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Modulation of interhemispheric activation balance in motor-related areas of stroke patients with motor recovery: Systematic review and meta-analysis of fMRI studies
McClure, Morgan A.1; Tang, Qing1; Li, Guangming2; Liu, Tao3; Wang, Anguo4; Feng, Shenggang5; Liao, Xiang1; Jin, Yu1; Guo, Zhiwei1; He, Bin1; Xing, Guoqiang6; Mu, Qiwen1,7
关键词Interhemispheric Activation Balance Laterality Index Stroke Motor Recovery Fmri Sensorimotor Cortex Premotor Cortex Supplementary Motor Area Cerebellum
刊名NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
2015-10-01
DOI10.1016/j.neubiorev.2015.09.003
57页:392-400
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
资助者National Natural Science Foundation of China (NSFC) ; State Administration of Foreign Experts Affairs, the P.R. of China ; Science &amp ; Technology Department of Sichuan Province ; Scientific Research Project of Sichuan Health Department ; National Natural Science Foundation of China (NSFC) ; State Administration of Foreign Experts Affairs, the P.R. of China ; Science &amp ; Technology Department of Sichuan Province ; Scientific Research Project of Sichuan Health Department
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]INDUCED MOVEMENT THERAPY ; TRANSCRANIAL MAGNETIC STIMULATION ; INDUCED CORTICAL REORGANIZATION ; RANDOMIZED CONTROLLED-TRIAL ; UPPER-LIMB RECOVERY ; LONGITUDINAL FMRI ; VIRTUAL-REALITY ; PREMOTOR CORTEX ; HAND FUNCTION ; NEURAL REORGANIZATION
英文摘要

Background: Functional magnetic resonance imaging (fMRI) studies suggest that stroke-induced motor deficits are associated with an interhemispheric imbalance of motor activation. This meta-analysis aims to determine the changes of interhemispheric activation balance (IHAB) in motor-related cortices along with post-stroke motor recovery.

Methods: We searched PubMed for fMRI studies that investigated IHAB in stroke patients with motor recovery. Laterality indexes (LIs, (ipsilesional activation - contralesional activation)/(ipsilesional activation + contralesional activation)) before and after motor improvement were extracted as the outcome measures of IHAB. Data were synthesized by calculating standardized mean difference (SMD, Hedges′ adjusted g) with 95% confidence intervals (Cl).

Results: After the rejection of 459 studies, 22 trials fulfilled the inclusion criteria and were included in the systematic review and meta-analysis. The Lis of sensorimotor cortex (SMC, 22 trials, 195 subjects), premotor cortex (PMC, 12 trials, 93 subjects), supplementary motor area (SMA, 12 trials, 92 subjects), and cerebellum (CB, 4 trials, 31 subjects) were assessed. Studies sampling from stroke patients with motor improvement showed positive changes of LI in SMC (SMD, 0.71; 95% Cl, 0.41-1.01; P<0.00001) and PMC (SMD, 0.68; 95% Cl, 0.36-1.00; P<0.0001), but not in SMA (SMD, 0.07; 95% Cl, -0.62 to 0.75; P=0.85) and CB (SMD, -0.17; 95% Cl, -1.52 to 1.19, P=0.81). Studies involving stroke patients with poor motor recovery showed non-significant changes in all of the four motor-related cortices (P>0.05).

Conclusions: This meta-analysis suggests that along with good motor recovery of stroke patients, the IHAB is up-regulated in SMC and PMC, but not significantly changed in SMA and CB. Because of the limited data, further studies are needed to verify the findings. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号81271559 ; 20155100056 ; 12JC0565 ; 110616
资助者National Natural Science Foundation of China (NSFC) ; State Administration of Foreign Experts Affairs, the P.R. of China ; Science &amp ; Technology Department of Sichuan Province ; Scientific Research Project of Sichuan Health Department ; National Natural Science Foundation of China (NSFC) ; State Administration of Foreign Experts Affairs, the P.R. of China ; Science &amp ; Technology Department of Sichuan Province ; Scientific Research Project of Sichuan Health Department
WOS记录号WOS:000364271200029
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50323
专题北京大学第三临床医学院
作者单位1.North Sichuan Med Univ, Nanchong Cent Hosp, Dept Urol Surg, Nanchong 637000, Sichuan, Peoples R China
2.North Sichuan Med Univ, Nanchong Cent Hosp, Dept Radiol & Imaging, Inst Rehabil & Dev Brain Funct, Nanchong 637000, Sichuan, Peoples R China
3.North Sichuan Med Univ, Nanchong Cent Hosp, Dept Oncol, Nanchong 637000, Sichuan, Peoples R China
4.North Sichuan Med Univ, Nanchong Cent Hosp, Dept Cardiol, Nanchong 637000, Sichuan, Peoples R China
5.North Sichuan Med Univ, Nanchong Cent Hosp, Dept Nephrol, Nanchong 637000, Sichuan, Peoples R China
6.Johns Hopkins Univ, MCC, Lotus Biotech Com LLC, Rockville, MD 20850 USA
7.Peking Univ, Hosp 3, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714
McClure, Morgan A.,Tang, Qing,Li, Guangming,et al. Modulation of interhemispheric activation balance in motor-related areas of stroke patients with motor recovery: Systematic review and meta-analysis of fMRI studies[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2015,57:392-400.
APA McClure, Morgan A..,Tang, Qing.,Li, Guangming.,Liu, Tao.,Wang, Anguo.,...&Mu, Qiwen.(2015).Modulation of interhemispheric activation balance in motor-related areas of stroke patients with motor recovery: Systematic review and meta-analysis of fMRI studies.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,57,392-400.
MLA McClure, Morgan A.,et al."Modulation of interhemispheric activation balance in motor-related areas of stroke patients with motor recovery: Systematic review and meta-analysis of fMRI studies".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 57(2015):392-400.
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