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学科主题: 精神卫生
题名:
No Association of Catechol-O-Methyltransferase Polymorphisms with Schizophrenia in the Han Chinese Population
作者: Zhang, Fuquan1,2; Liu, Chenxing1,2; Chen, Yaguang1,2; Wang, Lifang1,2; Lu, Tianlan1,2; Yan, Hao1,2; Ruan, Yanyan1,2; Yue, Weihua1,2; Zhang, Dai1,2
刊名: GENETIC TESTING AND MOLECULAR BIOMARKERS
发表日期: 2012-09-01
DOI: 10.1089/gtmb.2012.0061
卷: 16, 期:9, 页:1138-1141
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]: COMT ; METAANALYSIS ; GENE
英文摘要:

Aims: Genetics play a major role in the etiology of schizophrenia (SZ). Catechol-O-methyltransferase (COMT) is one of the promising candidate genes for SZ. A nonsynonymous single-nucleotide polymorphism (SNP), rs4680, causing a Valine (Val) to Methionine (Met) substitution, has been widely studied in relation to psychiatric phenotypes, including SZ, but with conflicting results. We conducted a two-stage study to examine the association of COMT polymorphisms with SZ in the Han Chinese population. Results: Association analysis of nine SNPs in 768 patients and 1348 controls failed to detect any positive markers or haplotypes. Then, we tested rs4680 in a validation sample of 963 patients and 992 controls, and no significant association was observed, but the cases significantly deviated from Hardy-Weinberg equilibrium (p = 5.7e-4). There was no association of rs4680 with SZ in the combined sample (n = 4071, p = 0.110, odds ratio = 1.08). Conclusions: Our results do not support the association of COMT with SZ in the Han Chinese population.

语种: 英语
所属项目编号: 2009AA022702 ; 81000578 ; 81071087 ; 81071088 ; 2011CB707805 ; 2010DFB30820
项目资助者: National High-Tech Research and Development Program of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; International Science and Technology Cooperation Program of China
WOS记录号: WOS:000308749500026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50408
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China

Recommended Citation:
Zhang, Fuquan,Liu, Chenxing,Chen, Yaguang,et al. No Association of Catechol-O-Methyltransferase Polymorphisms with Schizophrenia in the Han Chinese Population[J]. GENETIC TESTING AND MOLECULAR BIOMARKERS,2012,16(9):1138-1141.
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