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学科主题: 临床医学
题名:
Long-term Tumor-free Survival With Untreated Primary Diffuse Large B-cell Lymphoma of the Tonsil A Report of 9 Cases
作者: Zhang, Xiaojing1; Zheng, Yuanyuan1; Xie, Jianlan1; Zhu, Jun2; Song, Yuqin2; Teng, Xiaojing1; Liu, Wei1; Ding, Yi3; Huang, Yuhua4; Zhou, Xiaoge1
关键词: tonsil ; diffuse large B-cell lymphoma ; untreated cases ; long-term tumor-free survival ; clinicopathologic analysis
刊名: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
发表日期: 2015-11-01
DOI: 10.1097/PAS.0000000000000541
卷: 39, 期:11, 页:1493-1501
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology ; Surgery
研究领域[WOS]: Pathology ; Surgery
关键词[WOS]: HEALTH-ORGANIZATION CLASSIFICATION ; NON-HODGKINS-LYMPHOMA ; WALDEYERS RING ; ELDERLY-PATIENTS ; ONCOLOGY-GROUP ; YOUNG-ADULTS ; CHILDREN ; CHEMOTHERAPY ; CHOP ; RADIOTHERAPY
英文摘要:

In some cases, long-term tumor-free survival might be possible for untreated primary diffuse large B-cell lymphoma (DLBCL) of the tonsil. Here, we report of 9 untreated patients who had primary tonsil DLBCL with long-term tumor-free survival. All these patients were children or young adults (4 male and 5 female individuals; ages: 6 to 38 y, median age: 25 y) with clinically evident swollen tonsils or papillary neoplasms. Tonsillectomy and biopsies indicated partial structural destruction of the tonsils with diffuse infiltration of large lymphoid cells. The large cells expressed CD20 with a Ki-67 proliferative index >50%. All samples were negative for CD5, Epstein-Barr virus-encoded RNA, and t(14;18) translocation. Except for cases 2 and 4, all samples showed monoclonal immunoglobulin gene rearrangements. Although chemotherapy and radiotherapy had not been administered after tonsillectomy (for various reasons), periodic imaging and clinical evaluation showed that none of the 9 patients developed or died of lymphoma (median follow-up: 40 mo). In conclusion, primary tonsil DLBCL does not always behave in a malignant manner, and some patients can achieve long-term tumor-free survival without chemotherapy or radiotherapy. On the basis of this case series, we concluded that close follow-up and observation might be possible for pediatric and young-adult patients who have undergone complete tonsillectomy for primary tonsil DLBCL with the following features: short disease course, morphologically early lesions, negativity for Epstein-Barr virus-encoded RNA and t(14;18) translocation, and no involvement of any other sites, after careful clinical evaluation.

语种: 英语
所属项目编号: 81272633
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000363375900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50331
Appears in Collections:北京大学临床肿瘤学院_淋巴肿瘤内科_期刊论文

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作者单位: 1.Capital Med Univ, Dept Pathol, Beijing Friendship Hosp, Lymphoma Diagnost Ctr,Beijing Inst Clin Med, Beijing 100050, Peoples R China
2.Peking Univ, Beijing Canc Hosp, Dept Lymphoma, Beijing 100871, Peoples R China
3.Xiamen Univ, Dept Pathol, Affiliated Hosp 1, Xiamen, Peoples R China
4.Shenzhen Second Peoples Hosp, Dept Pathol, Shenzhen, Peoples R China

Recommended Citation:
Zhang, Xiaojing,Zheng, Yuanyuan,Xie, Jianlan,et al. Long-term Tumor-free Survival With Untreated Primary Diffuse Large B-cell Lymphoma of the Tonsil A Report of 9 Cases[J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY,2015,39(11):1493-1501.
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