IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科
学科主题临床医学
Tissue inhibitor of metalloproteinases-3 transfer suppresses malignant behaviors of colorectal cancer cells
Lin, H.1,2; Zhang, Y.3; Wang, H.4; Xu, D.4; Meng, X.4; Shao, Y.4; Lin, C.4; Ye, Y.1; Qian, H.4; Wang, S.1
关键词Timp3 Colon Cancer Metastasis Apoptosis
刊名CANCER GENE THERAPY
2012-12-01
DOI10.1038/cgt.2012.70
19期:12页:845-851
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Medicine, Research & Experimental
资助者National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program)
研究领域[WOS]Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Research & Experimental Medicine
关键词[WOS]IN-VITRO ; PROGNOSTIC-SIGNIFICANCE ; TIMP-3 ; EXPRESSION ; CARCINOMA ; INVASION ; DEATH ; ANGIOGENESIS ; METASTASIS ; MIGRATION
英文摘要

Colorectal carcinoma is one of the most frequent cancer diseases. For patients with this type of cancer, liver metastases are the main cause of death. Therefore, new therapeutic approaches are urgently needed to improve the outcomes. We found that both mRNA and protein levels of tissue inhibitor of metalloproteinase-3 (TIMP3) were decreased significantly in colorectal cancer tissue when compared with normal mucosa, suggesting that decrease of TIMP3 expression was correlated with malignant behavior of colorectal cancer. We evaluated the power of TIMP3, a new potent multiple functional molecule, as a biotheropeutic tool to treat cancer. Adenovirus-mediated TIMP3 transduction in CT26 colon cancer model demonstrated multiple effects to arrest cancer cell growth and induced massive apoptosis. Also, adenovirally transferred TIMP3 reduced adhesion, migration and invasion behaviors of CT26 cells in vitro. In vivo data showed that TIMP3 suppressed in vivo tumor growth and that liver metastasis was significantly reduced by TIMP3 transduction. This is the first systematic preclinical study to show that TIMP3 may be a potential molecular tool for colon cancer biological therapy.

语种英语
所属项目编号2009CB521807
资助者National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program)
WOS记录号WOS:000311164100006
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50342
Collection北京大学第二临床医学院_胃肠外科
作者单位1.Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China
2.Tsinghua Univ, Hosp 1, Dept Gen Surg, Beijing 100084, Peoples R China
3.Capital Univ Med Sci, Beijing Obstet & Gynecol Hosp, Minimal Invas Ctr, Dept Gynecol, Beijing, Peoples R China
4.Chinese Acad Med Sci, Canc Inst Hosp, State Key Lab Mol Oncol, Beijing 100730, Peoples R China
Recommended Citation
GB/T 7714
Lin, H.,Zhang, Y.,Wang, H.,et al. Tissue inhibitor of metalloproteinases-3 transfer suppresses malignant behaviors of colorectal cancer cells[J]. CANCER GENE THERAPY,2012,19(12):845-851.
APA Lin, H..,Zhang, Y..,Wang, H..,Xu, D..,Meng, X..,...&Wang, S..(2012).Tissue inhibitor of metalloproteinases-3 transfer suppresses malignant behaviors of colorectal cancer cells.CANCER GENE THERAPY,19(12),845-851.
MLA Lin, H.,et al."Tissue inhibitor of metalloproteinases-3 transfer suppresses malignant behaviors of colorectal cancer cells".CANCER GENE THERAPY 19.12(2012):845-851.
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