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学科主题基础医学
Cytoplasmic alpha-fetoprotein functions as a co-repressor in RA-RAR signaling to promote the growth of human hepatoma Bel 7402 cells
Li, Mengsen1,2; Li, Hui1; Li, Chaoying1; Guo, Liyuan1; Liu, Han1; Zhou, Sheng2; Liu, Xinhua1; Chen, Zhuo1; Shi, Shuanglin3; Wei, Jiang1; McNutt, Michael A.4; Li, Gang1
关键词Alpha-fetoprotein Hepatoma All trans retinoic acid Nuclear receptor Apoptosis
刊名CANCER LETTERS
2009-11-28
DOI10.1016/j.canlet.2009.05.014
285期:2页:190-199
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]OPIOID RECEPTOR GENE ; 2ND PRIMARY TUMORS ; HEPATOCELLULAR-CARCINOMA ; BINDING-PROTEINS ; BREAST-CANCER ; HUMAN-LYMPHOCYTES ; GASTRIC CANCERS ; EXPRESSION ; ACID ; PROLIFERATION
英文摘要

The role of AFP in the retinoic acid-RAR signaling pathway was investigated in human hepatoma Bel 7402 cells. The results showed that AFP and RAR-beta were co-localized and interacted in cytoplasm. AFP may inhibit translocation of RAR-beta into the nucleus via competitive binding to RAR-beta with ATRA, which was reversed by AFP-siRNA transfection. Our data suggest that the ATRA resistance of Bel 7402 cells is at least in part attributable to their high level of cytoplasmic AFP. Thus, by counteracting the effect of AFP, it may be possible to increase the sensitivity of tumor cells to ATRA. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000271693800011
项目编号30621002 ; 30671856 ; 30772536 ; 30660071 ; 30760090 ; 20070001735
资助机构National Natural Science Foundation of China ; Foundation of National Education Ministry for graduate
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50368
专题北京大学基础医学院_病理学系
北京大学基础医学院
北京大学口腔医学院_护理部
作者单位1.Peking Univ, Dept Biochem & Mol Biol, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Hainan Med Coll, Key Lab Mol Biol, Haikou 571101, Peoples R China
3.Beihua Univ, Dept Biochem, Jilin 132013, Peoples R China
4.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Li, Mengsen,Li, Hui,Li, Chaoying,et al. Cytoplasmic alpha-fetoprotein functions as a co-repressor in RA-RAR signaling to promote the growth of human hepatoma Bel 7402 cells[J]. CANCER LETTERS,2009,285(2):190-199.
APA Li, Mengsen.,Li, Hui.,Li, Chaoying.,Guo, Liyuan.,Liu, Han.,...&Li, Gang.(2009).Cytoplasmic alpha-fetoprotein functions as a co-repressor in RA-RAR signaling to promote the growth of human hepatoma Bel 7402 cells.CANCER LETTERS,285(2),190-199.
MLA Li, Mengsen,et al."Cytoplasmic alpha-fetoprotein functions as a co-repressor in RA-RAR signaling to promote the growth of human hepatoma Bel 7402 cells".CANCER LETTERS 285.2(2009):190-199.
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