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学科主题: 基础医学
题名:
Cytokines transduced bone marrow stromal cell lines promote immunohematopoietic reconstitution in mice after allogeneic bone marrow transplantation
作者: Li, AL1; Jiang, JY1; Zhang, QY1; Hao, J1; Xie, SS1
关键词: allogeneic bone marrow transplantation ; hematopoiesis ; immune reconstitution ; bone marrow stromal cell
刊名: IMMUNOLOGY LETTERS
发表日期: 2005-05-15
DOI: 10.1016/j.imlet.2004.11.018
卷: 98, 期:2, 页:216-224
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: SEVERE COMBINED IMMUNODEFICIENCY ; ACUTE MYELOGENOUS LEUKEMIA ; HEMATOPOIETIC STEM-CELLS ; HEMATOLOGIC MALIGNANCIES ; PROGENITOR CELLS ; LATE INFECTIONS ; KILLER-CELLS ; IN-VIVO ; INTERLEUKIN-2 ; INVITRO
英文摘要:

Impaired immune reconstitution following allogeneic T-cell depleted bone marrow transplantation (allo-TCD-BMT) is a major obstacle to its clinical application. Stromal cell line QXMSC1, established from bone marrow cells of BALB/c(H-2(d)), was transfected with murine IL-3 and/ or IL-2 gene, and injected into lethally irradiated C57BL/6(H2(b)) mice. We evaluated its effects on immunologic and hematopoietic reconstitution after allo-TCD-BMT. The results showed that QXMSC1-IL-3 + IL-2 could significantly increase the numbers of hematopoietic primitive progenitors (CFU-S), committed progenitors (CFU-GM, and BFU-E), and lymphocytes (CD8(+) cells, CD4(+) cells, and B cells). Similarly, immune functions of recipient mice were significantly enhanced in the QXMSC1-IL-3 + IL-2 group. In addition, QXNISC1-IL-3 or QXMSC1-IL-2 also exerted apparent effects on accelerating immune reconstitution, but these effects were far less than that of QXMSC1-IL-3 + IL-2. Our results demonstrated that stromal cell-mediated IL-3 and IL-2 gene therapy may be a potent approach in promoting immunologic and hematopoietic reconstitution after allo-TCD-BMT. (c) 2004 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000229253800008
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50356
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing, Peoples R China
2.Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN USA
3.Harvard Univ, Massachusetts Gen Hosp, Sch Med,Transplantat Biol Res Ctr, Bone Marrow Transplantat Sect, Boston, MA USA

Recommended Citation:
Li, AL,Jiang, JY,Zhang, QY,et al. Cytokines transduced bone marrow stromal cell lines promote immunohematopoietic reconstitution in mice after allogeneic bone marrow transplantation[J]. IMMUNOLOGY LETTERS,2005,98(2):216-224.
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