IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Genetic variants and the risk of gestational diabetes mellitus: a systematic review
Zhang, Cuilin1; Bao, Wei1; Rong, Ying2; Yang, Huixia3; Bowers, Katherine1; Yeung, Edwina1; Kiely, Michele1
关键词Gestational Diabetes Mellitus Single Nucleotide Polymorphism Gene Genetic Factors
刊名HUMAN REPRODUCTION UPDATE
2013-07-01
DOI10.1093/humupd/dmt013
19期:4页:376-390
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]GENOME-WIDE ASSOCIATION ; BETA(3)-ADRENERGIC RECEPTOR GENE ; POLYCYSTIC-OVARY-SYNDROME ; INSULIN-SECRETION ; TCF7L2 GENE ; TRANSCRIPTION-FACTOR-7-LIKE-2 TCF7L2 ; TRP(64)ARG POLYMORPHISM ; MEXICAN-AMERICANS ; GREEK POPULATION ; GLUCOKINASE GENE
英文摘要

Several studies have examined associations between genetic variants and the risk of gestational diabetes mellitus (GDM). However, inferences from these studies were often hindered by limited statistical power and conflicting results. We aimed to systematically review and quantitatively summarize the association of commonly studied single nucleotide polymorphisms (SNPs) with GDM risk and to identify important gaps that remain for consideration in future studies.

Genetic association studies of GDM published through 1 October 2012 were searched using the HuGE Navigator and PubMed databases. A SNP was included if the SNPGDM associations were assessed in three or more independent studies. Two reviewers independently evaluated the eligibility for inclusion and extracted the data. The allele-specific odds ratios (ORs) and 95 confidence intervals (CIs) were pooled using random effects models accounting for heterogeneity.

Overall, 29 eligible articles capturing associations of 12 SNPs from 10 genes were included for the systematic review. The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (30G/A, GCK), rs5219 (E23K, KCNJ11), rs7754840 (CDKAL1), rs4402960 (IGF2BP2), rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs1801278 (Gly972Arg, IRS1) were significantly associated with a higher risk of GDM. Among them, genetic variants in TCF7L2 showed the strongest association with GDM risk, with ORs (95 CIs) of 1.44 (1.291.60, P 0.001) per T allele of rs7903146 and 1.46 (1.151.84, P 0.002) per T allele of rs12255372.

In this systematic review, we found significant associations of GDM risk with nine SNPs in seven genes, most of which have been related to the regulation of insulin secretion.

语种英语
WOS记录号WOS:000320463500006
资助机构Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
引用统计
被引频次:80[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50347
专题北京大学第一临床医学院
北京大学第一临床医学院_妇产科
作者单位1.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Epidemiol Stat & Prevent Res, NIH, Rockville, MD 20852 USA
2.Huazhong Univ Sci & Technol, Dept Nutr & Food Hyg, Hubei Key Lab Food Nutr & Safety, Sch Publ Hlth,Tongji Med Coll, Wuhan 430030, Peoples R China
3.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Cuilin,Bao, Wei,Rong, Ying,et al. Genetic variants and the risk of gestational diabetes mellitus: a systematic review[J]. HUMAN REPRODUCTION UPDATE,2013,19(4):376-390.
APA Zhang, Cuilin.,Bao, Wei.,Rong, Ying.,Yang, Huixia.,Bowers, Katherine.,...&Kiely, Michele.(2013).Genetic variants and the risk of gestational diabetes mellitus: a systematic review.HUMAN REPRODUCTION UPDATE,19(4),376-390.
MLA Zhang, Cuilin,et al."Genetic variants and the risk of gestational diabetes mellitus: a systematic review".HUMAN REPRODUCTION UPDATE 19.4(2013):376-390.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Cuilin]的文章
[Bao, Wei]的文章
[Rong, Ying]的文章
百度学术
百度学术中相似的文章
[Zhang, Cuilin]的文章
[Bao, Wei]的文章
[Rong, Ying]的文章
必应学术
必应学术中相似的文章
[Zhang, Cuilin]的文章
[Bao, Wei]的文章
[Rong, Ying]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。