北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Polymorphism of methionine synthase gene in nuclear families of congenital heart disease
作者: Zhu, WL1; Cheng, J1; Dao, JJ1; Zhao, RB1; Yan, LY1; Li, SQ1; Li, Y1
关键词: methionine synthase ; gene polymorphism ; congenital heart disease ; nuclear family
刊名: BIOMEDICAL AND ENVIRONMENTAL SCIENCES
发表日期: 2004-03-01
卷: 17, 期:1, 页:57-64
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: TOTAL PLASMA HOMOCYSTEINE ; RISK ; REDUCTASE
英文摘要:

Objective To investigate the relation of methionine synthase (MS) gene variation with congenital heart disease (CHD) phenotype. Methods One hundred and ninety three CHD patients (94 males and 99 females) and their biological parents (nuclear families) in Liaoning Province were selected as the case group, and another 104 normal persons (60 males and 44 females) and their parents without family history of birth defects as the control group. For all subjects the polymorphism of MS gene A2756G locus was examined by PCR-RFLP method. Results In offspring of the control group the frequencies of MS genotype (+/-) and allele (+) were 10.7% and 5.3%, without existence of homozygote. The MS genotype distribution and allele frequencies of CHD patients and their mothers were not significantly different from the control (P > 0.05). The frequency of allele (+) in case fathers (5.0%) was apparently lower than that in the control (9.1%, P=0.060), and the odds ratio (OR) was 0.53 (95% Cl: 0.25-1.09). There was no difference in parents′ genotype combination between the two groups, and in genotype distribution among different types of CHD. Analysis of genetic transmission indicated that mutation allele (+) existed transmission disequilibrium in CHD nuclear families. The percentage of allele (+) transmitted from parents was lower than that allele (-) with OR 0.26 (95% Cl: 0.11-0.60). Conclusion MS gene variation in parents is associated with occurrence of CHD in offspring, and mutation allele (+) in parents may be related with the decrease of CHD risk in offspring.

语种: 英语
WOS记录号: WOS:000220598000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50389
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Beijing Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China
2.China Med Univ, Hosp 2, Liaoning 110001, Peoples R China

Recommended Citation:
Zhu, WL,Cheng, J,Dao, JJ,et al. Polymorphism of methionine synthase gene in nuclear families of congenital heart disease[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2004,17(1):57-64.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhu, WL]'s Articles
[Cheng, J]'s Articles
[Dao, JJ]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhu, WL]‘s Articles
[Cheng, J]‘s Articles
[Dao, JJ]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace