostic Marker
刊名CHINESE SCIENCE BULLETIN
2011-08-01
DOI10.1007/s11434-011-4610-0
56期:23页:2444-2449
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ENDOPLASMIC-RETICULUM ; CYTOCHROME-C ; CALRETICULIN EXPOSURE ; INDUCED APOPTOSIS ; CELL-DEATH ; MEMBRANE ; ASSOCIATION ; RELEASE ; MITOCHONDRIA ; STATISTICS
英文摘要

We previously showed that B cell receptor associated protein 31(BAP31) was significantly upregulated in colorectal cancer compared with normal mucosa epithelia. However, its expression pattern and pathological role in colorectal cancer are not clearly understood. In this study, we investigated whether the expression of BAP31 was associated with the clinicopathological parameters of colorectal cancer. The expression pattern of BAP31 was detected by immunohistochemistry on a tissue microarray in both primary tumor and paired distant normal mucosa samples from 120 consecutive colorectal cancer patients. Furthermore, BAP31 protein expression was also determined in twenty colorectal adenomas and eight liver metastasis samples. There was positive expression of BAP31 in 64.17% of primary tumors and 6.67% in distant normal mucosa (P=0.000). Negative expression of BAP31 was correlated with distant metastasis (P=0.036) and lower tumor differentiation grade (P=0.001). Patients with BAP31-negative expression showed significantly lower overall survival rate (P=0.003) compared to patients with BAP31-positive expression. Our results demonstrate that BAP31 may serve as a candidate prognostic marker in colorectal cancer and negative BAP31 expression may lead to more aggressive invasion of colorectal cancer.

语种英语
WOS记录号WOS:000292928700007
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50320
专题北京大学第二临床医学院_胃肠外科
作者单位Peking Univ, Peoples Hosp, Surg Oncol Lab, Dept Surg Gastroenterol, Beijing 100044, Peoples R China
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Dong LingYi,Jiang KeWei,Zhang YanBin,et al. BAP31 is frequently overexpressed in patients with primary colorectal cancer and correlates with better prognosis[J]. CHINESE SCIENCE BULLETIN,2011,56(23):2444-2449.
APA Dong LingYi.,Jiang KeWei.,Zhang YanBin.,Zhang Hui.,Zhuo HongQing.,...&Wang Shan.(2011).BAP31 is frequently overexpressed in patients with primary colorectal cancer and correlates with better prognosis.CHINESE SCIENCE BULLETIN,56(23),2444-2449.
MLA Dong LingYi,et al."BAP31 is frequently overexpressed in patients with primary colorectal cancer and correlates with better prognosis".CHINESE SCIENCE BULLETIN 56.23(2011):2444-2449.
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