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学科主题: 临床医学
题名:
Serum proteomic features for detection of endometrial cancer
作者: Zhu, LR1; Zhang, WY1; Yu, L1; Zheng, YH1; Zhang, JZ1; Liao, QP1
关键词: biomarkers ; endometrial cancer ; mass spectrometry ; proteomics
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
发表日期: 2006-05-01
卷: 16, 期:3, 页:1374-1378
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: SELDI-TOF-MS ; PROTEIN EXPRESSION ; IDENTIFICATION ; CARCINOMA
英文摘要:

To find new potential biomarkers for detection of endometrial cancer (EC), 70 serum samples including 40 from EC patients and 30 from normal healthy females were detected by surface-enhanced laser desorption-ionization time-of-flight mass spectrometry (SELDI-TOF-MS) using WCX2 (weak cation exchange) protein chip. Mass spectra were then assessed with three powerful data-mining tools: a tree classifier, Biomarker Wizard software, and Biomarker Patterns System. The diagnostic pattern combined with 13 potential biomarkers could differentiate EC patients from healthy persons, with a specificity of 100%, sensitivity of 92.5%, and total coincidence of 95.7%. The combination of surface-enhanced laser desorption-ionization with bioinformatics tools could help find new biomarkers and establish with high sensitivity and specificity for the detection of EC.

语种: 英语
WOS记录号: WOS:000238255300065
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50376
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing, Peoples R China
2.306 Hosp PLA, Dept Pathol, Beijing, Peoples R China

Recommended Citation:
Zhu, LR,Zhang, WY,Yu, L,et al. Serum proteomic features for detection of endometrial cancer[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2006,16(3):1374-1378.
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