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学科主题: 口腔医学
题名:
Melanoma differentiation-associated gene-7/interleukin-24 as a potential prognostic biomarker and second primary malignancy indicator in head and neck squamous cell carcinoma patients
作者: Wang, Lin1; Feng, Zhien1; Wu, Huanhuan1; Zhang, Shuai1; Pu, Yinfei1; Bian, Huan1; Wang, Yixiang2; Guo, Chuanbin1
关键词: MDA-7/IL-24 ; Squamous cell carcinoma of the head and neck ; Second primary malignancy ; Biomarker ; Prognosis
刊名: TUMOR BIOLOGY
发表日期: 2014-11-01
DOI: 10.1007/s13277-014-2392-0
卷: 35, 期:11, 页:10977-10985
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ADENOVIRUS-MEDIATED MDA-7 ; PERK-DEPENDENT REGULATION ; CANCER CELLS ; GENE-EXPRESSION ; PROSTATE-CANCER ; LUNG-CANCER ; MDA-7/IL-24 ; GROWTH ; INHIBITION ; APOPTOSIS
英文摘要:

The significance of melanoma differentiation-associated gene-7/interleukin-24 (MDA-7/IL-24) expression in head and neck squamous cell carcinoma (HNSCC) remains unclear. This study was designed to investigate and evaluate the clinical significance of MDA-7/IL-24 expression in HNSCC by detecting expression by immunostaining in 131 HNSCC specimens. The function of MDA-7/IL-24 was investigated by real-time polymerase chain reaction (PCR) and Western blot in Ad5.mda-7-infected HNSCC cell lines. Our results showed that MDA-7/IL-24 was mainly expressed in the cytoplasm of HNSCC cells. MDA-7/IL-24 high patients presented with a favorable postoperative prognosis compared with MDA-7/IL-24 low patients, and high expression of MDA-7/IL-24 was significantly correlated with a lower incidence of second primary malignancies (SPMs) in the head and neck regions. In vitro assays showed that high expression of MDA-7/IL-24 could upregulate the expression of the epithelial terminal differentiation markers cytokeratin (KRT) 1, KRT4, KRT13, phosphorylated endoplasmic reticulum stress protein (p)-EIF2a, and the apoptosis-related protein cleaved caspase-3. It also downregulated the epithelial proliferative markers KRT5, KRT14, Integrin beta 4, and anti-apoptosis protein Bcl-2, which might be partially involved in the underlying mechanisms of Ad.mda-7-mediated HNSCC differentiation and apoptosis. Our results indicate that MDA-7/IL-24 can be a prognostic biomarker and an indicator of second primary malignancies (SPM) in HNSCC.

语种: 英语
所属项目编号: 2009AA045201 ; 2012AA041606 ; 201-4025-02 ; 2013 M530495
项目资助者: Peking University ; National High Technology Research and Development Program of China ; Special fund for Capital Medical Development ; China Postdoctoral Science Foundation
WOS记录号: WOS:000345413100044
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50355
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China

Recommended Citation:
Wang, Lin,Feng, Zhien,Wu, Huanhuan,et al. Melanoma differentiation-associated gene-7/interleukin-24 as a potential prognostic biomarker and second primary malignancy indicator in head and neck squamous cell carcinoma patients[J]. TUMOR BIOLOGY,2014,35(11):10977-10985.
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