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Protocatechuic Acid Inhibits Rat Pheochromocytoma Cell Damage Induced by a Dopaminergic Neurotoxin
Zhang, Hong-Ning1,2; An, Chun-Na1,2; Xu, Man3; Guo, De-An3; Li, Min1; Pu, Xiao-Ping1,2
关键词Protocatechuic Acid Neuroprotection Rat Pheochromocytoma Cell 1-methyl-4-phenylpyridinium Ion Alpha-synuclein
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2009-11-01
32期:11页:1866-1869
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PARKINSONS-DISEASE ; ALPHA-SYNUCLEIN ; PC12 CELLS ; BRAIN ; APOPTOSIS ; ANALOGS
英文摘要

Parkinson′s disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (SN) with the presence of alpha-synuclein inclusions termed Lewy bodies. The aggregation of alpha-synuclein into oligomeric species affects neuronal viability, having a causal role in the development of PD. The neuroprotective effects of protocatechuic acid (PAc) have been reported. However. the effects of PAc on tyrosine hydroxylase (TH) and alpha-synuclein in rat pheochromocytoma (PC12) cells treated with 1-methyl-4-phenylpyridinium ion (MPP+) remains unclear. In this study, we demonstrated that PAc inhibited the cytotoxicity, apoptotic morphology, reduction of TH expression and abnormal oligomeration of alpha-synuclein in PC12 cells treated with MPP+. Taken together, our results indicate that the neuroprotective effects of PAc on PC12 cells treated with MPP+ is related to the inhibition of the oligomerization of alpha-synuclein.

语种英语
WOS记录号WOS:000271252900010
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50329
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
3.Peking Univ, Dept Nat Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Hong-Ning,An, Chun-Na,Xu, Man,et al. Protocatechuic Acid Inhibits Rat Pheochromocytoma Cell Damage Induced by a Dopaminergic Neurotoxin[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2009,32(11):1866-1869.
APA Zhang, Hong-Ning,An, Chun-Na,Xu, Man,Guo, De-An,Li, Min,&Pu, Xiao-Ping.(2009).Protocatechuic Acid Inhibits Rat Pheochromocytoma Cell Damage Induced by a Dopaminergic Neurotoxin.BIOLOGICAL & PHARMACEUTICAL BULLETIN,32(11),1866-1869.
MLA Zhang, Hong-Ning,et al."Protocatechuic Acid Inhibits Rat Pheochromocytoma Cell Damage Induced by a Dopaminergic Neurotoxin".BIOLOGICAL & PHARMACEUTICAL BULLETIN 32.11(2009):1866-1869.
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