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Efficacy and Safety of Transdermal Fentanyl (TDF) in Treatment of Pain Caused by Interventional Embolization Therapy
Zhu Xu; Yang Ren-jie; Chen Hui
关键词Transdermal Fentanyl Interventional Embolization Therapy Pain Relief
刊名CHINESE JOURNAL OF CANCER RESEARCH
2008-12-01
DOI10.1007/s11670-008-0316-5
20期:4页:316-319
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CANCER-RELATED PAIN ; ORAL MORPHINE ; MANAGEMENT ; MULTICENTER
英文摘要

Objective: Interventional embolization therapy is well accepted in cancer treatment, but patient may suffer from a moderate-to-severe pain after therapy and its quality of life (QoL) is influenced, this study is to observe the efficacy and safety of transdermal fentanyl (TDF) in the management of pain caused by interventional embolization therapy. Methods: Morphine 10mg and TDF 25 mu g/h were immediately used in 52 patients who had moderate-to-severe pain complicated by interventional embolization therapy, the pain intensity was evaluated by visual analogue scale ( VAS). If VAS >= 4 at 12 h after treatment, the dosage of TDF added into 50 mu g/h. At Oh, 12h, 24h, 72h, 1 week, 2 weeks after TD, the vas and adverse events were observed respectively. Result: There was an obvious decrease in VAS at 12h after TDF treatment in the patients of which only 9 patients used 50ug/h dosage after partial splenic embolization (PSE) therapy. Most patients got satisfactory pain relief both the TDF 25 mu g/h and TDF 50 mu g/h group ( VAS 0-1). The adverse events were nausea, vomiting and dizzy, especially in the TDF 50 mu g/h group. No respiratory depression was observed and only one patient got retention of urine. Conclusion: TDF was effective and safe in the treatment of moderate-to-severe pain after interventional embolization therapy.

语种英语
WOS记录号WOS:000263257300014
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50387
专题北京大学临床肿瘤学院_介入治疗科
作者单位Peking Univ Sch Oncol, Beijing Canc Hosp & Inst, Dept Intervent Therapy, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Zhu Xu,Yang Ren-jie,Chen Hui. Efficacy and Safety of Transdermal Fentanyl (TDF) in Treatment of Pain Caused by Interventional Embolization Therapy[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(4):316-319.
APA Zhu Xu,Yang Ren-jie,&Chen Hui.(2008).Efficacy and Safety of Transdermal Fentanyl (TDF) in Treatment of Pain Caused by Interventional Embolization Therapy.CHINESE JOURNAL OF CANCER RESEARCH,20(4),316-319.
MLA Zhu Xu,et al."Efficacy and Safety of Transdermal Fentanyl (TDF) in Treatment of Pain Caused by Interventional Embolization Therapy".CHINESE JOURNAL OF CANCER RESEARCH 20.4(2008):316-319.
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