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学科主题: 临床医学
题名:
Decreased 4-1BB expression on CD4+CD25(high) regulatory T cells in peripheral blood of patients with multiple sclerosis
作者: Liu, G. -Z.1; Gomes, A. C.2; Fang, L. -B.3; Gao, X. -G.1; Hjelmstrom, P.4
关键词: 4-1BB ; CD4+CD25(high) regulatory T cell ; GITR ; multiple sclerosis ; regulatory T cell
刊名: CLINICAL AND EXPERIMENTAL IMMUNOLOGY
发表日期: 2008-10-01
DOI: 10.1111/j.1365-2249.2008.03730
卷: 154, 期:1, 页:22-29
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: INDUCED TNF RECEPTOR ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; RHEUMATOID-ARTHRITIS ; EX-VIVO ; INTERLEUKIN-7 RECEPTOR ; CD137 ILA/4-1BB ; DENDRITIC CELLS ; SOLUBLE CD137 ; NO EVIDENCE ; IN-VITRO
英文摘要:

As a tumour necrosis factor receptor superfamily member, 4-1BB (CD137) is preferentially expressed in CD4+CD25+ regulatory T cells (Tregs) and has been suggested to play an important role in regulating the generation or function of Tregs. Recent studies of human Tregs have shown that blood CD4+CD25(high) T cells were much closer to Tregs in terms of their functionality. Furthermore, CD4+CD25(high) Tregs have been found to have a decreased effector function in patients with multiple sclerosis (MS). In this study, we examined the expression of 4-1BB and soluble 4-1BB (s4-1BB) protein levels in the peripheral blood of MS patients. Compared with healthy controls, MS patients had decreased 4-1BB expression in their CD4+C25(high) Tregs and increased plasma s4-1BB protein levels. Moreover, the plasma s4-1BB levels of MS patients were shown to be inversely correlated with the 4-1BB surface expression of CD4+CD25(high) Tregs. The down-regulated 4-1BB expression on CD4+CD25(high) Tregs of MS patients may be involved in the impaired immunoactivity of these Tregs. The elevated s4-1BB levels may, at least in part, function as a self-regulatory attempt to inhibit antigen-driven proliferation of Tregs or their immunosuppressive activity.

语种: 英语
所属项目编号: NSF 30470843 ; 11220
项目资助者: National Natural Science ; Swedish Research Council ; Swedish Association of Neurologically Disabled
WOS记录号: WOS:000259086800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50388
Appears in Collections:北京大学第二临床医学院_神经内科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China
2.Huddinge Univ Hosp, Dept Clin Neurosci, Div Neurol, Stockholm, Sweden
3.Capital Med Univ, Dept Neurol, Beijing Fuxing Hosp, Beijing, Peoples R China
4.Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden

Recommended Citation:
Liu, G. -Z.,Gomes, A. C.,Fang, L. -B.,et al. Decreased 4-1BB expression on CD4+CD25(high) regulatory T cells in peripheral blood of patients with multiple sclerosis[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY,2008,154(1):22-29.
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