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Increased hepatic peroxisome proliferator-activated receptor coactivator-1 alpha expression precedes the development of insulin resistance in offspring of rats from severe hyperglycemic mothers
Ma Jing-mei1; Zeng Chan-juan2; Zhang Li1; Shou Chong1; Yang Hui-xia1
关键词Prenatal Programming Peroxisome Proliferator-activated Receptor Coactivator-1 Alpha Phosphoenolpyruvate Carboxykinase Insulin Resistance
刊名CHINESE MEDICAL JOURNAL
2012-04-05
DOI10.3760/cma.j.issn.0366-6999.2012.07.007
125期:7页:1224-1229
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]INTRAUTERINE GROWTH-RETARDATION ; PREGNANT RAT ; DISEASE ; METABOLISM ; EXPOSURE ; ORIGINS ; HEALTH ; CHINA ; WOMEN ; PGC-1
英文摘要

Background Prenatal hyperglycaemia may increase metabolic syndrome susceptibility of the offspring. An underlying component of the development of these morbidities is hepatic gluconeogenic molecular dysfunction. We hypothesized that maternal hyperglycaemia will influence her offsprings hepatic peroxisome proliferator-activated receptor coactivator-1 alpha (PGC-1 alpha) expression, a key regulator of glucose production in hepatocytes.

Method We established maternal hyperglycaemia by streptozotocin injection to induce the maternal hyperglycaemic Wistar rat model. Offspring from the severe hyperglycemia group (SDO) and control group (CO) were monitored until 180 days after birth. Blood pressure, lipid metabolism indicators and insulin resistance (IR) were measured. Hepatic PGC-1 alpha expression was analyzed by reverse transcription polymerase chain reaction and Western blotting. mRNA expression of two key enzymes in gluconeogenesis, glucose-6-phospha-tase (G-6-Pase) and phosphoenolpyruvate carboxykinase (PEPCK), were analyzed and compared.

Results In the SDO group, PGC-1 alpha expression at protein and mRNA levels were increased, so were expression of G-6-Pase and PEPCK (P <0.05). The above effects were seen prior to the onset of IR.

Conclusion The hepatic gluconeogenic molecular dysfunction may contribute to the metabolic morbidities experienced by this population. Chin Med J 2012;125(7):1224-1229

语种英语
WOS记录号WOS:000302882600007
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50341
专题北京大学第一临床医学院
北京大学第一临床医学院_妇产科
作者单位1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
2.Int Peace Matern & Child Hlth Hosp, Dept Obstet & Gynecol, Shanghai 200030, Peoples R China
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Ma Jing-mei,Zeng Chan-juan,Zhang Li,et al. Increased hepatic peroxisome proliferator-activated receptor coactivator-1 alpha expression precedes the development of insulin resistance in offspring of rats from severe hyperglycemic mothers[J]. CHINESE MEDICAL JOURNAL,2012,125(7):1224-1229.
APA Ma Jing-mei,Zeng Chan-juan,Zhang Li,Shou Chong,&Yang Hui-xia.(2012).Increased hepatic peroxisome proliferator-activated receptor coactivator-1 alpha expression precedes the development of insulin resistance in offspring of rats from severe hyperglycemic mothers.CHINESE MEDICAL JOURNAL,125(7),1224-1229.
MLA Ma Jing-mei,et al."Increased hepatic peroxisome proliferator-activated receptor coactivator-1 alpha expression precedes the development of insulin resistance in offspring of rats from severe hyperglycemic mothers".CHINESE MEDICAL JOURNAL 125.7(2012):1224-1229.
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