IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Serum proteomic features for detection of endometrial cancer
Zhu, LR1; Zhang, WY1; Yu, L1; Zheng, YH1; Zhang, JZ1; Liao, QP1
关键词Biomarkers Endometrial Cancer Mass Spectrometry Proteomics
刊名INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
2006-05-01
16期:3页:1374-1378
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Obstetrics & Gynecology
研究领域[WOS]Oncology ; Obstetrics & Gynecology
关键词[WOS]SELDI-TOF-MS ; PROTEIN EXPRESSION ; IDENTIFICATION ; CARCINOMA
英文摘要

To find new potential biomarkers for detection of endometrial cancer (EC), 70 serum samples including 40 from EC patients and 30 from normal healthy females were detected by surface-enhanced laser desorption-ionization time-of-flight mass spectrometry (SELDI-TOF-MS) using WCX2 (weak cation exchange) protein chip. Mass spectra were then assessed with three powerful data-mining tools: a tree classifier, Biomarker Wizard software, and Biomarker Patterns System. The diagnostic pattern combined with 13 potential biomarkers could differentiate EC patients from healthy persons, with a specificity of 100%, sensitivity of 92.5%, and total coincidence of 95.7%. The combination of surface-enhanced laser desorption-ionization with bioinformatics tools could help find new biomarkers and establish with high sensitivity and specificity for the detection of EC.

语种英语
WOS记录号WOS:000238255300065
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50376
专题北京大学第一临床医学院
作者单位1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing, Peoples R China
2.306 Hosp PLA, Dept Pathol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhu, LR,Zhang, WY,Yu, L,et al. Serum proteomic features for detection of endometrial cancer[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2006,16(3):1374-1378.
APA Zhu, LR,Zhang, WY,Yu, L,Zheng, YH,Zhang, JZ,&Liao, QP.(2006).Serum proteomic features for detection of endometrial cancer.INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,16(3),1374-1378.
MLA Zhu, LR,et al."Serum proteomic features for detection of endometrial cancer".INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 16.3(2006):1374-1378.
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