IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Human endothelial senescence induced by IL-1 alpha in vitro
Yao, AY1; Zhou, JJ1; Liu, YB1; Feng, MF1; Zhou, RL1
关键词Il-1 Alpha Endothelial Cell Senescence Ros Antioxidant Systems
刊名PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
2004-03-01
14期:3页:218-222
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Multidisciplinary ; Multidisciplinary Sciences
研究领域[WOS]Materials Science ; Science & Technology - Other Topics
关键词[WOS]AGE-DEPENDENT CHANGES ; ANTIOXIDANT ENZYMES ; DIETARY RESTRICTION ; WISTAR RATS ; INTERLEUKIN-1 ; CELLS ; EXPRESSION ; ARREST ; LIVER
英文摘要

Interleukin 1 (IL-1) is an important proinflammatory cytokine that causes pleiotropic effects. Vascular endothelial cells stimulated by IL-1alpha can lead to the inflammatory response. Reactive oxygen species (ROS) are also generated at the site of inflammation and serve as an important factor against foreign invader. Here we report that long-term stimulation of human vein endothelial cells with IL-1alpha can accelerate their senescence associated with beta-galactosidase activity. The flow cytometric analyses showed that most of the induced cells entered GO-G, phase. DNA damage was more severe in senescent cells by comet assay. The induced cells by IL-1alpha had higher levels of ROS and malonyldialdehyde (MDA), lower activity of antioxidant enzymes and lower capacity of total antioxidant systems than control, which led to cell damage and cell degeneration, that is to say, which contributed to cellular senescence. Our results gave a direct proof to a new hypothesis-"the inflammation hypothesis of aging" on cellular level, and also provided a basis for the study on anti-aging and aging-related diseases.

语种英语
WOS记录号WOS:000220878700004
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50327
专题北京大学基础医学院
作者单位1.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100080, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol & Med Genet, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yao, AY,Zhou, JJ,Liu, YB,et al. Human endothelial senescence induced by IL-1 alpha in vitro[J]. PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,2004,14(3):218-222.
APA Yao, AY,Zhou, JJ,Liu, YB,Feng, MF,&Zhou, RL.(2004).Human endothelial senescence induced by IL-1 alpha in vitro.PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,14(3),218-222.
MLA Yao, AY,et al."Human endothelial senescence induced by IL-1 alpha in vitro".PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL 14.3(2004):218-222.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yao, AY]的文章
[Zhou, JJ]的文章
[Liu, YB]的文章
百度学术
百度学术中相似的文章
[Yao, AY]的文章
[Zhou, JJ]的文章
[Liu, YB]的文章
必应学术
必应学术中相似的文章
[Yao, AY]的文章
[Zhou, JJ]的文章
[Liu, YB]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。