|Hysteroscopy and directed biopsy in the diagnosis of endometrial carcinoma|
|Zhu Hong-lan; Liang Xu-dong; Wang Jian-liu; Cui Heng; Wei Li-hui|
|关键词||Hysteroscopy Endometrial Carcinoma Dilatation And Curettage Diagnosis Prognosis|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||FLUID HYSTEROSCOPY ; CERVICAL INVASION ; PERITONEAL WASHINGS ; CELL DISSEMINATION ; CANCER ; HYPERPLASIA ; CURETTAGE ; STAGE ; WOMEN ; DILATATION|
Background Diagnostic hysteroscopy and directed biopsy has been widely used to evaluate abnormal uterine bleeding. We aimed to explore the value of hysteroscopy and directed biopsy in the diagnosis of endometrial carcinoma.
Methods Two hundred and eighty-seven patients with endometrial carcinoma who were treated in Beijing University People′s Hospital, Beijing, China were distributed into 2 groups: Group A (90 patients) was examined using hysteroscopy and directed biopsy, and Group B (197 patients) was examined using fractional dilatation and curettage (D&C). The diagnostic veracity of the two methods, the rate of positive peritoneal cytology and the prognosis of the 2 groups were compared.
Results In Group A, 97.8% (88/90) of patients were diagnosed pathologically before surgery; the rate was 88.8% (175/197) for Group B. The difference between the 2 groups was statistically significant (P <0.05). The sensitivity, specificity, positive predictive value and negative predictive value for the two methods for detecting cervical involvement were 77.8%, 100%, 100% and 97.6% for Group A and 65.3%, 92.6%, 74.4% and 90.0% for Group B, respectively. The positive peritoneal cytology rate was 5.6% (5/90) in Group A and 6.09% (12/197) in Group B. The difference was not statistically significant (P >0.05). The 3-year and 5-year overall survival rates were 91.4% (33/36) and 82.4% (14/17) for Group A and 95.6% (87/91) and 86.7% (39/45) for Group B. There were no statistically significant differences between the two groups′ survival rates (P >0.05).
Conclusion Compared with fractional D&C, hysteroscopy and directed biopsy offered improved pathological diagnostic accuracy before surgery and discovered cervical involvement more precisely in endometrial carcinoma patients, but it did not increase the positive peritoneal cytology rate or affect the prognosis of these patients. Chin Med J 2010;123(24):3524-3528
|作者单位||Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100044, Peoples R China|
|Zhu Hong-lan,Liang Xu-dong,Wang Jian-liu,et al. Hysteroscopy and directed biopsy in the diagnosis of endometrial carcinoma[J]. CHINESE MEDICAL JOURNAL,2010,123(24):3524-3528.|
|APA||Zhu Hong-lan,Liang Xu-dong,Wang Jian-liu,Cui Heng,&Wei Li-hui.(2010).Hysteroscopy and directed biopsy in the diagnosis of endometrial carcinoma.CHINESE MEDICAL JOURNAL,123(24),3524-3528.|
|MLA||Zhu Hong-lan,et al."Hysteroscopy and directed biopsy in the diagnosis of endometrial carcinoma".CHINESE MEDICAL JOURNAL 123.24(2010):3524-3528.|