北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Serum proteomic features for detection of endometrial cancer
作者: Zhu, LR1; Zhang, WY1; Yu, L1; Zheng, YH1; Zhang, JZ1; Liao, QP1
关键词: biomarkers ; endometrial cancer ; mass spectrometry ; proteomics
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
发表日期: 2006-05-01
卷: 16, 期:3, 页:1374-1378
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: SELDI-TOF-MS ; PROTEIN EXPRESSION ; IDENTIFICATION ; CARCINOMA
英文摘要:

To find new potential biomarkers for detection of endometrial cancer (EC), 70 serum samples including 40 from EC patients and 30 from normal healthy females were detected by surface-enhanced laser desorption-ionization time-of-flight mass spectrometry (SELDI-TOF-MS) using WCX2 (weak cation exchange) protein chip. Mass spectra were then assessed with three powerful data-mining tools: a tree classifier, Biomarker Wizard software, and Biomarker Patterns System. The diagnostic pattern combined with 13 potential biomarkers could differentiate EC patients from healthy persons, with a specificity of 100%, sensitivity of 92.5%, and total coincidence of 95.7%. The combination of surface-enhanced laser desorption-ionization with bioinformatics tools could help find new biomarkers and establish with high sensitivity and specificity for the detection of EC.

语种: 英语
WOS记录号: WOS:000238255300065
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50376
Appears in Collections:北京大学第一临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing, Peoples R China
2.306 Hosp PLA, Dept Pathol, Beijing, Peoples R China

Recommended Citation:
Zhu, LR,Zhang, WY,Yu, L,et al. Serum proteomic features for detection of endometrial cancer[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2006,16(3):1374-1378.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhu, LR]'s Articles
[Zhang, WY]'s Articles
[Yu, L]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhu, LR]‘s Articles
[Zhang, WY]‘s Articles
[Yu, L]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace