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学科主题: 基础医学
题名:
Human endothelial senescence induced by IL-1 alpha in vitro
作者: Yao, AY1; Zhou, JJ1; Liu, YB1; Feng, MF1; Zhou, RL1
关键词: IL-1 alpha ; endothelial cell ; senescence ; ROS ; antioxidant systems
刊名: PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
发表日期: 2004-03-01
卷: 14, 期:3, 页:218-222
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Multidisciplinary ; Multidisciplinary Sciences
研究领域[WOS]: Materials Science ; Science & Technology - Other Topics
关键词[WOS]: AGE-DEPENDENT CHANGES ; ANTIOXIDANT ENZYMES ; DIETARY RESTRICTION ; WISTAR RATS ; INTERLEUKIN-1 ; CELLS ; EXPRESSION ; ARREST ; LIVER
英文摘要:

Interleukin 1 (IL-1) is an important proinflammatory cytokine that causes pleiotropic effects. Vascular endothelial cells stimulated by IL-1alpha can lead to the inflammatory response. Reactive oxygen species (ROS) are also generated at the site of inflammation and serve as an important factor against foreign invader. Here we report that long-term stimulation of human vein endothelial cells with IL-1alpha can accelerate their senescence associated with beta-galactosidase activity. The flow cytometric analyses showed that most of the induced cells entered GO-G, phase. DNA damage was more severe in senescent cells by comet assay. The induced cells by IL-1alpha had higher levels of ROS and malonyldialdehyde (MDA), lower activity of antioxidant enzymes and lower capacity of total antioxidant systems than control, which led to cell damage and cell degeneration, that is to say, which contributed to cellular senescence. Our results gave a direct proof to a new hypothesis-"the inflammation hypothesis of aging" on cellular level, and also provided a basis for the study on anti-aging and aging-related diseases.

语种: 英语
WOS记录号: WOS:000220878700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50327
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100080, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol & Med Genet, Beijing 100083, Peoples R China

Recommended Citation:
Yao, AY,Zhou, JJ,Liu, YB,et al. Human endothelial senescence induced by IL-1 alpha in vitro[J]. PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,2004,14(3):218-222.
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