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Gadolinium induced apoptosis of human embryo liver L02 cell line by ROS-mediated AIF pathway
Ye Lihua2; Shi Zhe1; Liu Huixue1; Yang Xiaoda2; Wang Kui1
关键词Gadolinium Chloride Mitochondria Ros Rare Earths
刊名JOURNAL OF RARE EARTHS
2011-02-01
DOI10.1016/S1002-0721(10)60427-9
29期:2页:178-184
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Chemistry
关键词[WOS]MOTEXAFIN GADOLINIUM ; DEATH ; EXPRESSION ; MEMBRANE ; PERMEABILITY ; MITOCHONDRIA ; RELEASE ; SIGNALS ; RAT
英文摘要

Gd(3+) complexes have a variety of medical applications. In order to shed light on the mechanism of hepatotoxicity of Gd(3+) compounds, we investigated the effects of GdCl(3) on human embryo liver cell strand (L02 cells). The experimental results showed that long-time exposure to GdCl(3) resulted in L02 cell apoptosis. The incubation of L02 cells with GdCl(3) first induced increase in cellular reactive oxygen species (ROS) and decrease in mitochondrial inner membrane potential (Delta psi(m)). It later resulted in the activation of poly (ADP-ribose) polymerase (PARP) and the release of mitochondrial apoptosis-inducing factor (AIF). The activation of caspase 3, however, was not observed. Antioxidants could significantly reduce GdCl(3)-induced decrease of Delta psi(m), release of AIF, and cell apoptosis. Although GdCl(3) caused a significant increase in cell membrane permeability in L02, the change of cell membrane permeability was unlikely to be involved in GdCl(3)-induced cell apoptosis. Overall, our experimental results suggested that GdCl(3) induced apoptosis of human embryo liver L02 cell line by ROS-mediated AIF pathway.

语种英语
所属项目编号20637010 ; 20671008 ; 20971008
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000288424800018
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50406
Collection北京大学药学院_化学生物学系
作者单位1.Peking Univ Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
2.Peking Univ, State Key Labs Nat & Biomimet Drugs, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Ye Lihua,Shi Zhe,Liu Huixue,et al. Gadolinium induced apoptosis of human embryo liver L02 cell line by ROS-mediated AIF pathway[J]. JOURNAL OF RARE EARTHS,2011,29(2):178-184.
APA Ye Lihua,Shi Zhe,Liu Huixue,Yang Xiaoda,&Wang Kui.(2011).Gadolinium induced apoptosis of human embryo liver L02 cell line by ROS-mediated AIF pathway.JOURNAL OF RARE EARTHS,29(2),178-184.
MLA Ye Lihua,et al."Gadolinium induced apoptosis of human embryo liver L02 cell line by ROS-mediated AIF pathway".JOURNAL OF RARE EARTHS 29.2(2011):178-184.
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