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学科主题: 基础医学
题名:
Cytoplasmic alpha-fetoprotein functions as a co-repressor in RA-RAR signaling to promote the growth of human hepatoma Bel 7402 cells
作者: Li, Mengsen1,2; Li, Hui1; Li, Chaoying1; Guo, Liyuan1; Liu, Han1; Zhou, Sheng2; Liu, Xinhua1; Chen, Zhuo1; Shi, Shuanglin3; Wei, Jiang1; McNutt, Michael A.4; Li, Gang1
关键词: Alpha-fetoprotein ; Hepatoma ; All trans retinoic acid ; Nuclear receptor ; Apoptosis
刊名: CANCER LETTERS
发表日期: 2009-11-28
DOI: 10.1016/j.canlet.2009.05.014
卷: 285, 期:2, 页:190-199
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: OPIOID RECEPTOR GENE ; 2ND PRIMARY TUMORS ; HEPATOCELLULAR-CARCINOMA ; BINDING-PROTEINS ; BREAST-CANCER ; HUMAN-LYMPHOCYTES ; GASTRIC CANCERS ; EXPRESSION ; ACID ; PROLIFERATION
英文摘要:

The role of AFP in the retinoic acid-RAR signaling pathway was investigated in human hepatoma Bel 7402 cells. The results showed that AFP and RAR-beta were co-localized and interacted in cytoplasm. AFP may inhibit translocation of RAR-beta into the nucleus via competitive binding to RAR-beta with ATRA, which was reversed by AFP-siRNA transfection. Our data suggest that the ATRA resistance of Bel 7402 cells is at least in part attributable to their high level of cytoplasmic AFP. Thus, by counteracting the effect of AFP, it may be possible to increase the sensitivity of tumor cells to ATRA. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30621002 ; 30671856 ; 30772536 ; 30660071 ; 30760090 ; 20070001735
项目资助者: National Natural Science Foundation of China ; Foundation of National Education Ministry for graduate
WOS记录号: WOS:000271693800011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50368
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Biochem & Mol Biol, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Hainan Med Coll, Key Lab Mol Biol, Haikou 571101, Peoples R China
3.Beihua Univ, Dept Biochem, Jilin 132013, Peoples R China
4.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Li, Mengsen,Li, Hui,Li, Chaoying,et al. Cytoplasmic alpha-fetoprotein functions as a co-repressor in RA-RAR signaling to promote the growth of human hepatoma Bel 7402 cells[J]. CANCER LETTERS,2009,285(2):190-199.
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