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学科主题: 药学
题名:
Gadolinium induced apoptosis of human embryo liver L02 cell line by ROS-mediated AIF pathway
作者: Ye Lihua2; Shi Zhe1; Liu Huixue1; Yang Xiaoda2; Wang Kui1
关键词: gadolinium chloride ; mitochondria ; ROS ; rare earths
刊名: JOURNAL OF RARE EARTHS
发表日期: 2011-02-01
DOI: 10.1016/S1002-0721(10)60427-9
卷: 29, 期:2, 页:178-184
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied
研究领域[WOS]: Chemistry
关键词[WOS]: MOTEXAFIN GADOLINIUM ; DEATH ; EXPRESSION ; MEMBRANE ; PERMEABILITY ; MITOCHONDRIA ; RELEASE ; SIGNALS ; RAT
英文摘要:

Gd(3+) complexes have a variety of medical applications. In order to shed light on the mechanism of hepatotoxicity of Gd(3+) compounds, we investigated the effects of GdCl(3) on human embryo liver cell strand (L02 cells). The experimental results showed that long-time exposure to GdCl(3) resulted in L02 cell apoptosis. The incubation of L02 cells with GdCl(3) first induced increase in cellular reactive oxygen species (ROS) and decrease in mitochondrial inner membrane potential (Delta psi(m)). It later resulted in the activation of poly (ADP-ribose) polymerase (PARP) and the release of mitochondrial apoptosis-inducing factor (AIF). The activation of caspase 3, however, was not observed. Antioxidants could significantly reduce GdCl(3)-induced decrease of Delta psi(m), release of AIF, and cell apoptosis. Although GdCl(3) caused a significant increase in cell membrane permeability in L02, the change of cell membrane permeability was unlikely to be involved in GdCl(3)-induced cell apoptosis. Overall, our experimental results suggested that GdCl(3) induced apoptosis of human embryo liver L02 cell line by ROS-mediated AIF pathway.

语种: 英语
所属项目编号: 20637010 ; 20671008 ; 20971008
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000288424800018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50406
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
2.Peking Univ, State Key Labs Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Ye Lihua,Shi Zhe,Liu Huixue,et al. Gadolinium induced apoptosis of human embryo liver L02 cell line by ROS-mediated AIF pathway[J]. JOURNAL OF RARE EARTHS,2011,29(2):178-184.
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