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学科主题: 药学
题名:
Four new eudesmane-type sesquiterpenoid lactones from atractylenolide II by biotransformation of rat hepatic microsomes
作者: Li, Ying1; Liu, Jing2; Yang, Xiu-Wei1
关键词: Atractylodes macrocephala ; atractylenolide II ; rat hepatic microsomes ; biotransformation
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2013-04-01
DOI: 10.1080/10286020.2013.764867
卷: 15, 期:4, 页:344-356
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: ATRACTYLODES-MACROCEPHALA KOIDZ ; IN-VITRO ; NEOCLERODANE DITERPENOIDS ; LIVER MICROSOMES ; NO PRODUCTION ; CHROMATOGRAPHY ; PURIFICATION ; MYRISLIGNAN ; PLASMA ; VIVO
英文摘要:

The biotransformation of atractylenolide II, a major bioactive principle of the rhizomes of Atractylodes macrocephala Koidz., was investigated in vitro by incubation with rat hepatic microsomes pretreated with sodium phenobarbital. The biotransformation products were extracted and purified by chromatographic methods. Seven biotransformation products (BP1BP7) were obtained and their structures were elucidated by NMR and MS data analyses and by comparison with the previously reported values, including four new compounds, namely 4(R),15-epoxy-atractylenolide II (BP1), 4(R),15-epoxy-13-hydroxyatractylenolide II (BP5), 4(R),15-epoxy-1-hydroxyatractylenolide II (BP6), and 4(R),15-dihydroxyatractylenolide II (BP7). The biotransformation pathway of atractylenolide II by hepatic microsomes was deducted based on the structure resolution of the products.

语种: 英语
所属项目编号: 2011BAI07B08 ; 2015
项目资助者: National Key Technology R&amp ; D Program of China ; Program of Improving the Standard of Pharmacopoeia of the People&prime ; s Republic of China
WOS记录号: WOS:000318349700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50393
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Dept Nat Med, Sch Pharmaceut Sci,Hlth Sci Ctr, Beijing 100191, Peoples R China
2.China Natl Ctr Biotechnol Dev, Beijing 100039, Peoples R China

Recommended Citation:
Li, Ying,Liu, Jing,Yang, Xiu-Wei. Four new eudesmane-type sesquiterpenoid lactones from atractylenolide II by biotransformation of rat hepatic microsomes[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2013,15(4):344-356.
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