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Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys
Chen, Su-Qing1; Zhai, Hai-Feng1; Cui, Yan-Ying1; Shi, Jie1; Le Foll, Bernard1; Lu, Lin1
关键词Cocaine Withdrawal Drug Challenge Cross-sensitization Recurrence Monkeys
刊名ACTA PHARMACOLOGICA SINICA
2007-04-01
DOI10.1111/j.1745-7254.2007.00526.x
28期:4页:473-483
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CONDITIONED PLACE PREFERENCE ; STRESS-INDUCED REINSTATEMENT ; COCAINE-SEEKING BEHAVIOR ; LONG-TERM SENSITIZATION ; IN-VIVO MICRODIALYSIS ; OPIATE WITHDRAWAL ; OPIOID WITHDRAWAL ; LOCUS-COERULEUS ; DEPENDENT RATS ; NORADRENERGIC NEURONS
英文摘要

Aim: Clonidine is an alpha(2) adrenoceptor agonist that is frequently used to reduce withdrawal symptoms during opioid detoxification in humans. The long-term effects of clonidine on withdrawal symptoms and its effects on subsequent drug exposure have not been thoroughly documented. The aim of the study was to determine if clonidine administered during morphine withdrawal in rhesus monkeys produces long-lasting effects on withdrawal symptoms and alters the effects of subsequently taken drugs of abuse. Methods: Adult male rhesus monkeys were treated with increasing doses of morphine for 90 d to induce opiate (narcotic) dependence. The immediate and long-lasting effects of 1 week′s administration of clonidine were measured via the recording of morphine withdrawal signs and the subsequent effects of challenge injections of morphine or cocaine. Results: Monkeys chronically treated with morphine displayed withdrawal signs that lasted 2 weeks after cessation of morphine administration and displayed sensitized responses to subsequent morphine and cocaine injections. Clonidine significantly reduced certain morphine withdrawal signs and overall withdrawal score, but these effects did not persist upon cessation of clonidine treatment. Sensitization to the effects of morphine and cocaine were significantly reduced in monkeys previously treated with clonidine. Conclusion: Our results suggest that in addition to its short-term alleviating effect on morphine withdrawal signs, clonidine may reduce subsequent effects of drugs of abuse after prolonged abstinence.

语种英语
WOS记录号WOS:000245224700002
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50325
专题中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Dept Clin Pharmacol, Beijing 100083, Peoples R China
3.NIDA, Behav Neurosci Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA
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Chen, Su-Qing,Zhai, Hai-Feng,Cui, Yan-Ying,et al. Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys[J]. ACTA PHARMACOLOGICA SINICA,2007,28(4):473-483.
APA Chen, Su-Qing,Zhai, Hai-Feng,Cui, Yan-Ying,Shi, Jie,Le Foll, Bernard,&Lu, Lin.(2007).Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys.ACTA PHARMACOLOGICA SINICA,28(4),473-483.
MLA Chen, Su-Qing,et al."Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys".ACTA PHARMACOLOGICA SINICA 28.4(2007):473-483.
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