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学科主题: 临床医学
题名:
Increased hepatic peroxisome proliferator-activated receptor coactivator-1 alpha expression precedes the development of insulin resistance in offspring of rats from severe hyperglycemic mothers
作者: Ma Jing-mei1; Zeng Chan-juan2; Zhang Li1; Shou Chong1; Yang Hui-xia1
关键词: prenatal programming ; peroxisome proliferator-activated receptor coactivator-1 alpha ; phosphoenolpyruvate carboxykinase ; insulin resistance
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-04-05
DOI: 10.3760/cma.j.issn.0366-6999.2012.07.007
卷: 125, 期:7, 页:1224-1229
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: INTRAUTERINE GROWTH-RETARDATION ; PREGNANT RAT ; DISEASE ; METABOLISM ; EXPOSURE ; ORIGINS ; HEALTH ; CHINA ; WOMEN ; PGC-1
英文摘要:

Background Prenatal hyperglycaemia may increase metabolic syndrome susceptibility of the offspring. An underlying component of the development of these morbidities is hepatic gluconeogenic molecular dysfunction. We hypothesized that maternal hyperglycaemia will influence her offsprings hepatic peroxisome proliferator-activated receptor coactivator-1 alpha (PGC-1 alpha) expression, a key regulator of glucose production in hepatocytes.

Method We established maternal hyperglycaemia by streptozotocin injection to induce the maternal hyperglycaemic Wistar rat model. Offspring from the severe hyperglycemia group (SDO) and control group (CO) were monitored until 180 days after birth. Blood pressure, lipid metabolism indicators and insulin resistance (IR) were measured. Hepatic PGC-1 alpha expression was analyzed by reverse transcription polymerase chain reaction and Western blotting. mRNA expression of two key enzymes in gluconeogenesis, glucose-6-phospha-tase (G-6-Pase) and phosphoenolpyruvate carboxykinase (PEPCK), were analyzed and compared.

Results In the SDO group, PGC-1 alpha expression at protein and mRNA levels were increased, so were expression of G-6-Pase and PEPCK (P <0.05). The above effects were seen prior to the onset of IR.

Conclusion The hepatic gluconeogenic molecular dysfunction may contribute to the metabolic morbidities experienced by this population. Chin Med J 2012;125(7):1224-1229

语种: 英语
所属项目编号: 30973212
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000302882600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50341
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
2.Int Peace Matern & Child Hlth Hosp, Dept Obstet & Gynecol, Shanghai 200030, Peoples R China

Recommended Citation:
Ma Jing-mei,Zeng Chan-juan,Zhang Li,et al. Increased hepatic peroxisome proliferator-activated receptor coactivator-1 alpha expression precedes the development of insulin resistance in offspring of rats from severe hyperglycemic mothers[J]. CHINESE MEDICAL JOURNAL,2012,125(7):1224-1229.
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