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学科主题: 临床医学
题名:
Angiotensin-(1-7) regulates Angiotensin II-induced VCAM-1 expression on vascular endothelial cells
作者: Zhang, Feng1,2; Ren, Jingyi1; Chan, Kenneth2; Chen, Hong1
关键词: Angiotensin-(1-7) ; Angiotensin II ; Angiotensin-converting enzyme 2 ; VCAM-1 expression
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2013-01-11
DOI: 10.1016/j.bbrc.2012.11.098
卷: 430, 期:2, 页:642-646
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: NF-KAPPA-B ; ADHESION MOLECULE-1 ; DEFICIENT MICE ; ATHEROSCLEROSIS ; ACTIVATION ; RECEPTOR ; TRANSLOCATION ; DYSFUNCTION ; INHIBITION ; SYSTEM
英文摘要:

Angiotensin II (Ang II) and Angiotensin-(1-7) (Ang-(1-7)) are key effector peptides in the renin-angiotensin system. Increased circulatory Ang II level is associated with the development of hypertension and atherosclerosis, whereas Ang-(1-7) is a counter-regulatory mediator of Ang II which appears to be protective against cardiovascular disease. However, whether Ang-(1-7) regulates the action of Ang II on vascular endothelial cells (EC) remains unclear. We investigated the effects of Ang II and Ang-(1-7) in the context of atherogenesis, specifically endothelial cell VCAM-1 expression that is implicated in early plaque formation. The results show that Ang II increased VCAM-1 mRNA expression and protein displayed on EC surface, while Ang-(1-7) alone exerted no effects. However, Ang-(1-7) significantly suppressed Ang II-induced VCAM-1 expression. Ang-(1-7) also inhibited the Ang II-induced VCAM-1 promoter activity driven by transcription factor NF-KappaB. Furthermore, immunofluorescence assay and ELISA showed that Ang II facilitated the nuclear translocation of NF-kappaB in ECs, and this was attenuated by the presence of Ang-(1-7). The inhibitory effects of Ang-(1-7) on Ang II-induced VCAM-1 promoter activity and NF-kappaB nuclear translocation were all reversed by the competitive antagonist of Ang-(1-7) at the Mas receptor. Our results suggest that Ang-(1-7) mediates its affects on ECs through the Mas receptor, and negatively regulates Ang II-induced VCAM-1 expression by attenuating nuclear translocation of NF-kappaB. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: RDB2011-16
项目资助者: Peking University People&prime ; s Hospital
WOS记录号: WOS:000314257800034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50346
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100871, Peoples R China
2.Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, London, England

Recommended Citation:
Zhang, Feng,Ren, Jingyi,Chan, Kenneth,et al. Angiotensin-(1-7) regulates Angiotensin II-induced VCAM-1 expression on vascular endothelial cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,430(2):642-646.
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