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A concise route for the preparation of nucleobase-simplified cADPR mimics by click chemistry
Li, Lingjun; Lin, Baichuan; Yang, Zhenjun; Zhang, Liangren; Zhang, Lihe
关键词Cadpr Mimics Click Chemistry Ca(2+) Signaling
刊名TETRAHEDRON LETTERS
2008-07-21
DOI10.1016/j.tetlet.2008.05.076
49期:29-30页:4491-4493
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]CYCLIC-ADP-RIBOSE ; ADENOSINE-DIPHOSPHORIBOSE CADPR ; CARBOCYCLIC-RIBOSE ; ANALOGS ; 2ND-MESSENGER ; DERIVATIVES ; NUCLEOTIDES ; DISCOVERY ; AGONIST ; MOIETY
英文摘要

Novel nucleobase-modified cADPR mimics were synthesized by the application of click chemistry. Cu(I)-Huisge cycloaddition (click reaction) was used to construct 4-amide-1,2,3-triazole nucleobase and connect two building blocks efficiently. A concise protection strategy was used for the synthesis of the corresponding cyclo-pyrophosphate, and the target compounds 6a and 6b were prepared within four steps. (c) 2008 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000257401300010
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50397
专题北京大学药学院
北京大学药学院_药物化学系
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Li, Lingjun,Lin, Baichuan,Yang, Zhenjun,et al. A concise route for the preparation of nucleobase-simplified cADPR mimics by click chemistry[J]. TETRAHEDRON LETTERS,2008,49(29-30):4491-4493.
APA Li, Lingjun,Lin, Baichuan,Yang, Zhenjun,Zhang, Liangren,&Zhang, Lihe.(2008).A concise route for the preparation of nucleobase-simplified cADPR mimics by click chemistry.TETRAHEDRON LETTERS,49(29-30),4491-4493.
MLA Li, Lingjun,et al."A concise route for the preparation of nucleobase-simplified cADPR mimics by click chemistry".TETRAHEDRON LETTERS 49.29-30(2008):4491-4493.
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