北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 期刊论文
学科主题: 临床医学
题名:
Combination therapy of radiofrequency ablation and transarterial chemoembolization in recurrent hepatocellular carcinoma after hepatectomy compared with single treatment
作者: Yang, Wei1; Chen, Min Hua1; Wang, Mao Qiang2; Cui, Ming3; Gao, Wen1; Wu, Wei1; Wu, Jin Yu1; Dai, Ying1; Yan, Kun1
关键词: hepatocellular carcinoma ; radiofrequency ablation ; recurrence ; transarterial chemoembolization ; ultrasonography
刊名: HEPATOLOGY RESEARCH
发表日期: 2009-03-01
DOI: 10.1111/j.1872-034X.2008.00451.x
卷: 39, 期:3, 页:231-240
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: INTRAHEPATIC RECURRENCE ; CURATIVE RESECTION ; SURGICAL RESECTION ; TUMOR RECURRENCE ; CONTROLLED-TRIAL ; RISK-FACTORS ; MANAGEMENT ; LIVER ; EMBOLIZATION ; PROGNOSIS
英文摘要:

To assess the efficacy and safety of radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) in recurrent hepatocellular carcinoma (HCC) after hepatectomy and to compare its outcome with a single modality.

We retrospectively studied 103 patients with recurrent HCCs after hepatectomy who were excluded from repeat hepatectomy. Of them, 81 patients were male and 22 were female (mean age 55.8 +/- 10.7 years; range, 30-80 years). According to treatment modality, these patients were divided into three groups: RFA was used as the sole first-line anticancer treatment in 37 patients (RFA group); TACE was used as the sole first-line anticancer treatment in 35 patients (TACE group). RFA followed by TACE was performed in 31 patients (combination group). There was no significant difference in clinical material between the three groups. Indices including treatment success rate, intrahepatic recurrence rate and survival were obtained for analysis and comparison.

The treatment success rate of the combination group was significantly higher than that of the TACE group (93.5 vs. 68.6%, P = 0.011). The intrahepatic recurrence rate of the combination group was significantly lower than that of the TACE group (20.7 vs 57.1%, P = 0.002) and the RFA group (20.7 vs 43.2%, P = 0.036). The overall 1-, 3- and 5-year survival rates were 73.9, 51.1 and 28.0% respectively in the RFA group; 65.8, 38.9 and 19.5% respectively in the TACE group; and 88.5, 64.6 and 44.3% respectively in the combination group. There was a significant difference in survival between the combination group and the TACE group (P = 0.028).

RFA combined with TACE was more effective in treating recurrent HCC after hepatectomy compared to single RFA or TACE treatment. This combination therapy can thus be a valuable choice of treatment for recurrent HCC.

语种: 英语
所属项目编号: Z0005190040431
项目资助者: BMSTC (Beijing Medical Science Technology Commission)
WOS记录号: WOS:000263520700003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50386
Appears in Collections:北京大学临床肿瘤学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Ultrasound Dept, Beijing 100036, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Intervent Dept, Beijing, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Hepat Biliary & Pancreat Surg Dept, Beijing 100036, Peoples R China

Recommended Citation:
Yang, Wei,Chen, Min Hua,Wang, Mao Qiang,et al. Combination therapy of radiofrequency ablation and transarterial chemoembolization in recurrent hepatocellular carcinoma after hepatectomy compared with single treatment[J]. HEPATOLOGY RESEARCH,2009,39(3):231-240.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Wei]'s Articles
[Chen, Min Hua]'s Articles
[Wang, Mao Qiang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Wei]‘s Articles
[Chen, Min Hua]‘s Articles
[Wang, Mao Qiang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace