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学科主题: 临床医学
题名:
Reference intervals for serum creatinine with enzymatic assay and evaluation of four equations to estimate glomerular filtration rate in a healthy Chinese adult population
作者: Wang, XueJing1; Xu, GuoBin1; Li, HaiXia1; Liu, Yan1; Wang, Fang2
关键词: Creatinine ; Standardization ; Chinese ; Reference intervals ; Glomerular filtration rate
刊名: CLINICA CHIMICA ACTA
发表日期: 2011-09-18
DOI: 10.1016/j.cca.2011.05.033
卷: 412, 期:19-20, 页:1793-1797
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; 6 ASIAN CITIES ; CLASSIFICATION ; VALUES ; COMMON
英文摘要:

Background: With the wide usage of enzymatic assays to determine serum creatinine (Scr) in China, reference interval (RI) needs to be established. At the same time, the performance of Scr based equations to calculate estimated glomerular filtration rate (eGFR) in healthy Chinese adults has not been extensively investigated.

Methods: This study has strictly followed the International Federation of Clinical Chemistry (IFCC) recommendations and the Clinical Laboratory Standards Institute (CLSI) C28-A2 document. A total number of 778 healthy Chinese adults (male 433, female 345) were enrolled in this study.

Results: By nonparametric method, RIs for males were: <60 years, 58-93 mu mol/l and >60 years, 54-109 mu mol/l; RIs for females were: <60 years, 42-69 mu mol/l and >60 years, 43-83 mu mol/l. Modification of Diet in Renal Disease (MDRD) equation and MDRD for Japanese made the percentage of eGFR >90 ml/min/1.73 m(2) 31.7% and 4.9%; percentage of eGFR 60-89 ml/min/1.73 m(2) 65.2% and 64.0%, respectively. Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and CKD-EPI for Asian made the percentage of eGFR >90 ml/min/1.73 m(2) 89.2% and 94.0%; percentage of eGFR 60-89 ml/min/1.73 m(2) 10.3% and 5.7%, respectively.

Conclusion: Scr RIs of healthy Chinese adults were found to be lower than those of Caucasians. Two MDRD equations underestimated GFR, while two CKD-EPI equations seemed to estimate a reasonable distribution of eGFR in healthy Chinese adult populations. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2006AA020909
项目资助者: Ministry of Science and Technology of China
WOS记录号: WOS:000294396500014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50385
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Wang, XueJing,Xu, GuoBin,Li, HaiXia,et al. Reference intervals for serum creatinine with enzymatic assay and evaluation of four equations to estimate glomerular filtration rate in a healthy Chinese adult population[J]. CLINICA CHIMICA ACTA,2011,412(19-20):1793-1797.
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