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Four new eudesmane-type sesquiterpenoid lactones from atractylenolide II by biotransformation of rat hepatic microsomes
Li, Ying1; Liu, Jing2; Yang, Xiu-Wei1
关键词Atractylodes Macrocephala Atractylenolide Ii Rat Hepatic Microsomes Biotransformation
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
2013-04-01
DOI10.1080/10286020.2013.764867
15期:4页:344-356
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]ATRACTYLODES-MACROCEPHALA KOIDZ ; IN-VITRO ; NEOCLERODANE DITERPENOIDS ; LIVER MICROSOMES ; NO PRODUCTION ; CHROMATOGRAPHY ; PURIFICATION ; MYRISLIGNAN ; PLASMA ; VIVO
英文摘要

The biotransformation of atractylenolide II, a major bioactive principle of the rhizomes of Atractylodes macrocephala Koidz., was investigated in vitro by incubation with rat hepatic microsomes pretreated with sodium phenobarbital. The biotransformation products were extracted and purified by chromatographic methods. Seven biotransformation products (BP1BP7) were obtained and their structures were elucidated by NMR and MS data analyses and by comparison with the previously reported values, including four new compounds, namely 4(R),15-epoxy-atractylenolide II (BP1), 4(R),15-epoxy-13-hydroxyatractylenolide II (BP5), 4(R),15-epoxy-1-hydroxyatractylenolide II (BP6), and 4(R),15-dihydroxyatractylenolide II (BP7). The biotransformation pathway of atractylenolide II by hepatic microsomes was deducted based on the structure resolution of the products.

语种英语
WOS记录号WOS:000318349700005
项目编号2011BAI07B08 ; 2015
资助机构National Key Technology R&amp ; D Program of China ; Program of Improving the Standard of Pharmacopoeia of the People&prime ; s Republic of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50393
专题北京大学药学院_天然药物学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Dept Nat Med, Sch Pharmaceut Sci,Hlth Sci Ctr, Beijing 100191, Peoples R China
2.China Natl Ctr Biotechnol Dev, Beijing 100039, Peoples R China
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GB/T 7714
Li, Ying,Liu, Jing,Yang, Xiu-Wei. Four new eudesmane-type sesquiterpenoid lactones from atractylenolide II by biotransformation of rat hepatic microsomes[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2013,15(4):344-356.
APA Li, Ying,Liu, Jing,&Yang, Xiu-Wei.(2013).Four new eudesmane-type sesquiterpenoid lactones from atractylenolide II by biotransformation of rat hepatic microsomes.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,15(4),344-356.
MLA Li, Ying,et al."Four new eudesmane-type sesquiterpenoid lactones from atractylenolide II by biotransformation of rat hepatic microsomes".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 15.4(2013):344-356.
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