|Genetic variants and the risk of gestational diabetes mellitus: a systematic review|
|Zhang, Cuilin1; Bao, Wei1; Rong, Ying2; Yang, Huixia3; Bowers, Katherine1; Yeung, Edwina1; Kiely, Michele1|
|关键词||Gestational Diabetes Mellitus Single Nucleotide Polymorphism Gene Genetic Factors|
|刊名||HUMAN REPRODUCTION UPDATE|
|WOS标题词||Science & Technology|
|类目[WOS]||Obstetrics & Gynecology ; Reproductive Biology|
|研究领域[WOS]||Obstetrics & Gynecology ; Reproductive Biology|
|关键词[WOS]||GENOME-WIDE ASSOCIATION ; BETA(3)-ADRENERGIC RECEPTOR GENE ; POLYCYSTIC-OVARY-SYNDROME ; INSULIN-SECRETION ; TCF7L2 GENE ; TRANSCRIPTION-FACTOR-7-LIKE-2 TCF7L2 ; TRP(64)ARG POLYMORPHISM ; MEXICAN-AMERICANS ; GREEK POPULATION ; GLUCOKINASE GENE|
Several studies have examined associations between genetic variants and the risk of gestational diabetes mellitus (GDM). However, inferences from these studies were often hindered by limited statistical power and conflicting results. We aimed to systematically review and quantitatively summarize the association of commonly studied single nucleotide polymorphisms (SNPs) with GDM risk and to identify important gaps that remain for consideration in future studies.
Genetic association studies of GDM published through 1 October 2012 were searched using the HuGE Navigator and PubMed databases. A SNP was included if the SNPGDM associations were assessed in three or more independent studies. Two reviewers independently evaluated the eligibility for inclusion and extracted the data. The allele-specific odds ratios (ORs) and 95 confidence intervals (CIs) were pooled using random effects models accounting for heterogeneity.
Overall, 29 eligible articles capturing associations of 12 SNPs from 10 genes were included for the systematic review. The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (30G/A, GCK), rs5219 (E23K, KCNJ11), rs7754840 (CDKAL1), rs4402960 (IGF2BP2), rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs1801278 (Gly972Arg, IRS1) were significantly associated with a higher risk of GDM. Among them, genetic variants in TCF7L2 showed the strongest association with GDM risk, with ORs (95 CIs) of 1.44 (1.291.60, P 0.001) per T allele of rs7903146 and 1.46 (1.151.84, P 0.002) per T allele of rs12255372.
In this systematic review, we found significant associations of GDM risk with nine SNPs in seven genes, most of which have been related to the regulation of insulin secretion.
|资助机构||Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health|
|作者单位||1.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Epidemiol Stat & Prevent Res, NIH, Rockville, MD 20852 USA|
2.Huazhong Univ Sci & Technol, Dept Nutr & Food Hyg, Hubei Key Lab Food Nutr & Safety, Sch Publ Hlth,Tongji Med Coll, Wuhan 430030, Peoples R China
3.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
|Zhang, Cuilin,Bao, Wei,Rong, Ying,et al. Genetic variants and the risk of gestational diabetes mellitus: a systematic review[J]. HUMAN REPRODUCTION UPDATE,2013,19(4):376-390.|
|APA||Zhang, Cuilin.,Bao, Wei.,Rong, Ying.,Yang, Huixia.,Bowers, Katherine.,...&Kiely, Michele.(2013).Genetic variants and the risk of gestational diabetes mellitus: a systematic review.HUMAN REPRODUCTION UPDATE,19(4),376-390.|
|MLA||Zhang, Cuilin,et al."Genetic variants and the risk of gestational diabetes mellitus: a systematic review".HUMAN REPRODUCTION UPDATE 19.4(2013):376-390.|