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学科主题临床医学
Combination therapy of radiofrequency ablation and transarterial chemoembolization in recurrent hepatocellular carcinoma after hepatectomy compared with single treatment
Yang, Wei1; Chen, Min Hua1; Wang, Mao Qiang2; Cui, Ming3; Gao, Wen1; Wu, Wei1; Wu, Jin Yu1; Dai, Ying1; Yan, Kun1
关键词Hepatocellular Carcinoma Radiofrequency Ablation Recurrence Transarterial Chemoembolization Ultrasonography
刊名HEPATOLOGY RESEARCH
2009-03-01
DOI10.1111/j.1872-034X.2008.00451.x
39期:3页:231-240
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]INTRAHEPATIC RECURRENCE ; CURATIVE RESECTION ; SURGICAL RESECTION ; TUMOR RECURRENCE ; CONTROLLED-TRIAL ; RISK-FACTORS ; MANAGEMENT ; LIVER ; EMBOLIZATION ; PROGNOSIS
英文摘要

To assess the efficacy and safety of radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) in recurrent hepatocellular carcinoma (HCC) after hepatectomy and to compare its outcome with a single modality.

We retrospectively studied 103 patients with recurrent HCCs after hepatectomy who were excluded from repeat hepatectomy. Of them, 81 patients were male and 22 were female (mean age 55.8 +/- 10.7 years; range, 30-80 years). According to treatment modality, these patients were divided into three groups: RFA was used as the sole first-line anticancer treatment in 37 patients (RFA group); TACE was used as the sole first-line anticancer treatment in 35 patients (TACE group). RFA followed by TACE was performed in 31 patients (combination group). There was no significant difference in clinical material between the three groups. Indices including treatment success rate, intrahepatic recurrence rate and survival were obtained for analysis and comparison.

The treatment success rate of the combination group was significantly higher than that of the TACE group (93.5 vs. 68.6%, P = 0.011). The intrahepatic recurrence rate of the combination group was significantly lower than that of the TACE group (20.7 vs 57.1%, P = 0.002) and the RFA group (20.7 vs 43.2%, P = 0.036). The overall 1-, 3- and 5-year survival rates were 73.9, 51.1 and 28.0% respectively in the RFA group; 65.8, 38.9 and 19.5% respectively in the TACE group; and 88.5, 64.6 and 44.3% respectively in the combination group. There was a significant difference in survival between the combination group and the TACE group (P = 0.028).

RFA combined with TACE was more effective in treating recurrent HCC after hepatectomy compared to single RFA or TACE treatment. This combination therapy can thus be a valuable choice of treatment for recurrent HCC.

语种英语
WOS记录号WOS:000263520700003
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50386
专题北京大学临床肿瘤学院
北京大学第三临床医学院_心血管内科
北京大学临床肿瘤学院_超声科
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Ultrasound Dept, Beijing 100036, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Intervent Dept, Beijing, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Hepat Biliary & Pancreat Surg Dept, Beijing 100036, Peoples R China
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Yang, Wei,Chen, Min Hua,Wang, Mao Qiang,et al. Combination therapy of radiofrequency ablation and transarterial chemoembolization in recurrent hepatocellular carcinoma after hepatectomy compared with single treatment[J]. HEPATOLOGY RESEARCH,2009,39(3):231-240.
APA Yang, Wei.,Chen, Min Hua.,Wang, Mao Qiang.,Cui, Ming.,Gao, Wen.,...&Yan, Kun.(2009).Combination therapy of radiofrequency ablation and transarterial chemoembolization in recurrent hepatocellular carcinoma after hepatectomy compared with single treatment.HEPATOLOGY RESEARCH,39(3),231-240.
MLA Yang, Wei,et al."Combination therapy of radiofrequency ablation and transarterial chemoembolization in recurrent hepatocellular carcinoma after hepatectomy compared with single treatment".HEPATOLOGY RESEARCH 39.3(2009):231-240.
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