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学科主题: 临床医学
题名:
Normoalbuminaemia is associated with IgA nephropathy in primary glomerulopathy with nephrotic-range proteinuria in Chinese patients
作者: Chen, Min1,2,3; Zhou, Fu-de1,2,3; Zhao, Ming-hui1,2,3; Wang, Hai-yan1,2,3
关键词: IgA nephropathy ; nephrotic ; normoalbuminaemia ; primary glomerulopathy
刊名: NEPHROLOGY DIALYSIS TRANSPLANTATION
发表日期: 2011-04-01
DOI: 10.1093/ndt/gfq553
卷: 26, 期:4, 页:1247-1252
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Transplantation ; Urology & Nephrology
研究领域[WOS]: Transplantation ; Urology & Nephrology
关键词[WOS]: FOCAL SEGMENTAL GLOMERULOSCLEROSIS ; IDIOPATHIC MEMBRANOUS NEPHROPATHY ; CHRONIC KIDNEY-DISEASE ; FOLLOW-UP ; HYPOALBUMINEMIA ; EPIDEMIC
英文摘要:

Background. Massive proteinuria is often associated with hypoalbuminaemia in glomerulopathy. However, patients may have normal levels of serum albumin despite heavy proteinuria in many circumstances. This study analysed factors affecting serum levels of albumin in primary glomerulopathy patients with nephrotic-range proteinuria.

Methods. The renal histopathological data of 780 consecutive adult patients (age >= 18 years old) with primary glomerulopathy and nephrotic-range proteinuria, who received native renal biopsies in Peking University First Hospital from 1998 to 2007, were retrospectively analysed.

Results. Compared with patients with hypoalbuminaemia (serum albumin < 30 g/L), patients without hypoalbuminaemia were significantly younger (P < 0.001) and had significantly lower levels of proteinuria (P < 0.001). Patients without hypoalbuminaemia had a significantly higher proportion of IgA nephropathy (66.0% vs. 17.2%, P < 0.001). The independent predictors of hypoalbuminaemia in nephrotic-range proteinuria patients included age, gender, interval between onset of the disease and renal biopsy, proteinuria level, and pathological type of glomerulopathy. A serum level of albumin = 35 g/L could predict IgA nephropathy with a specificity of 95.8%, and specificity increased with age.

Conclusions. Among patients with primary glomerulopathy and nephrotic-range proteinuria, normoalbuminaemia is associated with IgA nephropathy.

语种: 英语
所属项目编号: 985-2-033-39 ; 30972733
项目资助者: Peking University ; National Natural Science Fund
WOS记录号: WOS:000289309400021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50412
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China

Recommended Citation:
Chen, Min,Zhou, Fu-de,Zhao, Ming-hui,et al. Normoalbuminaemia is associated with IgA nephropathy in primary glomerulopathy with nephrotic-range proteinuria in Chinese patients[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2011,26(4):1247-1252.
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