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学科主题临床医学
Normoalbuminaemia is associated with IgA nephropathy in primary glomerulopathy with nephrotic-range proteinuria in Chinese patients
Chen, Min1,2,3; Zhou, Fu-de1,2,3; Zhao, Ming-hui1,2,3; Wang, Hai-yan1,2,3
关键词Iga Nephropathy Nephrotic Normoalbuminaemia Primary Glomerulopathy
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2011-04-01
DOI10.1093/ndt/gfq553
26期:4页:1247-1252
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
资助者Peking University ; National Natural Science Fund ; Peking University ; National Natural Science Fund
研究领域[WOS]Transplantation ; Urology & Nephrology
关键词[WOS]FOCAL SEGMENTAL GLOMERULOSCLEROSIS ; IDIOPATHIC MEMBRANOUS NEPHROPATHY ; CHRONIC KIDNEY-DISEASE ; FOLLOW-UP ; HYPOALBUMINEMIA ; EPIDEMIC
英文摘要

Background. Massive proteinuria is often associated with hypoalbuminaemia in glomerulopathy. However, patients may have normal levels of serum albumin despite heavy proteinuria in many circumstances. This study analysed factors affecting serum levels of albumin in primary glomerulopathy patients with nephrotic-range proteinuria.

Methods. The renal histopathological data of 780 consecutive adult patients (age >= 18 years old) with primary glomerulopathy and nephrotic-range proteinuria, who received native renal biopsies in Peking University First Hospital from 1998 to 2007, were retrospectively analysed.

Results. Compared with patients with hypoalbuminaemia (serum albumin < 30 g/L), patients without hypoalbuminaemia were significantly younger (P < 0.001) and had significantly lower levels of proteinuria (P < 0.001). Patients without hypoalbuminaemia had a significantly higher proportion of IgA nephropathy (66.0% vs. 17.2%, P < 0.001). The independent predictors of hypoalbuminaemia in nephrotic-range proteinuria patients included age, gender, interval between onset of the disease and renal biopsy, proteinuria level, and pathological type of glomerulopathy. A serum level of albumin = 35 g/L could predict IgA nephropathy with a specificity of 95.8%, and specificity increased with age.

Conclusions. Among patients with primary glomerulopathy and nephrotic-range proteinuria, normoalbuminaemia is associated with IgA nephropathy.

语种英语
所属项目编号985-2-033-39 ; 30972733
资助者Peking University ; National Natural Science Fund ; Peking University ; National Natural Science Fund
WOS记录号WOS:000289309400021
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50412
Collection北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Chen, Min,Zhou, Fu-de,Zhao, Ming-hui,et al. Normoalbuminaemia is associated with IgA nephropathy in primary glomerulopathy with nephrotic-range proteinuria in Chinese patients[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2011,26(4):1247-1252.
APA Chen, Min,Zhou, Fu-de,Zhao, Ming-hui,&Wang, Hai-yan.(2011).Normoalbuminaemia is associated with IgA nephropathy in primary glomerulopathy with nephrotic-range proteinuria in Chinese patients.NEPHROLOGY DIALYSIS TRANSPLANTATION,26(4),1247-1252.
MLA Chen, Min,et al."Normoalbuminaemia is associated with IgA nephropathy in primary glomerulopathy with nephrotic-range proteinuria in Chinese patients".NEPHROLOGY DIALYSIS TRANSPLANTATION 26.4(2011):1247-1252.
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