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Uric Acid Is Associated with Metabolic Syndrome in Children and Adults in a Community: The Bogalusa Heart Study
Sun, Dianjianyi1,2; Li, Shengxu2; Zhang, Xiaotao2; Fernandez, Camilo2; Chen, Wei2; Srinivasan, Sathanur R.2; Berenson, Gerald S.2
刊名PLOS ONE
2014-10-24
DOI10.1371/journal.pone.0089696
9期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Institute of Environmental Health Science ; National Institute on Aging ; American Heart Association ; National Institute of Environmental Health Science ; National Institute on Aging ; American Heart Association
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]BLOOD-PRESSURE ; CARDIOVASCULAR-DISEASE ; SCIENTIFIC STATEMENT ; CELL-PROLIFERATION ; INSULIN-RESISTANCE ; YOUNG ADULTHOOD ; SYNDROME-X ; RISK ; ADOLESCENTS ; CHILDHOOD
英文摘要

Background: Elevated serum uric acid (UA) is commonly found in subjects with metabolic syndrome (MetS). This study examined the association of UA with levels of individual MetS components and the degree of their clustering patterns in both children and adults.

Methods: The study sample consisted of 2614 children aged 4-18 years and 2447 adults aged 19-54 years. MetS components included body mass index (BMI), mean arterial pressure (MAP), triglycerides to high-density lipoprotein cholesterol ratio (TG/HDLC), and homeostasis model assessment of insulin resistance (HOMA). Observed/expected (O/E) ratio and intra-class correlation coefficient (ICC) were used as a measure of the degree of clustering of categorical and continuous MetS variables, respectively.

Results: UA was positively and significantly associated only with BMI in children but with all four components in adults. The odds ratio for MetS associated with 1 mg/dL increase of UA was 1.74 (p<0.001) in children and 1.92 (p<0.001) in adults. O/E ratios showed a significant, increasing trend with increasing UA quartiles in both children and adults for 3- and 4-variable clusters with p-values for trend <0.001, except for BMI-MAP-TG/HDLC and MAP-TG/HDLC-HOMA clusters in children and MAP-TG/HDLC-HOMA cluster in adults. ICCs of 3 and 4 components increased with increasing UA quartiles in children and adults.

Conclusions: These results indicate that UA may play a role in the development of MetS in both pediatric and adult populations alike, which may aid in the identification and treatment of high risk individuals for MetS and related clinical disorders in early life.

语种英语
所属项目编号5R01ES021724 ; 2R01AG016592 ; 13SDG14650068
资助者National Institute of Environmental Health Science ; National Institute on Aging ; American Heart Association ; National Institute of Environmental Health Science ; National Institute on Aging ; American Heart Association
WOS记录号WOS:000343943500001
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50373
专题北京大学公共卫生学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
2.Tulane Univ, Dept Epidemiol, New Orleans, LA 70118 USA
推荐引用方式
GB/T 7714
Sun, Dianjianyi,Li, Shengxu,Zhang, Xiaotao,et al. Uric Acid Is Associated with Metabolic Syndrome in Children and Adults in a Community: The Bogalusa Heart Study[J]. PLOS ONE,2014,9(10).
APA Sun, Dianjianyi.,Li, Shengxu.,Zhang, Xiaotao.,Fernandez, Camilo.,Chen, Wei.,...&Berenson, Gerald S..(2014).Uric Acid Is Associated with Metabolic Syndrome in Children and Adults in a Community: The Bogalusa Heart Study.PLOS ONE,9(10).
MLA Sun, Dianjianyi,et al."Uric Acid Is Associated with Metabolic Syndrome in Children and Adults in a Community: The Bogalusa Heart Study".PLOS ONE 9.10(2014).
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