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学科主题: 临床医学
题名:
Prevalence of hyperhomocysteinaemia and its major determinants in rural Chinese hypertensive patients aged 45-75 years
作者: Wang, Yu1; Li, Xiaoying1; Qin, Xianhui2; Cai, Yefeng3; He, Mingli4; Sun, Liming5; Li, Jianping6; Zhang, Yan6; Tang, Genfu7; Wang, Binyan2; Sun, Ningling8; Xu, Xin9; Liu, Lisheng10; Xu, Xiping2; Huo, Yong6
关键词: Prevalence ; Hyperhomocysteinaemia ; Hypertension ; Determinants ; Chinese
刊名: BRITISH JOURNAL OF NUTRITION
发表日期: 2013-04-14
DOI: 10.1017/S0007114512003157
卷: 109, 期:7, 页:1284-1293
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: PLASMA HOMOCYSTEINE CONCENTRATIONS ; FOLIC-ACID SUPPLEMENTATION ; METHYLENETETRAHYDROFOLATE REDUCTASE ; HORDALAND HOMOCYSTEINE ; CARDIOVASCULAR-DISEASE ; GENERAL-POPULATION ; STROKE PREVENTION ; HEART-DISEASE ; LIFE-STYLE ; B-VITAMINS
英文摘要:

We aimed to investigate the prevalence of hyperhomocysteinaemia (total plasma homocysteine (tHcy) >= 10 mu mol/l) and its major determinants in rural Chinese hypertensive patients. A cross-sectional investigation was carried out in Lianyungang of Jiangsu province, China. This analysis included 13 946 hypertensive adults. The prevalence of hyperhomocysteinaemia was 51.6% (42.7% in women and 65.6% in men). The OR of hyperhomocysteinaemia were 1.52 (95% CI 1.39, 1.67) and 2.32 (95% CI 2.07, 2.61) for participants aged 55-65 and 65-75 v. 45-55 years; 1.27 (95% CI 1.18, 1.37) for participants with a BMI >= 25 v. <25 kg/m(2); 1.14 (95% CI 1.06, 1.23) for participants with v. without antihypertensive treatment; 1.09 (95% CI 1.00, 1.18) for residents inland v. coastal; 0.89 (95% CI 0.82, 0.97) and 0.83 (95% CI 0.74, 0.92) for participants with moderate and high v. low physical activity levels; 1.54 (95% CI 1.41, 1.68) and 2.47 (95% CI 2.17, 2.81) for participants with a glomerular filtration rate 60-90 and <60 v. >= 90 ml/min per 1.73 m(2); and 1.20 (95% CI 1.07, 1.35) and 3.81 (95% CI 3.33, 4.36) for participants with CT and TT v. CC genotype at methylenetetrahydrofolate reductase 677C. T polymorphism, respectively. Furthermore, higher tHcy concentrations were observed in smokers of both sexes (men: geometric mean 12.1 (interquartile range (IQR) 9.2-14.5) v. 11.9 (IQR 9.3-14.0) mu mol/l, P=0.005; women: geometric mean 10.3 (IQR 8.3-13.0) v. 9.6 (IQR 7.8-11.6) mu mol/l, P = 0.010), and only in males with hypertension grade 3 (v. grade 1 or controlled blood pressure) (geometric mean 12.1 (IQR 9.2-14.4) v. 11.7 (IQR 9.2-14.0), P = 0.016) and in male non-drinkers (yes v. no) (geometric mean 12.3 (IQR 9.4-14.8) v. 11.7 (IQR 9.1-13.9), P = 0.014). In conclusion, there was a high prevalence of hyperhomocysteinaemia in Chinese hypertensive adults, particularly in the inlanders, who may benefit greatly from tHcy-lowering strategies, such as folic acid supplementation and lifestyle change.

语种: 英语
所属项目编号: 2012zx09101-105 ; (2010)1744
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China ; Department of Development and Reform, Shenzhen ; Department of Science, Industry, Trade and Information Technology, Shenzhen
WOS记录号: WOS:000317236600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50390
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing, Peoples R China
2.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
3.Guangdong Tradit Chinese Med Hosp, Dept Neurol, Guangzhou, Guangdong, Peoples R China
4.First Peoples Hosp Lianyungang City, Dept Neurol, Lianyungang, Peoples R China
5.Second Hosp Lianyungang City, Dept Cardiol, Lianyungang, Peoples R China
6.Peking Univ First Hosp, Dept Cardiol, Beijing, Peoples R China
7.Anhui Med Univ, Sch Hlth Adm, Hefei, Peoples R China
8.Peoples Hosp Peking Univ, Dept Cardiol, Beijing, Peoples R China
9.Southern Med Univ, Inst Nephrol, Guangzhou, Guangdong, Peoples R China
10.Fu Wai Hosp, Div Hypertens, Beijing, Peoples R China

Recommended Citation:
Wang, Yu,Li, Xiaoying,Qin, Xianhui,et al. Prevalence of hyperhomocysteinaemia and its major determinants in rural Chinese hypertensive patients aged 45-75 years[J]. BRITISH JOURNAL OF NUTRITION,2013,109(7):1284-1293.
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