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学科主题临床医学
Reference intervals for serum creatinine with enzymatic assay and evaluation of four equations to estimate glomerular filtration rate in a healthy Chinese adult population
Wang, XueJing1; Xu, GuoBin1; Li, HaiXia1; Liu, Yan1; Wang, Fang2
关键词Creatinine Standardization Chinese Reference Intervals Glomerular Filtration Rate
刊名CLINICA CHIMICA ACTA
2011-09-18
DOI10.1016/j.cca.2011.05.033
412期:19-20页:1793-1797
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]CHRONIC KIDNEY-DISEASE ; 6 ASIAN CITIES ; CLASSIFICATION ; VALUES ; COMMON
英文摘要

Background: With the wide usage of enzymatic assays to determine serum creatinine (Scr) in China, reference interval (RI) needs to be established. At the same time, the performance of Scr based equations to calculate estimated glomerular filtration rate (eGFR) in healthy Chinese adults has not been extensively investigated.

Methods: This study has strictly followed the International Federation of Clinical Chemistry (IFCC) recommendations and the Clinical Laboratory Standards Institute (CLSI) C28-A2 document. A total number of 778 healthy Chinese adults (male 433, female 345) were enrolled in this study.

Results: By nonparametric method, RIs for males were: <60 years, 58-93 mu mol/l and >60 years, 54-109 mu mol/l; RIs for females were: <60 years, 42-69 mu mol/l and >60 years, 43-83 mu mol/l. Modification of Diet in Renal Disease (MDRD) equation and MDRD for Japanese made the percentage of eGFR >90 ml/min/1.73 m(2) 31.7% and 4.9%; percentage of eGFR 60-89 ml/min/1.73 m(2) 65.2% and 64.0%, respectively. Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and CKD-EPI for Asian made the percentage of eGFR >90 ml/min/1.73 m(2) 89.2% and 94.0%; percentage of eGFR 60-89 ml/min/1.73 m(2) 10.3% and 5.7%, respectively.

Conclusion: Scr RIs of healthy Chinese adults were found to be lower than those of Caucasians. Two MDRD equations underestimated GFR, while two CKD-EPI equations seemed to estimate a reasonable distribution of eGFR in healthy Chinese adult populations. (C) 2011 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000294396500014
项目编号2006AA020909
资助机构Ministry of Science and Technology of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50385
专题北京大学第一临床医学院
北京大学第一临床医学院_检验科
作者单位1.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Nephrol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Wang, XueJing,Xu, GuoBin,Li, HaiXia,et al. Reference intervals for serum creatinine with enzymatic assay and evaluation of four equations to estimate glomerular filtration rate in a healthy Chinese adult population[J]. CLINICA CHIMICA ACTA,2011,412(19-20):1793-1797.
APA Wang, XueJing,Xu, GuoBin,Li, HaiXia,Liu, Yan,&Wang, Fang.(2011).Reference intervals for serum creatinine with enzymatic assay and evaluation of four equations to estimate glomerular filtration rate in a healthy Chinese adult population.CLINICA CHIMICA ACTA,412(19-20),1793-1797.
MLA Wang, XueJing,et al."Reference intervals for serum creatinine with enzymatic assay and evaluation of four equations to estimate glomerular filtration rate in a healthy Chinese adult population".CLINICA CHIMICA ACTA 412.19-20(2011):1793-1797.
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