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学科主题: 临床医学
题名:
Chemotherapy-induced Alteration of SDF-1/CXCR4 Expression in Bone Marrow-derived Mesenchymal Stem Cells From Adolescents and Young Adults With Acute Lymphoblastic Leukemia
作者: Ge, Jian1; Hu, Yan1; Gui, Yu1; Hou, Ruiqin2; Yang, Mingzhen1; Zeng, Qingshu1; Xia, Ruixiang1
关键词: mesenchymal stem cells ; stromal cell-derived factor-1 ; migration ; chemotherapy
刊名: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
发表日期: 2014-11-01
卷: 36, 期:8, 页:617-623
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology ; Pediatrics
研究领域[WOS]: Oncology ; Hematology ; Pediatrics
关键词[WOS]: PROMOTING MIGRATION ; CXCR4 EXPRESSION ; CHEMOKINE ; RECEPTOR ; MICROENVIRONMENT ; TRANSPLANTATION ; ENGRAFTMENT ; CHEMOTAXIS ; REMAIN ; DAMAGE
英文摘要:

Bone marrow-derived mesenchymal stem cells (BMMSCs) in the marrow stroma provide a scaffold for hematopoiesis. Chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 have been shown to affect the engraftment of hematopoietic stem cells. However, little is known about SDF-1/CXCR4′s functions in regulating BM-MSCs in humans. As an initial step toward this issue, we have evaluated expression of SDF1/CXCR4 in the BM-MSCs from a cohort of adolescents and young adults with acute lymphoblastic leukemia (ALL). We found a decrease of the CXCR4 level and an increase of the SDF-1 level in these MSCs of ALL. Moreover, cell migration appeared to be impaired in the MSCs of ALL. These changes were reversed by chemotherapy. Taken together, alteration of SDF-1/CXCR4 expression could be potentially developed as biomarkers for monitoring the effectiveness of chemotherapy.

语种: 英语
所属项目编号: 81200371 ; 20123420120011 ; 1208085QH154
项目资助者: National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China ; Anhui Provincial Natural Science Foundation of China
WOS记录号: WOS:000344224500025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50403
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Anhui Med Univ, Affiliated Hosp 1, Dept Hematol, Hefei 230022, Anhui, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Transfus Med, Beijing 100871, Peoples R China

Recommended Citation:
Ge, Jian,Hu, Yan,Gui, Yu,et al. Chemotherapy-induced Alteration of SDF-1/CXCR4 Expression in Bone Marrow-derived Mesenchymal Stem Cells From Adolescents and Young Adults With Acute Lymphoblastic Leukemia[J]. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY,2014,36(8):617-623.
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