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学科主题: 公共卫生
题名:
Subclinical atherosclerosis in northern and southern China: the Chinese paradox
作者: Huang, Jie2,3; Wu, Yang-Feng4,5; Liu, Xiao-Qing6; Ding, Ding7; Zhao, Lian-Cheng8,9; Lu, Bin8,9; Li, Xian8,9; Wong, Nathan D.10; Dustin, Laurie D.11; Azen, Stanley P.11; Detrano, Robert C.1
关键词: coronary calcium ; CT scanning ; atherosclerosis ; epidemiology ; China
刊名: JOURNAL OF GERIATRIC CARDIOLOGY
发表日期: 2011
DOI: 10.3724/SP.J.1263.2011.00072
卷: 8, 期:2, 页:72-77
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Geriatrics & Gerontology
研究领域[WOS]: Cardiovascular System & Cardiology ; Geriatrics & Gerontology
关键词[WOS]: CORONARY-ARTERY CALCIUM ; DISEASE RISK-FACTORS ; COMPUTED-TOMOGRAPHY ; CALCIFICATION ; EVENTS ; CT ; QUANTIFICATION ; POPULATIONS ; CARDIA
英文摘要:

Background The incidence of coronary heart disease (CHD) is higher in Northern than that in Southern China, however differences in traditional CHD risk factors do not fully explain this. No study has examined the differences in subclinical atherosclerosis that may help explain the differences in incidence. This study examined these differences in subclinical atherosclerosis using coronary computed tomography (CT) for calcification between the Northern and Southern China. Methods We selected a random sample of participants in a large multi-center ongoing epidemiologic study for coronary calcium scanning in one northern city (North) (Beijing, n = 49) and in two southern cities (South) (Shanghai, n = 50, and Guangzhou, n = 50). Participants from the three field centers (mean age 67 years) underwent coronary risk factor evaluation and cardiac CT scanning for coronary calcium measurement using the Multi-Ethnic Study of Atherosclerosis scanning protocol. Results Adjusted log-transformed coronary artery calcium score in North China (Beijing) was 3.1 +/- 0.4 and in South China (Shanghai and Guangzhou) was 2.2 +/- 0.3 (P = 0.04). Mean calcium score for the northern city of Beijing was three times higher than that of the southern city of Guangzhou (P = 0.01) and 2.5 times higher than for the southern city of Shanghai (P = 0.03). Conclusions The extent of subclinical atherosclerosis is significantly higher in the northern city of Beijing than that in the two southern cities of Guangzhou and Shanghai, even after adjusting for standard cardiac risk factors. This finding suggests that standard risk factors do not fully explain north south differences in clinical CHD incidence.

语种: 英语
项目资助者: University of California, Irvine ; China California Heart Watch
WOS记录号: WOS:000296323500002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50422
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Fuwai Hosp, Beijing 100004, Peoples R China
2.Univ Calif Irvine, Div Cardiol, Irvine, CA 92697 USA
3.Univ So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90089 USA
4.Univ Calif Irvine, Sch Med, Dept Radiol, Irvine, CA 92697 USA
5.Fudan Univ, Clin Res Inst, Shanghai 200032, Peoples R China
6.Fudan Univ, Key Lab Hlth Technol Assessment, Minist Hlth, Sch Publ Hlth, Shanghai 200032, Peoples R China
7.Peking Univ, Sch Publ Hlth, Beijing 100083, Peoples R China
8.George Inst Global Hlth, Beijing 100083, Peoples R China
9.Guangdong Prov Peoples Hosp, Guangzhou 510030, Guangdong, Peoples R China
10.Fudan Univ, Hua Shan Hosp, Shanghai 200040, Peoples R China
11.Cardiovasc Inst, Beijing 100004, Peoples R China

Recommended Citation:
Huang, Jie,Wu, Yang-Feng,Liu, Xiao-Qing,et al. Subclinical atherosclerosis in northern and southern China: the Chinese paradox[J]. JOURNAL OF GERIATRIC CARDIOLOGY,2011,8(2):72-77.
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