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Decreased 4-1BB expression on CD4+CD25(high) regulatory T cells in peripheral blood of patients with multiple sclerosis
Liu, G. -Z.1; Gomes, A. C.2; Fang, L. -B.3; Gao, X. -G.1; Hjelmstrom, P.4
关键词4-1bb cd4+cd25(High) Regulatory t Cell Gitr Multiple Sclerosis Regulatory t Cell
刊名CLINICAL AND EXPERIMENTAL IMMUNOLOGY
2008-10-01
DOI10.1111/j.1365-2249.2008.03730
154期:1页:22-29
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
资助者National Natural Science ; Swedish Research Council ; Swedish Association of Neurologically Disabled ; National Natural Science ; Swedish Research Council ; Swedish Association of Neurologically Disabled
研究领域[WOS]Immunology
关键词[WOS]INDUCED TNF RECEPTOR ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; RHEUMATOID-ARTHRITIS ; EX-VIVO ; INTERLEUKIN-7 RECEPTOR ; CD137 ILA/4-1BB ; DENDRITIC CELLS ; SOLUBLE CD137 ; NO EVIDENCE ; IN-VITRO
英文摘要

As a tumour necrosis factor receptor superfamily member, 4-1BB (CD137) is preferentially expressed in CD4+CD25+ regulatory T cells (Tregs) and has been suggested to play an important role in regulating the generation or function of Tregs. Recent studies of human Tregs have shown that blood CD4+CD25(high) T cells were much closer to Tregs in terms of their functionality. Furthermore, CD4+CD25(high) Tregs have been found to have a decreased effector function in patients with multiple sclerosis (MS). In this study, we examined the expression of 4-1BB and soluble 4-1BB (s4-1BB) protein levels in the peripheral blood of MS patients. Compared with healthy controls, MS patients had decreased 4-1BB expression in their CD4+C25(high) Tregs and increased plasma s4-1BB protein levels. Moreover, the plasma s4-1BB levels of MS patients were shown to be inversely correlated with the 4-1BB surface expression of CD4+CD25(high) Tregs. The down-regulated 4-1BB expression on CD4+CD25(high) Tregs of MS patients may be involved in the impaired immunoactivity of these Tregs. The elevated s4-1BB levels may, at least in part, function as a self-regulatory attempt to inhibit antigen-driven proliferation of Tregs or their immunosuppressive activity.

语种英语
所属项目编号NSF 30470843 ; 11220
资助者National Natural Science ; Swedish Research Council ; Swedish Association of Neurologically Disabled ; National Natural Science ; Swedish Research Council ; Swedish Association of Neurologically Disabled
WOS记录号WOS:000259086800004
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50388
专题北京大学第二临床医学院_神经内科
作者单位1.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China
2.Huddinge Univ Hosp, Dept Clin Neurosci, Div Neurol, Stockholm, Sweden
3.Capital Med Univ, Dept Neurol, Beijing Fuxing Hosp, Beijing, Peoples R China
4.Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
推荐引用方式
GB/T 7714
Liu, G. -Z.,Gomes, A. C.,Fang, L. -B.,et al. Decreased 4-1BB expression on CD4+CD25(high) regulatory T cells in peripheral blood of patients with multiple sclerosis[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY,2008,154(1):22-29.
APA Liu, G. -Z.,Gomes, A. C.,Fang, L. -B.,Gao, X. -G.,&Hjelmstrom, P..(2008).Decreased 4-1BB expression on CD4+CD25(high) regulatory T cells in peripheral blood of patients with multiple sclerosis.CLINICAL AND EXPERIMENTAL IMMUNOLOGY,154(1),22-29.
MLA Liu, G. -Z.,et al."Decreased 4-1BB expression on CD4+CD25(high) regulatory T cells in peripheral blood of patients with multiple sclerosis".CLINICAL AND EXPERIMENTAL IMMUNOLOGY 154.1(2008):22-29.
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