学科主题临床医学
Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells
Yu, Weidong1,3; Sun, Xiaolin1,4; Tang, Hongxing1; Tao, Yunxia1; Dai, Zonghan1,2
关键词PI3KC2 gamma p185(Bcr-Abl) SDF1 alpha chemotaxis
刊名LEUKEMIA & LYMPHOMA
2010-06-01
DOI10.3109/10428191003754624
51期:6页:1098-1107
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]BCR-ABL ; HEMATOPOIETIC-CELLS ; SIGNALING PATHWAY ; IN-VITRO ; TRANSFORMATION ; MIGRATION ; DOMAIN ; LEUKEMOGENESIS ; FACTOR-1-ALPHA ; APOPTOSIS
英文摘要

The expression of p185(Bcr-Abl) in Ba/F3 cells inhibits the chemotactic response of these cells to SDF1 alpha. A mutant p185(Bcr-Abl) with deletion of amino acids from 176 to 426 (p185(Delta 176-426)) is deficient in suppressing SDF1 alpha-stimulated chemotaxis. Comparison of the gene expression profiles among parental Ba/F3 cells and cells transformed by p185(Bcr-Abl) and p185(Delta 176-426) reveals that class II phosphoinositide 3-kinase gamma (PI3KC2 gamma) expression is markedly down-regulated by p185(Bcr-Abl) but not p185(Delta 176-426). Furthermore, knockdown of PI3KC2 gamma expression in p185(Delta 176-426) cells is sufficient to suppress SDF1 alpha-stimulated chemotaxis and to promote infiltration of these cells into the liver. Together, these studies suggest that inhibition of PI3KC2 gamma expression may represent a mechanism by which Bcr-Abl suppresses SDF1 alpha-induced chemotaxis and induces abnormal homing of leukemic cells.

语种英语
WOS记录号WOS:000279485300021
项目编号R01 CA094921 ; K01 DK067191
资助机构National Cancer Institute ; When Everyone Survives Foundation ; National Institute of Diabetes and Digestive and Kidney Diseases
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50414
专题北京大学第二临床医学院_临床分子生物学研究所
作者单位1.Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Amarillo, TX 79106 USA
2.Texas Tech Univ, Hlth Sci Ctr, Stem Cell Transplant Program, Amarillo, TX 79106 USA
3.Peking Univ, Peoples Hosp, Inst Clin Mol Biol, Beijing 100871, Peoples R China
4.China Agr Univ, Coll Biol Sci, State Key Lab Agrobiotechnol, Beijing 100094, Peoples R China
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GB/T 7714
Yu, Weidong,Sun, Xiaolin,Tang, Hongxing,et al. Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells[J]. LEUKEMIA & LYMPHOMA,2010,51(6):1098-1107.
APA Yu, Weidong,Sun, Xiaolin,Tang, Hongxing,Tao, Yunxia,&Dai, Zonghan.(2010).Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells.LEUKEMIA & LYMPHOMA,51(6),1098-1107.
MLA Yu, Weidong,et al."Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells".LEUKEMIA & LYMPHOMA 51.6(2010):1098-1107.
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